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View Structure Prediction Details

Protein: SIS2
Organism: Saccharomyces cerevisiae
Length: 562 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIS2.

Description E-value Query
Range
Subject
Range
SIS2_YEAST - Phosphopantothenoylcysteine decarboxylase subunit SIS2 OS=Saccharomyces cerevisiae (strain ATCC 2045...
SIS2 - Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothe...
0.0 [1..562] [1..562]
gi|8778701 - gi|8778701|gb|AAF79709.1|AC020889_17 T1N15.24 [Arabidopsis thaliana]
4.0E-82 [57..502] [1..464]
TYSY_SCHPO - Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 ...
SPAC15E1.04 - thymidylate synthase
6.0E-64 [243..511] [10..244]
CE09663 - Yeast hypothetical 65.2 KD protein like status:Confirmed UniProt:P91988 protein_id:CAB02993.1
5.0E-63 [226..491] [8..229]
SIS2_CANTR - Protein SIS2 OS=Candida tropicalis GN=SIS2 PE=3 SV=1
4.0E-60 [32..492] [41..462]
PPCDC - phosphopantothenoylcysteine decarboxylase
gi|123982788, gi... - gi|123997459|gb|ABM86331.1| phosphopantothenoylcysteine decarboxylase [synthetic construct], gi|1239...
1.0E-59 [247..492] [1..199]

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Predicted Domain #1
Region A:
Residues: [1-283]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAVASTSGK QDADHNQSIE CPRFSRGQKE ILLDHEDAKG KDSIINSPVS GRQSISPTLS  60
   61 NATTTTTKSI MNATGTSGAV VSNTPEPGLK RVPAVTFSDL KQQQKQDSLT QLKNDSERTK 120
  121 SPNSNPAPVS NSIPGNHAVI PNHTNTSRTT QLSGSPLVNE MKDYDPKKKD SALKIVDTMK 180
  181 PDKIMATSTP ISRENNKVTA KAPTSITLRK EDAQDQANNV SGQINVRSTP EETPVKQSVI 240
  241 PSIIPKRENS KNLDPRLPQD DGKLHVLFGA TGSLSVFKIK PMI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [284-562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKLEEIYGRD RISIQVILTQ SATQFFEQRY TKKIIKSSEK LNKMSQYEST PATPVTPTPG  60
   61 QCNMAQVVEL PPHIQLWTDQ DEWDAWKQRT DPVLHIELRR WADILVVAPL TANTLSKIAL 120
  121 GLCDNLLTSV IRAWNPSYPI LLAPSMVSST FNSMMTKKQL QTIKEEMSWV TVFKPSEKVM 180
  181 DINGDIGLGG MMDWNEIVNK IVMKLGGYPK NNEEEDDDED EEEDDDEEED TEDKNENNND 240
  241 DDDDDDDDDD DDDDDDDDDD DDDEDEDEAE TPGIIDKHQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 371.274545
Match: 1e20A_
Description: 4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphopantothenoylcysteine decarboxylase activity 3.86093811191169 bayes_pls_golite062009
phosphopantothenate--cysteine ligase activity 2.64345867885176 bayes_pls_golite062009
binding 1.79334633421708 bayes_pls_golite062009
carboxy-lyase activity 1.79168084682693 bayes_pls_golite062009
catalytic activity 1.51672397362026 bayes_pls_golite062009
carbon-carbon lyase activity 1.03827559540394 bayes_pls_golite062009
protein binding 0.359358565373414 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle