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Protein Overview: STN1

General Information:
Name(s) found: STN1 / YDR082W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 494 amino acids

    Gene Ontology:
    Cellular Component: nuclear telomere cap complex [TASLink to PubMed article]
    Biological Process: telomere capping [TASLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]
    telomeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKYGHIAHQ EGDVCYYIPR LFKYNSYYSG TEDVRIFVGD LKYRMRVSLQ ICEKYYDRRL  60
   61 SMLFWKNHPL QQIHLIGCII GLQFKWIGKQ EYIFFQLDDC TSDSSLVGYT SDMRFLTCKV 120
  121 KKDSILSWGL NITDLIGLTL HVYGQASLNY QELQVEYLRL CYSLTEEIDH WKITMNMREQ 180
  181 LDTPWSLSDF VIGELFTQEQ EWTPETSQIE VVNPDFVGIG YKTPESKRNE TTFIEQLQEE 240
  241 RLKDELEIIS PYNSTDTSNS VHSLSFRFVS SLKDFPETHF LNSGDQIDNG NDEQLKKLEY 300
  301 QSANLPVMIP NRTSAKSNLM LILLGLQMKE ISNSDLYKLK EVRSVVTSLA SFLFQQQNVG 360
  361 VMKSFDSLEK EAFRDLVNRL VSQGLIGLKD KTSETFDLLP LKNLFEYAEK RISVLMKLQC 420
  421 YTGTVQLSHV QEKLHLPYIT TNGIVDVFKE CLKRTKKQYP EVLKNWWIDL DPKNGMEDQN 480
  481 SGILLHLEYA AAYS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CDC13 RAP1 STN1 TEN1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC13 STN1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..494] deduced N/A No confident structure predictions are available.
    2 View Details [311..494] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • telomerase inhibitor activity
    		•  7.4045795951838 bayes_pls_golite062009
  • telomeric DNA binding
    		•  6.80354805962079 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  6.768584842828 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.7851057288689 bayes_pls_golite062009
  • DNA binding
    		•  3.36845392994723 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  3.18920599157105 bayes_pls_golite062009
  • binding
    		•  2.75191943661749 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.74795067107907 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.64392934015868 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.93610624899943 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.87401014198878 bayes_pls_golite062009
  • structural molecule activity
    		•  1.75354740531381 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.11970004248085 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.03434608237928 bayes_pls_golite062009
  • transcription factor activity
    		•  0.967319786833633 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.753061173202428 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.633347054314125 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.451086694866543 bayes_pls_golite062009
  • nuclease activity
    		•  0.344602655860014 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.327087435405429 bayes_pls_golite062009
  • translation regulator activity
    		•  0.272395932340767 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.224702431869342 bayes_pls_golite062009
  • protein binding
    		•  0.185497104009134 bayes_pls_golite062009
  • exonuclease activity
    		•  0.123437412322173 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle