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Protein Overview: MET10

General Information:
Name(s) found: MET10 / YFR030W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1035 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    sulfite reductase complex (NADPH) [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    sulfate assimilation [TASLink to PubMed article]
    Molecular Function: sulfite reductase (NADPH) activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVEFATNPF GEAKNATSLP KYGTPVTAIS SVLFNNVDSI FAYKSFSQPD LLHQDLKKWS  60
   61 EKRGNESRGK PFFQELDIRS GAGLAPLGFS HGLKNTTAIV APGFSLPYFI NSLKTVSHDG 120
  121 KFLLNVGALN YDNATGSVTN DYVTALDAAS KLKYGVVTPI SANEVQSVAL LALAIATFSN 180
  181 NSGAINLFDG LNYSKTVLPL VESVPEASIL AKLSKVIAPD AAFDDVLDKF NELTGLRLHN 240
  241 FQYFGAQDAE TVFITYGSLE SELFNSAISG NNSKIGLINV RVPLPFNVAK FVTHVPSTTK 300
  301 QIVVIGQTLD GSSPSFLRSQ VSAALFYHGR TSISVSEYIY QPDFIWSPKA VKSIVSSFIP 360
  361 EFTYNADSSF GEGFIYWASD KSINIDVASK LVKALSLEDG KFVSLRTKFD NLANAGTFQA 420
  421 QFVTSKEQIP VSNIDSTKLS VVEDVSLLKH LDVAATVAEQ GSIALVSQKA VKDLDLNSVE 480
  481 SYVKNLGIPE SFLISIAKKN IKLFIIDGET TNDESKLSLF IQAVFWKLAF GLDVAECTNR 540
  541 IWKSIDSGAD ISAASISEFL TGAFKNFLSE VPLALYTKFS EINIEKKEDE EEPAALPIFV 600
  601 NETSFLPNNS TIEEIPLPET SEISDIAKKL SFKEAYEVEN KLRPDLPVKN FVVKVKENRR 660
  661 VTPADYDRYI FHIEFDISGT GMTYDIGEAL GIHARNNESL VKEFLTFYGL NESDVVLVPN 720
  721 KDNHHLLETR TVLQAFVENL DIFGKPPKRF YESLIPYASN EEEKKKLEDL VTPAGAVDLK 780
  781 RFQDVEYYTY ADIFELFPSV RPSLEELVTI IEPLKRREYS IASSQKVHPN EVHLLIVVVD 840
  841 WVDNKGRKRY GQASKYISDL AVGSELVVSV KPSVMKLPPS PKQPVIMSGL GTGLAPFKAI 900
  901 VEEKLWQKQQ GYEIGEVFLY LGSRHKREEY LYGELWEAYK DAGIITHIGA AFSRDQPQKI 960
  961 YIQDRIKENL DELKTAMIDN KGSFYLCGPT WPVPDITQAL QDILAKDAEE RGIKVDLDAA1020
 1021 IEELKEASRY ILEVY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1
    View Details Gavin AC, et al. (2006) MET10 RPA135
    View Details Ho Y, et al. (2002) ATG12 CDC28 CLU1 CRM1 FET3 GSY1 KAP122 KGD1 MET10 MET18 PFK1 RPN1 TCP1
    View Details Qiu et al. (2008) MET10 MET5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SDO1 No Comments Hazbun TR, et al. (2003)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run UTP25 No Comments Hazbun TR, et al. (2003)
    View Run SMC5 No Comments Hazbun TR, et al. (2003)
    View Run NSE3 No Comments Hazbun TR, et al. (2003)
    View Run YMR185W No Comments Hazbun TR, et al. (2003)
    View Run PGA1 No Comments Hazbun TR, et al. (2003)
    View Run GWT1 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DOT1 MET10 1 Unpublished Fields Lab Data
    View Screen UBC7 MET10 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MET10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..373] PSI-BLAST 231.9897 Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
    2 View Details [374..643] PSI-BLAST 231.9897 Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
    3 View Details [644..694]
    [816..839]
    [852..873]    		 PSI-BLAST 618.54902 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
    4 View Details [695..815]
    [840..851]
    [874..1035]    		 PSI-BLAST 618.54902 NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.53979678006253 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  1.31432587516415 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  1.05771099058484 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  0.91689889002022 bayes_pls_golite062009
  • catalytic activity
    		•  0.488483980994331 bayes_pls_golite062009
  • binding
    		•  0.284953915352797 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.240775137189639 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  0.201869061877972 bayes_pls_golite062009
    2
    Term Confidence Notes
  • sulfite reductase (NADPH) activity
    		•  8.084406223553 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  4.30314846685644 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  4.06091555929351 bayes_pls_golite062009
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  1.198269073975 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.812246071526761 bayes_pls_golite062009
  • transferase activity
    		•  0.708491789248912 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.637241226597849 bayes_pls_golite062009
  • binding
    		•  0.568113451649995 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle