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null null Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin. null Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ribonucleoside-diphosphate reductase activity
Acc: GO:0004748
Aspect: Molecular Function
Desc: Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
Synonyms:
  • nucleoside diphosphate reductase activity
  • ribonucleoside 5'-diphosphate reductase activity
  • ribonucleoside diphosphate reductase activity
  • purine/pyrimidine nucleoside diphosphate reduction
  • RNR
  • 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
  • ribonucleotide reductase activity
  • 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
  • ribonucleotide diphosphate reductase activity
Proteins in PDR annotated with:
   This term: 56 [Search]
   Term or descendants: 61 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004748 - ribonucleoside-diphosphate reductase activity (interactive image map)
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