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Protein Overview: TOR2

General Information:
Name(s) found: TOR2 / YKL203C [SGD]
Description(s) found:
Found 13 descriptions.
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  • PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 2473 amino acids

    Gene Ontology:
    Cellular Component: TORC2 complex [IPILink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    extrinsic to internal side of plasma membrane [IDALink to PubMed article]
    vacuolar membrane [IDALink to PubMed article]
    TORC1 complex [IPILink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: cytoskeleton organization [IMPLink to PubMed article]
    regulation of cell growth [TASLink to PubMed article]
    signal transduction [TASLink to PubMed article]
    G1 phase of mitotic cell cycle [TASLink to PubMed article]
    ribosome biogenesis [IMPLink to PubMed article]
    Rho protein signal transduction [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    actin filament reorganization involved in cell cycle [TASLink to PubMed article]
    establishment or maintenance of actin cytoskeleton polarity [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]
    1-phosphatidylinositol-3-kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKYINKYTT PPNLLSLRQR AEGKHRTRKK LTHKSHSHDD EMSTTSNTDS NHNGPNDSGR  60
   61 VITGSAGHIG KISFVDSELD TTFSTLNLIF DKLKSDVPQE RASGANELST TLTSLAREVS 120
  121 AEQFQRFSNS LNNKIFELIH GFTSSEKIGG ILAVDTLISF YLSTEELPNQ TSRLANYLRV 180
  181 LIPSSDIEVM RLAANTLGRL TVPGGTLTSD FVEFEVRTCI DWLTLTADNN SSSSKLEYRR 240
  241 HAALLIIKAL ADNSPYLLYP YVNSILDNIW VPLRDAKLII RLDAAVALGK CLTIIQDRDP 300
  301 ALGKQWFQRL FQGCTHGLSL NTNDSVHATL LVFRELLSLK APYLRDKYDD IYKSTMKYKE 360
  361 YKFDVIRREV YAILPLLAAF DPAIFTKKYL DRIMVHYLRY LKNIDMNAAN NSDKPFILVS 420
  421 IGDIAFEVGS SISPYMTLIL DNIREGLRTK FKVRKQFEKD LFYCIGKLAC ALGPAFAKHL 480
  481 NKDLLNLMLN CPMSDHMQET LMILNEKIPS LESTVNSRIL NLLSISLSGE KFIQSNQYDF 540
  541 NNQFSIEKAR KSRNQSFMKK TGESNDDITD AQILIQCFKM LQLIHHQYSL TEFVRLITIS 600
  601 YIEHEDSSVR KLAALTSCDL FIKDDICKQT SVHALHSVSE VLSKLLMIAI TDPVAEIRLE 660
  661 ILQHLGSNFD PQLAQPDNLR LLFMALNDEI FGIQLEAIKI IGRLSSVNPA YVVPSLRKTL 720
  721 LELLTQLKFS NMPKKKEESA TLLCTLINSS DEVAKPYIDP ILDVILPKCQ DASSAVASTA 780
  781 LKVLGELSVV GGKEMTRYLK ELMPLIINTF QDQSNSFKRD AALTTLGQLA ASSGYVVGPL 840
  841 LDYPELLGIL INILKTENNP HIRRGTVRLI GILGALDPYK HREIEVTSNS KSSVEQNAPS 900
  901 IDIALLMQGV SPSNDEYYPT VVIHNLMKIL NDPSLSIHHT AAIQAIMHIF QNLGLRCVSF 960
  961 LDQIIPGIIL VMRSCPPSQL DFYFQQLGSL ISIVKQHIRP HVEKIYGVIR EFFPIIKLQI1020
 1021 TIISVIESIS KALEGEFKRF VPETLTFFLD ILENDQSNKR IVPIRILKSL VTFGPNLEDY1080
 1081 SHLIMPIVVR MTEYSAGSLK KISIITLGRL AKNINLSEMS SRIVQALVRI LNNGDRELTK1140
 1141 ATMNTLSLLL LQLGTDFVVF VPVINKALLR NRIQHSVYDQ LVNKLLNNEC LPTNIIFDKE1200
 1201 NEVPERKNYE DEMQVTKLPV NQNILKNAWY CSQQKTKEDW QEWIRRLSIQ LLKESPSACL1260
 1261 RSCSSLVSVY YPLARELFNA SFSSCWVELQ TSYQEDLIQA LCKALSSSEN PPEIYQMLLN1320
 1321 LVEFMEHDDK PLPIPIHTLG KYAQKCHAFA KALHYKEVEF LEEPKNSTIE ALISINNQLH1380
 1381 QTDSAIGILK HAQQHNELQL KETWYEKLQR WEDALAAYNE KEAAGEDSVE VMMGKLRSLY1440
 1441 ALGEWEELSK LASEKWGTAK PEVKKAMAPL AAAAWGLEQW DEIAQYTSVM KSQSPDKEFY1500
 1501 DAILCLHRNN FKKAEVHIFN ARDLLVTELS ALVNESYNRA YNVVVRAQII AELEEIIKYK1560
 1561 KLPQNSDKRL TMRETWNTRL LGCQKNIDVW QRILRVRSLV IKPKEDAQVR IKFANLCRKS1620
 1621 GRMALAKKVL NTLLEETDDP DHPNTAKASP PVVYAQLKYL WATGLQDEAL KQLINFTSRM1680
 1681 AHDLGLDPNN MIAQSVPQQS KRVPRHVEDY TKLLARCFLK QGEWRVCLQP KWRLSNPDSI1740
 1741 LGSYLLATHF DNTWYKAWHN WALANFEVIS MLTSVSKKKQ EGSDASSVTD INEFDNGMIG1800
 1801 VNTFDAKEVH YSSNLIHRHV IPAIKGFFHS ISLSESSSLQ DALRLLTLWF TFGGIPEATQ1860
 1861 AMHEGFNLIQ IGTWLEVLPQ LISRIHQPNQ IVSRSLLSLL SDLGKAHPQA LVYPLMVAIK1920
 1921 SESLSRQKAA LSIIEKMRIH SPVLVDQAEL VSHELIRMAV LWHEQWYEGL DDASRQFFGE1980
 1981 HNTEKMFAAL EPLYEMLKRG PETLREISFQ NSFGRDLNDA YEWLMNYKKS KDVSNLNQAW2040
 2041 DIYYNVFRKI GKQLPQLQTL ELQHVSPKLL SAHDLELAVP GTRASGGKPI VKISKFEPVF2100
 2101 SVISSKQRPR KFCIKGSDGK DYKYVLKGHE DIRQDSLVMQ LFGLVNTLLQ NDAECFRRHL2160
 2161 DIQQYPAIPL SPKSGLLGWV PNSDTFHVLI REHREAKKIP LNIEHWVMLQ MAPDYDNLTL2220
 2221 LQKVEVFTYA LNNTEGQDLY KVLWLKSRSS ETWLERRTTY TRSLAVMSMT GYILGLGDRH2280
 2281 PSNLMLDRIT GKVIHIDFGD CFEAAILREK FPEKVPFRLT RMLTYAMEVS GIEGSFRITC2340
 2341 ENVMKVLRDN KGSLMAILEA FAFDPLINWG FDLPTKKIEE ETGIQLPVMN ANELLSNGAI2400
 2401 TEEEVQRVEN EHKNAIRNAR AMLVLKRITD KLTGNDIRRF NDLDVPEQVD KLIQQATSVE2460
 2461 NLCQHYIGWC PFW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run MIA40 No Comments Hazbun TR, et al. (2003)
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A No confident structure predictions are available.
    2 View Details [76..409] ORFEUS 11.19 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    3 View Details [410..563] deduced N/A No confident structure predictions are available.
    4 View Details [564..1014] MSA 21.428996 View MSA. No confident structure predictions are available.
    5 View Details [1015..1094] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [1095..1230] MSA 2.195995 View MSA. Confident ab initio structure predictions are available.
    7 View Details [1231..1309] deduced N/A Confident ab initio structure predictions are available.
    8 View Details [1310..1601] MSA 13.097997 View MSA. No confident structure predictions are available.
    9 View Details [1602..1940] MSA 1.092973 View MSA. No confident structure predictions are available.
    10 View Details [1941..2083] PSI-BLAST 347.218487 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
    11 View Details [2084..2473] MSA 13.116964 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle