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Protein Overview: SIS2

General Information:
Name(s) found: SIS2 / YKR072C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 562 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IPILink to PubMed article]
    cytoplasm [ICLink to PubMed article][IPILink to PubMed article]
    Biological Process: response to salt stress [IGILink to PubMed article][IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [IGILink to PubMed article]
    coenzyme A biosynthetic process [ISSLink to PubMed article]
    regulation of mitotic cell cycle [IGILink to PubMed article]
    Molecular Function: phosphopantothenoylcysteine decarboxylase activity [ISSLink to PubMed article]
    phosphoprotein phosphatase inhibitor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAVASTSGK QDADHNQSIE CPRFSRGQKE ILLDHEDAKG KDSIINSPVS GRQSISPTLS  60
   61 NATTTTTKSI MNATGTSGAV VSNTPEPGLK RVPAVTFSDL KQQQKQDSLT QLKNDSERTK 120
  121 SPNSNPAPVS NSIPGNHAVI PNHTNTSRTT QLSGSPLVNE MKDYDPKKKD SALKIVDTMK 180
  181 PDKIMATSTP ISRENNKVTA KAPTSITLRK EDAQDQANNV SGQINVRSTP EETPVKQSVI 240
  241 PSIIPKRENS KNLDPRLPQD DGKLHVLFGA TGSLSVFKIK PMIKKLEEIY GRDRISIQVI 300
  301 LTQSATQFFE QRYTKKIIKS SEKLNKMSQY ESTPATPVTP TPGQCNMAQV VELPPHIQLW 360
  361 TDQDEWDAWK QRTDPVLHIE LRRWADILVV APLTANTLSK IALGLCDNLL TSVIRAWNPS 420
  421 YPILLAPSMV SSTFNSMMTK KQLQTIKEEM SWVTVFKPSE KVMDINGDIG LGGMMDWNEI 480
  481 VNKIVMKLGG YPKNNEEEDD DEDEEEDDDE EEDTEDKNEN NNDDDDDDDD DDDDDDDDDD 540
  541 DDDDDDEDED EAETPGIIDK HQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAB3 SIS2 VHS3
    View Details Hazbun TR, et al. (2003) CAB3 SIS2 VHS3
    View Details Krogan NJ, et al. (2006) MNS1 RDH54 SIS2 TRM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..283] MSA 80.222997 View MSA. No confident structure predictions are available.
    2 View Details [284..562] PSI-BLAST 371.274545 4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphopantothenoylcysteine decarboxylase activity
    		•  3.86093811191169 bayes_pls_golite062009
  • phosphopantothenate--cysteine ligase activity
    		•  2.64345867885176 bayes_pls_golite062009
  • binding
    		•  1.79334633421708 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.79168084682693 bayes_pls_golite062009
  • catalytic activity
    		•  1.51672397362026 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  1.03827559540394 bayes_pls_golite062009
  • protein binding
    		•  0.359358565373414 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle