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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • DMA2
  • cytoplasm
  • mitotic cell cycle spindle assembly checkpoint
  • establishment of mitotic spindle orientation
  • septin ring assembly
  • molecular_function
  • DUN1
  • nucleus
  • DNA damage checkpoint
  • cell cycle checkpoint
  • telomere maintenance
  • protein amino acid phosphorylation
  • protein kinase activity
  • FAR1
  • nucleus
  • cytoplasm
  • membrane
  • mating projection tip
  • cell cycle arrest
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • cyclin-dependent protein kinase inhibitor activity
  • GPD1
  • peroxisome
  • cytosol
  • NADH oxidation
  • intracellular accumulation of glycerol
  • glycerol-3-phosphate dehydrogenase (NAD+) activity
  • GPD2
  • mitochondrion
  • cytosol
  • glycerol metabolic process
  • NADH oxidation
  • glycerol-3-phosphate dehydrogenase (NAD+) activity
  • LSP1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • endocytosis
  • protein kinase inhibitor activity
  • MDM30
  • mitochondrion
  • mitochondrial fusion
  • mitochondrion organization
  • molecular_function
  • PDC6
  • cytoplasm
  • ethanol metabolic process
  • pyruvate decarboxylase activity
  • PIL1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • protein localization
  • endocytosis
  • protein kinase inhibitor activity
  • RAD1
  • nucleotide-excision repair factor 1 complex
  • nucleus
  • nucleotide-excision repair, DNA incision, 5'-to lesion
  • double-strand break repair via single-strand annealing, removal of nonhomologous ends
  • removal of nonhomologous ends
  • meiotic mismatch repair
  • mitotic recombination
  • DNA binding
  • single-stranded DNA specific endodeoxyribonuclease activity
  • SAW1
  • nucleus
  • biological_process
  • molecular_function
  • SEC6
  • cellular bud tip
  • exocyst
  • vesicle fusion
  • bipolar cellular bud site selection
  • vesicle docking during exocytosis
  • Golgi to plasma membrane transport
  • cytokinesis
  • protein binding
  • SEN1
  • nucleus
  • nuclear outer membrane
  • snRNA processing
  • tRNA processing
  • snoRNA processing
  • transcription termination
  • termination of RNA polymerase II transcription
  • DNA-dependent ATPase activity
  • RNA helicase activity
  • RNA-dependent ATPase activity
  • RNA polymerase II transcription termination factor activity
  • 5'-3' DNA helicase activity
  • STE20
  • incipient cellular bud site
  • mating projection tip
  • cellular bud site selection
  • regulation of exit from mitosis
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • protein amino acid phosphorylation
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • protein serine/threonine kinase activity
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eisosome 6.8716E-6 17 2 2 6292
    cell cortex part 2.0042E-3 17 96 3 6292
    cell cortex 2.8814E-3 17 109 3 6292
    mating projection tip 3.8798E-3 17 35 2 6292
    cell projection part 5.5522E-3 17 42 2 6292
    cell projection 7.4998E-3 17 49 2 6292
    mating projection 7.4998E-3 17 49 2 6292
    nucleotide-excision repair factor 1 complex 8.0849E-3 17 3 1 6292
    site of polarized growth 9.6524E-3 17 168 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular developmental process 5.5462E-5 17 276 6 6292
    developmental process 1.5292E-4 17 331 6 6292
    response to stimulus 4.1181E-4 17 766 8 6292
    cellular component morphogenesis 4.2226E-4 17 138 4 6292
    NADH oxidation 4.4637E-4 17 12 2 6292
    anatomical structure morphogenesis 4.5163E-4 17 257 5 6292
    anatomical structure development 4.765E-4 17 260 5 6292
    NADH metabolic process 7.0676E-4 17 15 2 6292
    establishment of cell polarity 1.3637E-3 17 84 3 6292
    response to stress 1.3717E-3 17 497 6 6292
    reproduction 1.3735E-3 17 328 5 6292
    establishment or maintenance of cell polarity 1.4112E-3 17 85 3 6292
    cellular membrane organization 1.6405E-3 17 198 4 6292
    membrane organization 1.6405E-3 17 198 4 6292
    cell cycle 1.826E-3 17 525 6 6292
    response to heat 1.8314E-3 17 24 2 6292
    NAD metabolic process 1.9875E-3 17 25 2 6292
    reproductive cellular process 2.074E-3 17 211 4 6292
    reproductive process 2.1103E-3 17 212 4 6292
    signal transduction 2.1843E-3 17 214 4 6292
    signal transmission 2.2987E-3 17 217 4 6292
    signaling process 2.2987E-3 17 217 4 6292
    regulation of conjugation with cellular fusion by signal transduction 2.318E-3 17 27 2 6292
    pheromone-dependent signal transduction involved in conjugation with cellular fusion 2.318E-3 17 27 2 6292
    cellular response to stimulus 2.6129E-3 17 379 5 6292
    intracellular accumulation of glycerol 2.7018E-3 17 1 1 6292
    cellular hyperosmotic response 2.7018E-3 17 1 1 6292
    G-protein coupled receptor protein signaling pathway 3.0514E-3 17 31 2 6292
    response to temperature stimulus 3.0514E-3 17 31 2 6292
    regulation of multi-organism process 3.2496E-3 17 32 2 6292
    regulation of conjugation 3.2496E-3 17 32 2 6292
    regulation of conjugation with cellular fusion 3.2496E-3 17 32 2 6292
    cell surface receptor linked signaling pathway 3.2496E-3 17 32 2 6292
    response to abiotic stimulus 3.5229E-3 17 117 3 6292
    signaling 3.9576E-3 17 252 4 6292
    cell morphogenesis 4.2461E-3 17 125 3 6292
    regulation of cell cycle 4.8439E-3 17 131 3 6292
    double-strand break repair via single-strand annealing, removal of nonhomologous ends 5.3968E-3 17 2 1 6292
    nucleotide-excision repair, DNA incision, 5'-to lesion 5.3968E-3 17 2 1 6292
    arginine catabolic process 5.3968E-3 17 2 1 6292
    nicotinamide nucleotide metabolic process 5.8138E-3 17 43 2 6292
    pyridine nucleotide metabolic process 6.6321E-3 17 46 2 6292
    cell cycle process 7.9048E-3 17 490 5 6292
    snRNA processing 8.0849E-3 17 3 1 6292
    nucleotide-excision repair, DNA incision 8.0849E-3 17 3 1 6292
    organelle fusion 9.0541E-3 17 54 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase inhibitor activity 2.668E-6 17 11 3 6292
    kinase inhibitor activity 2.668E-6 17 11 3 6292
    glycerol-3-phosphate dehydrogenase (NAD+) activity 6.8716E-6 17 2 2 6292
    enzyme inhibitor activity 4.6048E-5 17 27 3 6292
    protein kinase regulator activity 2.315E-4 17 46 3 6292
    kinase regulator activity 2.7957E-4 17 49 3 6292
    ornithine-oxo-acid transaminase activity 2.7018E-3 17 1 1 6292
    ATP-dependent protein binding 2.7018E-3 17 1 1 6292
    RNA polymerase II transcription termination factor activity 2.7018E-3 17 1 1 6292
    transcription termination factor activity 5.3968E-3 17 2 1 6292
    cyclin-dependent protein kinase inhibitor activity 8.0849E-3 17 3 1 6292

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