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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Dbp8. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • CDC15
  • cellular bud neck
  • spindle pole body
  • regulation of exit from mitosis
  • cytokinesis
  • protein amino acid phosphorylation
  • protein kinase activity
  • CPA2
  • carbamoyl-phosphate synthase complex
  • arginine biosynthetic process
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
  • DBP8
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ATP-dependent RNA helicase activity
  • HEF3
  • cytosolic ribosome
  • translational elongation
  • ATPase activity
  • translation elongation factor activity
  • KGD1
  • mitochondrial matrix
  • mitochondrial oxoglutarate dehydrogenase complex
  • mitochondrion
  • mitochondrial nucleoid
  • tricarboxylic acid cycle
  • 2-oxoglutarate metabolic process
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • PFK1
  • 6-phosphofructokinase complex
  • cytoplasm
  • mitochondrion
  • glycolysis
  • 6-phosphofructokinase activity
  • PGM2
  • cytosol
  • response to temperature stimulus
  • energy reserve metabolic process
  • UDP-glucose metabolic process
  • trehalose biosynthetic process
  • alcohol metabolic process
  • glucose metabolic process
  • cellular calcium ion homeostasis
  • vacuolar protein catabolic process
  • carbohydrate metabolic process
  • glycogen biosynthetic process
  • glucose 6-phosphate metabolic process
  • cellular carbohydrate metabolic process
  • galactose catabolic process
  • glucose 1-phosphate metabolic process
  • cellular cation homeostasis
  • phosphoglucomutase activity
  • RNR1
  • cytoplasm
  • ribonucleoside-diphosphate reductase complex
  • DNA replication
  • telomere maintenance
  • ribonucleoside-diphosphate reductase activity
  • RNR2
  • nucleus
  • cytoplasm
  • ribonucleoside-diphosphate reductase complex
  • DNA replication
  • ribonucleoside-diphosphate reductase activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • SEC26
  • coated vesicle
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • molecular_function
  • THI22
  • cellular_component
  • thiamin biosynthetic process
  • phosphomethylpyrimidine kinase activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • YDL086W
  • cytoplasm
  • mitochondrion
  • biological_process
  • carboxymethylenebutenolidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribonucleoside-diphosphate reductase complex 3.6271E-5 16 4 2 6292
    cytoplasmic part 7.9119E-4 16 2482 13 6292
    plasma membrane enriched fraction 2.5429E-3 16 1 1 6292
    protein complex 3.6103E-3 16 1137 8 6292
    carbamoyl-phosphate synthase complex 5.0798E-3 16 2 1 6292
    6-phosphofructokinase complex 5.0798E-3 16 2 1 6292
    mitochondrial oxoglutarate dehydrogenase complex 7.6106E-3 16 3 1 6292
    oxoglutarate dehydrogenase complex 7.6106E-3 16 3 1 6292
    cytoplasm 8.9496E-3 16 3552 14 6292
    macromolecular complex 9.6949E-3 16 1635 9 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    arginine metabolic process 7.1262E-4 16 16 2 6292
    small molecule catabolic process 3.5478E-3 16 125 3 6292
    arginine catabolic process 5.0798E-3 16 2 1 6292
    glucose 1-phosphate metabolic process 5.0798E-3 16 2 1 6292
    glucose 6-phosphate metabolic process 5.0798E-3 16 2 1 6292
    2-oxoglutarate metabolic process 5.0798E-3 16 2 1 6292
    glutamine family amino acid metabolic process 5.1521E-3 16 43 2 6292
    catabolic process 6.2718E-3 16 496 5 6292
    hexose catabolic process 6.6504E-3 16 49 2 6292
    UDP-glucose metabolic process 7.6106E-3 16 3 1 6292
    monosaccharide catabolic process 8.0328E-3 16 54 2 6292
    small molecule metabolic process 8.3617E-3 16 760 6 6292
    alcohol catabolic process 8.9193E-3 16 57 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    catalytic activity 1.0668E-6 16 2150 15 6292
    oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 3.6271E-5 16 4 2 6292
    ribonucleoside-diphosphate reductase activity 3.6271E-5 16 4 2 6292
    oxidoreductase activity, acting on CH or CH2 groups 6.0363E-5 16 5 2 6292
    ATP-dependent RNA helicase activity 2.2052E-3 16 28 2 6292
    RNA-dependent ATPase activity 2.365E-3 16 29 2 6292
    ornithine-oxo-acid transaminase activity 2.5429E-3 16 1 1 6292
    carboxymethylenebutenolidase activity 2.5429E-3 16 1 1 6292
    oxidoreductase activity 4.6277E-3 16 281 4 6292
    RNA helicase activity 4.9198E-3 16 42 2 6292
    phosphoglucomutase activity 5.0798E-3 16 2 1 6292
    oxoglutarate dehydrogenase (succinyl-transferring) activity 5.0798E-3 16 2 1 6292
    6-phosphofructokinase activity 5.0798E-3 16 2 1 6292
    NADPH dehydrogenase activity 5.0798E-3 16 2 1 6292
    translation factor activity, nucleic acid binding 5.3895E-3 16 44 2 6292
    ATP-dependent helicase activity 6.3884E-3 16 48 2 6292
    purine NTP-dependent helicase activity 6.3884E-3 16 48 2 6292
    carbamoyl-phosphate synthase activity 7.6106E-3 16 3 1 6292
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 7.6106E-3 16 3 1 6292
    phosphomethylpyrimidine kinase activity 7.6106E-3 16 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle