YRC Public Data Repository - Protein Structure Prediction

Protein:	MET10
Organism:	Saccharomyces cerevisiae
Length:	1035 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET10.

Description	E-value	Query Range	Subject Range
MET10 - Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide MET10_YEAST - Sulfite reductase [NADPH] flavoprotein component OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...	0.0	[1..1035]	[1..1035]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..1035]	[1..1035]
gi\|25284484 - pir\|\|B97208 pyruvate ferredoxin oxidoreductase CAC2499 [imported] - Clostridium acetobutylicum gi\|15025520, gi\|... - gi\|15895764\|ref\|NP_349113.1\| pyruvate ferredoxin oxidoreductase [Clostridium acetobutylicum ATCC 824...	0.0	[17..637]	[4..673]
gi\|4972241 - gi\|4972241\|emb\|CAB43935.1\| pyruvate ferredoxin oxidoreductase [Clostridium pasteurianum]	0.0	[16..637]	[2..674]
gi\|18145725, gi\|... - gi\|18311043\|ref\|NP_562977.1\| pyruvate-flavodoxin oxidoreductase [Clostridium perfringens str. 13], g...	0.0	[16..701]	[4..765]
NIFJ_ENTAG - Pyruvate-flavodoxin oxidoreductase OS=Enterobacter agglomerans GN=nifJ PE=3 SV=3	0.0	[15..637]	[2..674]

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Predicted Domain #1

Region A:
Residues: [1-373]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVEFATNPF GEAKNATSLP KYGTPVTAIS SVLFNNVDSI FAYKSFSQPD LLHQDLKKWS  60
   61 EKRGNESRGK PFFQELDIRS GAGLAPLGFS HGLKNTTAIV APGFSLPYFI NSLKTVSHDG 120
  121 KFLLNVGALN YDNATGSVTN DYVTALDAAS KLKYGVVTPI SANEVQSVAL LALAIATFSN 180
  181 NSGAINLFDG LNYSKTVLPL VESVPEASIL AKLSKVIAPD AAFDDVLDKF NELTGLRLHN 240
  241 FQYFGAQDAE TVFITYGSLE SELFNSAISG NNSKIGLINV RVPLPFNVAK FVTHVPSTTK 300
  301 QIVVIGQTLD GSSPSFLRSQ VSAALFYHGR TSISVSEYIY QPDFIWSPKA VKSIVSSFIP 360
  361 EFTYNADSSF GEG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	231.9897
Match:	1b0pA_
Description:	Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	2.53979678006253	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	1.31432587516415	bayes_pls_golite062009
pyruvate dehydrogenase activity	1.05771099058484	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	0.91689889002022	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009
binding	0.284953915352797	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.240775137189639	bayes_pls_golite062009
acetolactate synthase activity	0.201869061877972	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [374-643]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIYWASDKSI NIDVASKLVK ALSLEDGKFV SLRTKFDNLA NAGTFQAQFV TSKEQIPVSN  60
   61 IDSTKLSVVE DVSLLKHLDV AATVAEQGSI ALVSQKAVKD LDLNSVESYV KNLGIPESFL 120
  121 ISIAKKNIKL FIIDGETTND ESKLSLFIQA VFWKLAFGLD VAECTNRIWK SIDSGADISA 180
  181 ASISEFLTGA FKNFLSEVPL ALYTKFSEIN IEKKEDEEEP AALPIFVNET SFLPNNSTIE 240
  241 EIPLPETSEI SDIAKKLSFK EAYEVENKLR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	231.9897
Match:	1b0pA_
Description:	Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sulfite reductase (NADPH) activity	8.084406223553	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	4.30314846685644	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	4.06091555929351	bayes_pls_golite062009
catalytic activity	1.45374095556065	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.198269073975	bayes_pls_golite062009
oxidoreductase activity	0.812246071526761	bayes_pls_golite062009
transferase activity	0.708491789248912	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.637241226597849	bayes_pls_golite062009
binding	0.568113451649995	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [644-694]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDLPVKNFVV KVKENRRVTP ADYDRYIFHI EFDISGTGMT YDIGEALGIH A

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [816-839]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RREYSIASSQ KVHPNEVHLL IVVV

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [852-873]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QASKYISDLA VGSELVVSVK PS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	618.54902
Match:	1amoA_
Description:	NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [695-815]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNNESLVKEF LTFYGLNESD VVLVPNKDNH HLLETRTVLQ AFVENLDIFG KPPKRFYESL  60
   61 IPYASNEEEK KKLEDLVTPA GAVDLKRFQD VEYYTYADIF ELFPSVRPSL EELVTIIEPL 120
  121 K

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [840-851]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWVDNKGRKR YG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [874-1035]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMKLPPSPKQ PVIMSGLGTG LAPFKAIVEE KLWQKQQGYE IGEVFLYLGS RHKREEYLYG  60
   61 ELWEAYKDAG IITHIGAAFS RDQPQKIYIQ DRIKENLDEL KTAMIDNKGS FYLCGPTWPV 120
  121 PDITQALQDI LAKDAEERGI KVDLDAAIEE LKEASRYILE VY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	618.54902
Match:	1amoA_
Description:	NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: