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Protein Overview: gi|45447058, gi|...

General Information:
Name(s) found: gi|45551482 [NCBI NR]
gi|45447058 [NCBI NR]
Description(s) found:
Found 7 descriptions.
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  • gi|45551482|ref|NP_728239.2| giant fibre A, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45447058|gb|AAF48950.3| giant fibre A, isoform B [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 541 amino acids

    Gene Ontology:
    Cellular Component: dendrite [IDA]
    postsynaptic membrane [IEA]
    dendritic spine [IDA]
    integral to membrane [IEA]
    nicotinic acetylcholine-gated receptor-channel complex [ISS][NAS]
    Biological Process: ion transport [IEA]
    regulation of excitatory postsynaptic membrane potential [IMP]
    jump response [IMP]
    synaptic transmission [IMP]
    visual behavior [IMP]
    Molecular Function: nicotinic acetylcholine-activated cation-selective channel activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCRVPCIKFL EPAVSNCANS QMIVQSVLME LVFHSCAAGP HEKRLLHALL DNYNSLERPV  60
   61 VNESDPLQLS FGLTLMQIID VDEKNQLLIT NIWLKLEWND MNLRWNSSEF GGVRDLRIPP 120
  121 HRLWKPDVLM YNSADEGFDG TYATNVVVRN NGSCLYVPPG IFKSTCKIDI TWFPFDDQRC 180
  181 EMKFGSWTYD GFQLDLQLQD EAGGDISSFI TNGEWDLLGV PGKRNEIYYN CCPEPYIDIT 240
  241 FAILIRRKTL YYFFNLIVPC VLIASMALLG FTLPPDSGEK LSLGVTILLS LTVFLNMVAE 300
  301 TMPATSDAVP LLGTYFNCIM FMVASSVVST ILILNYHHRN PDTHEMSEWI RVIFLYWLPC 360
  361 ILRMQRPGQV GYECPPPPSS SSSSASGEKK QQIQNVELKE RSSKSLLANV LDIDDDFRCN 420
  421 HRCASATLPH QPTYYRTMYR QGDDGSVGPV GPAGPVVDGR LHEAISHTCL TSSAEYELAL 480
  481 ILKELRWITE QLKKEDETSD ITRDWKFAAM VVDRLCLIIF TLFTIIATLA VLFSAPHFIF 540
  541 P

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..365] PSI-BLAST 79.0 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [366..541] PSI-BLAST 43.69897 Acetylcholine receptor protein, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • acetylcholine binding
    		•  13.9752632471881 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  13.7533645836795 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  13.1511875247796 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  11.9525876011069 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  11.7813202122163 bayes_pls_golite062009
  • cation channel activity
    		•  11.7442066737514 bayes_pls_golite062009
  • ion channel activity
    		•  11.1753684044644 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  11.0903806681397 bayes_pls_golite062009
  • channel activity
    		•  11.0903806681397 bayes_pls_golite062009
  • gated channel activity
    		•  11.0397691626728 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  10.9375522860542 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • amine binding
    		•  9.11982124959723 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  9.10587892909341 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  7.22265353460749 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  7.19173677417054 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.7875346065164 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.4080353535498 bayes_pls_golite062009
  • receptor activity
    		•  5.11329651194787 bayes_pls_golite062009
  • transporter activity
    		•  5.11262082564788 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.03439798256257 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.91314874981447 bayes_pls_golite062009
  • neurotransmitter binding
    		•  4.25797760547212 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  4.15404686068319 bayes_pls_golite062009
  • signal transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • binding
    		•  2.4916526322278 bayes_pls_golite062009
  • adenylate cyclase binding
    		•  2.44136378171826 bayes_pls_golite062009
  • beta-amyloid binding
    		•  2.25766805801029 bayes_pls_golite062009
    		• 1.68370717591127 bayes_pls_golite062009
  • channel regulator activity
    		•  1.66978990310631 bayes_pls_golite062009
  • protein binding
    		•  1.45740893920165 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.42422063123689 bayes_pls_golite062009
  • serotonin binding
    		•  1.33584589886834 bayes_pls_golite062009
  • serotonin-activated cation-selective channel activity
    		•  1.31324203158511 bayes_pls_golite062009
  • toxin binding
    		•  1.03329843925063 bayes_pls_golite062009
  • drug binding
    		•  0.64715018605883 bayes_pls_golite062009
  • kinase binding
    		•  0.365355763029699 bayes_pls_golite062009
  • protein kinase binding
    		•  0.350601457777817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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