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Protein Overview: CG17922-PA

General Information:
Name(s) found: CG17922-PA / FBpp0071592 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG17922 (CG17922, FBgn0034656). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17580191..17584657. It has the cytological map location 57F9. Based on sequence similarity, it is predicted to have molecular function</span>: intracellular cyclic nucleotide activated cation channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: transmembrane transport; ion transport. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1040 amino acids

    Gene Ontology:
    Cellular Component: intracellular cyclic nucleotide activated cation channel complex [ISS]
    Biological Process: ion transport [IEA]
    transmembrane transport [IEA]
    Molecular Function: intracellular cyclic nucleotide activated cation channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSMARFRKV NRQSEKLEPE ASASLLKSSP NILENFAYDE FQPIQTNHPL LKRMATTPVA  60
   61 QSGSQSSSSS TSSTRKAEPK FCDTLERHAF MRNVINQQPE STRRYSTPGE KEAQVRRSLE 120
  121 EITKDLKEIE QFVSATEELM QREKEQEQMM YSNKENKCPS PVKRVTYKIN AYKAPPRRHR 180
  181 PGSPRFYHSR LYFRNGKIGC VDSTEHQNNV GATHALVKHI LHHEKPLVSP DSVRRVLEQD 240
  241 SFEMVPLPGA VPEIVPDPIA IQRAEELAAA TGQVVLPKEE EEEEKSSPLH QVESQPDVDE 300
  301 DEQDVQICYN ESPELQNEDR NERTQRTPSI NESEIVAVDE PDTEMNSDVD HRKPSSAGSL 360
  361 DSQGQQFLRD QVRHLVRRFT ARANKVKSRI ELPPTPSSSS TVSSPSPPPT KSLHPSPQHK 420
  421 VRLVPAGQSP HRGRLFEADT PRSNVWLCSS LCGANNDERT LDPQGKIYIS WLCVVSLSFL 480
  481 YNAWVIPLRA SFPFQTKENT NIWLACDFCA DIIYLLDVVF FKHRVMYLFE GFWVKNKNLT 540
  541 RKNYMRKLQF KLDLLALLPL ELLYFKLGTQ AVWLRFPRFF KIQSFWEVFR LLDRVISSPH 600
  601 FVRVAKTLTY MLYMIHITAA LYYAYSDYQG LGQNRWVFSG KGHPYVRCFA FATKTATSIG 660
  661 KNPKPERQGE YVFMTVAWLM GVFVFALLIG QIRDIISTAT RNKHEYRQLE DETLEYMRRL 720
  721 NLSQEVQSRV KMWFQFTWEQ QRTLDESNIL DALPINLKTD IAISVHIQTL SKVQLFADCE 780
  781 EALLRDLVLK LRAVTFLPGD FVCRKGEVGR EMYIVKLGQV QVMGGPSSDV VLATLTEGSV 840
  841 FGEISLLGIN GADRRTADVR SKGYSNLFVL SKSDLNEVIA YYPTAQAILK KRARQLMRKN 900
  901 AAREREEERE RARSALQADV VIGNPKTPET APKLLQTVIQ ALPFESPAVV LITRGSKRMR 960
  961 RKRQSVQMET IVEPKMEVTG AAETQDQKGL KTGRCSPDLL SSIQQELKSK HKFINLTDSE1020
 1021 KALISQSANN SLEDMKVVDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] deduced N/A No confident structure predictions are available.
    2 View Details [97..306] MSA 6.316995 View MSA. No confident structure predictions are available.
    3 View Details [307..742] PSI-BLAST 27.0 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    4 View Details [743..915] PSI-BLAST 31.522879 HCN2J 443-645 in the presence of cGMP
    5 View Details [916..1040] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • ion channel activity
    		•  8.54258173089828 bayes_pls_golite062009
  • gated channel activity
    		•  8.40583491856766 bayes_pls_golite062009
  • channel activity
    		•  8.39905773163311 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  8.39905773163311 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  8.39470084162975 bayes_pls_golite062009
  • cation channel activity
    		•  8.37340171056317 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.27305202954784 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.92543918512794 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.90247452112447 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  3.17407714154852 bayes_pls_golite062009
  • potassium channel activity
    		•  3.16645830461177 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.68223244325599 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.45301353888223 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.42821009576643 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.29036912617062 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.1888705807099 bayes_pls_golite062009
  • binding
    		•  1.39247933044015 bayes_pls_golite062009
  • protein binding
    		•  0.71319432010926 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.685020633246238 bayes_pls_golite062009
  • signal transducer activity
    		•  0.685020633246238 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.362412435891451 bayes_pls_golite062009
  • transporter activity
    		•  0.0214385136840991 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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