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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • MAK5
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.6603E-23 15 211 15 6292
    nuclear lumen 5.8229E-18 15 453 15 6292
    organelle lumen 1.7741E-15 15 660 15 6292
    intracellular organelle lumen 1.7741E-15 15 660 15 6292
    membrane-enclosed lumen 4.3281E-15 15 700 15 6292
    non-membrane-bounded organelle 5.0689E-13 15 959 15 6292
    intracellular non-membrane-bounded organelle 5.0689E-13 15 959 15 6292
    nuclear part 4.193E-12 15 1103 15 6292
    nucleus 4.4738E-8 15 2041 15 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    organelle part 2.3996E-7 15 2282 15 6292
    Noc1p-Noc2p complex 5.3053E-6 15 2 2 6292
    Noc complex 5.2834E-5 15 5 2 6292
    preribosome, large subunit precursor 1.8916E-4 15 9 2 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    90S preribosome 7.0676E-4 15 17 2 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292
    preribosome 2.8479E-3 15 34 2 6292
    Noc2p-Noc3p complex 4.7627E-3 15 2 1 6292
    nucleolar part 4.9503E-3 15 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 9.5036E-20 15 346 15 6292
    ribonucleoprotein complex biogenesis 3.1258E-19 15 374 15 6292
    ribosomal large subunit biogenesis 3.5997E-15 15 65 9 6292
    cellular component biogenesis 3.7988E-15 15 694 15 6292
    ribosome assembly 4.8581E-11 15 64 7 6292
    organelle assembly 8.3901E-11 15 69 7 6292
    ribosomal large subunit assembly 2.5073E-10 15 41 6 6292
    ribonucleoprotein complex assembly 6.6388E-10 15 92 7 6292
    ribosomal subunit assembly 1.5888E-9 15 55 6 6292
    cellular macromolecular complex assembly 7.9917E-8 15 182 7 6292
    rRNA processing 2.7153E-7 15 128 6 6292
    rRNA metabolic process 4.0686E-7 15 137 6 6292
    cellular macromolecular complex subunit organization 8.9573E-7 15 259 7 6292
    macromolecular complex assembly 1.5553E-6 15 281 7 6292
    ncRNA processing 5.741E-6 15 215 6 6292
    macromolecular complex subunit organization 7.7325E-6 15 357 7 6292
    cellular component assembly 1.2752E-5 15 385 7 6292
    ncRNA metabolic process 1.6069E-5 15 257 6 6292
    RNA processing 1.4636E-4 15 380 6 6292
    processing of 27S pre-rRNA 6.2447E-4 15 16 2 6292
    RNA metabolic process 3.7928E-3 15 954 7 6292
    cellular process 5.0732E-3 15 4426 15 6292
    obsolete_biological_process 8.6698E-3 15 60 2 6292
    organelle organization 9.8079E-3 15 1127 7 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    rRNA binding 6.027E-6 15 16 3 6292
    ATP-dependent RNA helicase activity 3.4657E-5 15 28 3 6292
    RNA-dependent ATPase activity 3.8601E-5 15 29 3 6292
    rRNA primary transcript binding 5.2834E-5 15 5 2 6292
    RNA helicase activity 1.1904E-4 15 42 3 6292
    RNA binding 1.206E-4 15 367 6 6292
    ATP-dependent helicase activity 1.778E-4 15 48 3 6292
    purine NTP-dependent helicase activity 1.778E-4 15 48 3 6292
    helicase activity 8.9828E-4 15 83 3 6292
    nucleic acid binding 2.9734E-3 15 666 6 6292
    5S rRNA binding 4.7627E-3 15 2 1 6292
    ATPase activity, coupled 4.8042E-3 15 149 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle