Protein Overview: ATG11

General Information:
Name(s) found:	ATG11 / YPR049C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|805032\|emb\|CAA89169.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6325306\|ref\|NP_015374.1\| Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy); Atg11p [Saccharomyces cerevisiae [NCBI NR] gi\|61211724\|sp\|Q12527.1\|ATG11_YEAST RecName: Full=Autophagy-related protein 11; AltName: Full=Cytoplasm to vacuole targeting protein 9 [NCBI NR] gi\|1314120\|emb\|CAA94996.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S54073 probable membrane protein YPR049c - yeast (Saccharomyces cerevisiae) [NCBI NR] Autophagy-related protein 11 OS=Saccharomyces cerevisiae GN=ATG11 PE=1 SV=1 [Swiss-Prot] ATG11 Peripheral membrane protein required for stable binding of precursor API to its target membrane [mips] Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) [SGD] >Q12527 (Q12527) Hypothetical protein [4932.FASTACCERV.txt] Chr XVI from 664668-661132, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XVI from 661132-664668, reverse complement [yeastorf3.fasta] CVT9, Chr XVI from 661132-664668, reverse complement [yeast_orfs2] ATG11 SGDID:S0006253, Chr XVI from 664668-661132, reverse complement, Verified ORF [yeastflysequest.fasta] ATG11 SGDID:S0006253, Chr XVI from 664670-661134, reverse complement, Verified ORF [10112005cervSGD.fasta] Atg11p [Saccharomyces cerevisiae]gi\|805032\|emb\|CAA89169.1\| unknown [Saccharomyces cerevisiae]gi\|1314120\|emb\|CAA94996.1\| unknown [Saccharomyces cerevisiae]gi\|1084781\|pir\|\|S54073 probable membrane protein YPR049c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] (Q12527) Hypothetical protein YPR045C [cerv4932.FASTAC] ATG11 SGDID:S000006253, Chr XVI from 664670-661134, reverse complement, Verified ORF, "Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisoma [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ATG11 SGDID:S000006253, Chr XVI from 664670-661134, reverse complement, Verified ORF, "Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the pro-autophagosomal structure (PAS) for packaging [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] ATG11 SGDID:S000006253, Chr XVI from 664670-661134, reverse complement, Verified ORF, "Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging int [yeast-200209-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy); Atg11p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Autophagy-related protein 11 (Cytoplasm to vacuole targeting protein 9) [nr-271106-contam.fasta] ATG11 SGDID:S000006253, Chr XVI from 664670-661134, reverse complement, Verified ORF, "Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)" [yeast-bovrabprots.fasta] ATG11 SGDID:S000006253, Chr XVI from 664670-661134, reverse complement, Verified ORF, "Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy)" [yeast-contam_custom.fasta] [chemostatdb.fasta] Autophagy-related protein 11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG11 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ATG11 SGDID:S000006253, Chr XVI from 664673-661137, Genome Release 64-1-1, reverse complement, Verified ORF, "Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)" [yeast-030211-contam.fasta] ATG11 SGDID:S000006253, Chr XVI from 664673-661137, Genome Release 64-2-1, reverse complement, Verified ORF, "Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy" [20141208_orf_trans.fasta] YPR049C SGDID:S000006253, Chr XVI from 664673-661137, Genome Release 64-1-1, reverse complement, Verified ORF, "Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1178 amino acids
Gene Ontology:
Cellular Component:	extrinsic to membrane [IDA]
Biological Process:	peroxisome degradation [IMP] telomere maintenance [IMP] protein targeting to vacuole [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADADEYSTA PTQQEITPLQ TTATIINAIS GECITTNVDF FVSLDKFKQF IARKWKIPPD  60
   61 QLLILLPYGN KLKPSMFKEL LINRSFTLND FYVYDRRLFS LVSKPTPTNL LTSKDSNPMN 120
  121 SPNSNDLTET LEYLIKNSHI SQYQGSDTIM IKPMPSPLED ADVDLSRLNY HSVTSLLTTN 180
  181 LGWLSALEID VHYFKSLIPD IIAHIKRIFD GLTVCSQYLK LYCFDVESLY NSNVQFLNQL 240
  241 VDNGMTSKWE KCFNDTLSKL TALEGDSLQK FINIESLLEN EKSVKILNHS INGKLNKIKR 300
  301 EIDENASFRD IITVNIDRLR QMFTPNESKF ELEDQMAESF EVLVSEMRTR SRNVLDKEEE 360
  361 EFNSQEFLKS MNVMLEKDKK ESVKTLFTIS QALYSQIGEL IDLKKSLQKH AVAILGNIAF 420
  421 TQMEILGIKR LLLNECNKDL ELYKKYEVEF AQVEDLPLIY GLYLIEKYRR LSWFQQILSF 480
  481 ISNFNQDLEL FKQNELRTRN KWVKNFGSIA TVFCEDLLSS SDFKRLNEYH SHTSPPNEDE 540
  541 EDENENSIAN YRQDLVKVSQ AIDNYMTQIK ETDVSEPIID LLSKTLFETK RFHIIYSNFK 600
  601 NNNNNSSNGN SISPEGSIAL KSDDVVKGYK TRIKKLESLL HEFQYSDIGH WPQGVLNTHL 660
  661 KPFRGSATSI NKKKFLGASV LLEPANISEV NIDSVSQANN HQIQELESNV DDLLHQLQLL 720
  721 KEENNRKSMQ ISEMGKKISD LEVEKTAYRE TLTNLNQELA RLTNEEQSHR TEIFTLNASF 780
  781 KKQLNDIISQ DNEKIEKLTG DYDDVSKSRE RLQMDLDESN KKHEQEVNLL KADIERLGKQ 840
  841 IVTSEKSYAE TNSSSMEKGE KFETIPLAED PGRENQISAY TQTLQDRIFD IISTNIFILE 900
  901 NIGLLLTFDN NNNIQIRRVK GLKKGTAQSN ILDESTQMLD AHDNSLIKSP VFQKLKDEYE 960
  961 LIKSVANGSE KDTQQSIFLG NITQLYDNKL YEVAVIRRFK DIETLAKKLT KENKIKRTLL1020
 1021 ERFQREKVTL RNFQIGDLAL FLPTRENVNS VGSMSSSTSS LSSSFSSVDL STPPPLDAMS1080
 1081 IQSSPSVIHS NVINQASISG RDKNKLMRPW AAFTAFEEST RYFLKDEKGL TKGKEWFVGR1140
 1141 IVTLEHFVAD SPSNNPFRLP KGSVWFQVTA VVVSYQGV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ATG11 ATG17
View Details	Krogan NJ, et al. (2006)		ATG11 ATG17 ATG29 CIS1 THI11 YBR197C
View Details	Gavin AC, et al. (2006)		ATG11 ATG17 ATG29
View Details	Ho Y, et al. (2002)		AAC1 AAC3 ADE5,7 AHA1 ARC1 ARO1 ARP2 ATG11 ATG12 ATG17 CAR2 CPA2 CPR6 FET4 GCD11 GFA1 GUS1 IPP1 PPX1 PRB1 PTC7 REP1 REX2 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPT1 RPT3 SEC18 TCB1 TIF1, TIF2 TYR1 YHR020W YHR033W YNL208W
View Details	Qiu et al. (2008)		ATG11 ATG2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#34 Asynchronous SPB prep	Keck JM, et al. (2011)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PCF11	ATG11	2	Uetz P, et al. (2000)
View Screen	PCF11	ATG11	2	Unpublished Fields Lab Data
View Screen	PCF11	ATG11	2	Unpublished Fields Lab Data
View Screen	CAB3	ATG11	2	Hazbun TR, et al. (2003)
View Screen	CAB3	ATG11	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ATG11	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..376]	PSI-BLAST	24.0	Heavy meromyosin subfragment
2	View Details	[377..482]	deduced	N/A	Confident ab initio structure predictions are available.
3	View Details	[483..553]	PSI-BLAST	8.30103	Tropomyosin
4	View Details	[554..636]	PSI-BLAST	8.30103	Tropomyosin
5	View Details	[637..698]	PSI-BLAST	8.30103	Tropomyosin
6	View Details	[699..768]	PSI-BLAST	8.30103	Tropomyosin
7	View Details	[769..925]	PSI-BLAST	4.0	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
8	View Details	[926..1178]	MSA	27.829997	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	2.24002842608348	bayes_pls_golite062009
nucleic acid binding	1.29023721388505	bayes_pls_golite062009
transcription regulator activity	1.23558162468883	bayes_pls_golite062009
DNA binding	1.22770101477594	bayes_pls_golite062009
protein binding	1.03780839342631	bayes_pls_golite062009
transcription factor activity	0.65548647141585	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.16394692014973	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2