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Protein Overview: SMC6

General Information:
Name(s) found: SMC6 / YLR383W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1114 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Smc5-Smc6 complex [IPILink to PubMed articleLink to PubMed article]
    Biological Process: cell proliferation [IDALink to PubMed article]
    DNA repair [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISTTISGKR PIEQVDDELL SLTAQQENEE QQQQRKRRRH QFAPMTQFNS NTLDEDSGFR  60
   61 SSSDVATADQ DNFLEESPSG YIKKVILRNF MCHEHFELEL GSRLNFIVGN NGSGKSAILT 120
  121 AITIGLGAKA SETNRGSSLK DLIREGCYSA KIILHLDNSK YGAYQQGIFG NEIIVERIIK 180
  181 RDGPASFSLR SENGKEISNK KKDIQTVVDY FSVPVSNPMC FLSQDAARSF LTASTSQDKY 240
  241 SHFMKGTLLQ EITENLLYAS AIHDSAQENM ALHLENLKSL KAEYEDAKKL LRELNQTSDL 300
  301 NERKMLLQAK SLWIDVAHNT DACKNLENEI SGIQQKVDEV TEKIRNRQEK IERYTSDGTT 360
  361 IEAQIDAKVI YVNEKDSEHQ NARELLRDVK SRFEKEKSNQ AEAQSNIDQG RKKVDALNKT 420
  421 IAHLEEELTK EMGGDKDQMR QELEQLEKAN EKLREVNNSL VVSLQDVKNE ERDIQHERES 480
  481 ELRTISRSIQ NKKVELQNIA KGNDTFLMNF DRNMDRLLRT IEQRKNEFET PAIGPLGSLV 540
  541 TIRKGFEKWT RSIQRAISSS LNAFVVSNPK DNRLFRDIMR SCGIRSNIPI VTYCLSQFDY 600
  601 SKGRAHGNYP TIVDALEFSK PEIECLFVDL SRIERIVLIE DKNEARNFLQ RNPVNVNMAL 660
  661 SLRDRRSGFQ LSGGYRLDTV TYQDKIRLKV NSSSDNGTQY LKDLIEQETK ELQNIRDRYE 720
  721 EKLSEVRSRL KEIDGRLKST KNEMRKTNFR MTELKMNVGK VVDTGILNSK INERKNQEQA 780
  781 IASYEAAKEE LGLKIEQIAQ EAQPIKEQYD STKLALVEAQ DELQQLKEDI NSRQSKIQKY 840
  841 KDDTIYYEDK KKVYLENIKK IEVNVAALKE GIQRQIQNAC AFCSKERIEN VDLPDTQEEI 900
  901 KRELDKVSRM IQKAEKSLGL SQEEVIALFE KCRNKYKEGQ KKYMEIDEAL NRLHNSLKAR 960
  961 DQNYKNAEKG TCFDADMDFR ASLKVRKFSG NLSFIKDTKS LEIYILTTND EKARNVDTLS1020
 1021 GGEKSFSQMA LLLATWKPMR SRIIALDEFD VFMDQVNRKI GTTLIVKKLK DIARTQTIII1080
 1081 TPQDIGKIAD IDSSGVSIHR MRDPERQNNS NFYN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Hazbun TR, et al. (2003) KRE29 MMS21 NSE1 NSE3 NSE4 NSE5 SMC5 SMC6
    View Details Ho Y, et al. (2002) HHF1, HHF2 IMD1 IMD4 SMC6 SRP1
    View Details Qiu et al. (2008) NSE1 NSE3 NSE5 SMC5 SMC6

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run SMC5 No Comments Hazbun TR, et al. (2003)
    View Run NSE3 No Comments Hazbun TR, et al. (2003)
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run NSE3 No Comments Hazbun TR, et al. (2003)
    View Run SMC5 No Comments Hazbun TR, et al. (2003)
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SMC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] deduced N/A No confident structure predictions are available.
    2 View Details [70..171] PSI-BLAST 43.201249 Rad50
    3 View Details [172..506] PSI-BLAST 17.09691 Heavy meromyosin subfragment
    4 View Details [507..538]
    [562..594]    		 ORFEUS 7.56 Smc hinge domain
    5 View Details [539..561]
    [595..598]
    [616..634]
    [676..716]    		 ORFEUS 7.56 Smc hinge domain
    6 View Details [599..615]
    [635..675]    		 ORFEUS 7.56 Smc hinge domain
    7 View Details [717..772] PSI-BLAST 9.522879 Tropomyosin
    8 View Details [773..854] PSI-BLAST 9.522879 Tropomyosin
    9 View Details [855..917] PSI-BLAST 9.522879 Tropomyosin
    10 View Details [918..1009] PSI-BLAST 9.522879 Tropomyosin
    11 View Details [1010..1114] PSI-BLAST 55.30103 Smc head domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.91859588671053 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.95771648771351 bayes_pls_golite062009
  • DNA binding
    		•  1.93187483871367 bayes_pls_golite062009
  • protein binding
    		•  1.02696508439754 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.763090239384034 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.70383800342119 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.558475595998159 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.470856513541915 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.402077983920615 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  0.308074321526054 bayes_pls_golite062009
  • catalytic activity
    		•  0.265320175609019 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle