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View Structure Prediction Details

Protein: SMC6
Organism: Saccharomyces cerevisiae
Length: 1114 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMC6.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [115..1029] [843..1817]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 1.0E-99 [115..1029] [846..1820]
gi|9800488, gi|1... - gi|9800488|gb|AAF99315.1|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi|165973976|...
 1.0E-98 [40..1029] [771..1820]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
 4.0E-98 [115..1029] [844..1818]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
 7.0E-98 [115..1029] [845..1819]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 8.0E-98 [40..1029] [768..1817]

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Predicted Domain #1
Region A:
Residues: [1-69] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISTTISGKR PIEQVDDELL SLTAQQENEE QQQQRKRRRH QFAPMTQFNS NTLDEDSGFR  60
   61 SSSDVATAD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [70-171] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDNFLEESPS GYIKKVILRN FMCHEHFELE LGSRLNFIVG NNGSGKSAIL TAITIGLGAK  60
   61 ASETNRGSSL KDLIREGCYS AKIILHLDNS KYGAYQQGIF GN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.201249
Match: 1f2tA_
Description: Rad50
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [172-506] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIIVERIIKR DGPASFSLRS ENGKEISNKK KDIQTVVDYF SVPVSNPMCF LSQDAARSFL  60
   61 TASTSQDKYS HFMKGTLLQE ITENLLYASA IHDSAQENMA LHLENLKSLK AEYEDAKKLL 120
  121 RELNQTSDLN ERKMLLQAKS LWIDVAHNTD ACKNLENEIS GIQQKVDEVT EKIRNRQEKI 180
  181 ERYTSDGTTI EAQIDAKVIY VNEKDSEHQN ARELLRDVKS RFEKEKSNQA EAQSNIDQGR 240
  241 KKVDALNKTI AHLEEELTKE MGGDKDQMRQ ELEQLEKANE KLREVNNSLV VSLQDVKNEE 300
  301 RDIQHERESE LRTISRSIQN KKVELQNIAK GNDTF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.09691
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.91859588671053 bayes_pls_golite062009
nucleic acid binding 1.95771648771351 bayes_pls_golite062009
DNA binding 1.93187483871367 bayes_pls_golite062009
protein binding 1.02696508439754 bayes_pls_golite062009
protein dimerization activity 0.763090239384034 bayes_pls_golite062009
structure-specific DNA binding 0.70383800342119 bayes_pls_golite062009
protein heterodimerization activity 0.558475595998159 bayes_pls_golite062009
double-stranded DNA binding 0.470856513541915 bayes_pls_golite062009
sequence-specific DNA binding 0.402077983920615 bayes_pls_golite062009
DNA secondary structure binding 0.308074321526054 bayes_pls_golite062009
catalytic activity 0.265320175609019 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [507-538] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMNFDRNMDR LLRTIEQRKN EFETPAIGPL GS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [562-594] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAFVVSNPKD NRLFRDIMRS CGIRSNIPIV TYC

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.56
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [539-561] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVTIRKGFEK WTRSIQRAIS SSL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [595-598] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSQF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [616-634] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEFSKPEIEC LFVDLSRIE

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [676-716] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLDTVTYQDK IRLKVNSSSD NGTQYLKDLI EQETKELQNI R

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.56
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [599-615] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYSKGRAHGN YPTIVDA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [635-675] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIVLIEDKNE ARNFLQRNPV NVNMALSLRD RRSGFQLSGG Y

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.56
Match: 1gxlA
Description: Smc hinge domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [717-772] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRYEEKLSEV RSRLKEIDGR LKSTKNEMRK TNFRMTELKM NVGKVVDTGI LNSKIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [773-854] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERKNQEQAIA SYEAAKEELG LKIEQIAQEA QPIKEQYDST KLALVEAQDE LQQLKEDINS  60
   61 RQSKIQKYKD DTIYYEDKKK VY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #9
Region A:
Residues: [855-917] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LENIKKIEVN VAALKEGIQR QIQNACAFCS KERIENVDLP DTQEEIKREL DKVSRMIQKA  60
   61 EKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [918-1009] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGLSQEEVIA LFEKCRNKYK EGQKKYMEID EALNRLHNSL KARDQNYKNA EKGTCFDADM  60
   61 DFRASLKVRK FSGNLSFIKD TKSLEIYILT TN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #11
Region A:
Residues: [1010-1114] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEKARNVDTL SGGEKSFSQM ALLLATWKPM RSRIIALDEF DVFMDQVNRK IGTTLIVKKL  60
   61 KDIARTQTII ITPQDIGKIA DIDSSGVSIH RMRDPERQNN SNFYN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.30103
Match: 1e69A_
Description: Smc head domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle