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View Structure Prediction Details

Protein: CG17922-PA
Organism: Drosophila melanogaster
Length: 1040 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG17922-PA.

Description E-value Query
Range
Subject
Range
CNGA1_MOUSE - cGMP-gated cation channel alpha-1 OS=Mus musculus GN=Cnga1 PE=2 SV=2
355.0 [0..460] [998..149]

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Predicted Domain #1
Region A:
Residues: [1-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSMARFRKV NRQSEKLEPE ASASLLKSSP NILENFAYDE FQPIQTNHPL LKRMATTPVA  60
   61 QSGSQSSSSS TSSTRKAEPK FCDTLERHAF MRNVIN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [97-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQPESTRRYS TPGEKEAQVR RSLEEITKDL KEIEQFVSAT EELMQREKEQ EQMMYSNKEN  60
   61 KCPSPVKRVT YKINAYKAPP RRHRPGSPRF YHSRLYFRNG KIGCVDSTEH QNNVGATHAL 120
  121 VKHILHHEKP LVSPDSVRRV LEQDSFEMVP LPGAVPEIVP DPIAIQRAEE LAAATGQVVL 180
  181 PKEEEEEEKS SPLHQVESQP DVDEDEQDVQ 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [307-742]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ICYNESPELQ NEDRNERTQR TPSINESEIV AVDEPDTEMN SDVDHRKPSS AGSLDSQGQQ  60
   61 FLRDQVRHLV RRFTARANKV KSRIELPPTP SSSSTVSSPS PPPTKSLHPS PQHKVRLVPA 120
  121 GQSPHRGRLF EADTPRSNVW LCSSLCGANN DERTLDPQGK IYISWLCVVS LSFLYNAWVI 180
  181 PLRASFPFQT KENTNIWLAC DFCADIIYLL DVVFFKHRVM YLFEGFWVKN KNLTRKNYMR 240
  241 KLQFKLDLLA LLPLELLYFK LGTQAVWLRF PRFFKIQSFW EVFRLLDRVI SSPHFVRVAK 300
  301 TLTYMLYMIH ITAALYYAYS DYQGLGQNRW VFSGKGHPYV RCFAFATKTA TSIGKNPKPE 360
  361 RQGEYVFMTV AWLMGVFVFA LLIGQIRDII STATRNKHEY RQLEDETLEY MRRLNLSQEV 420
  421 QSRVKMWFQF TWEQQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.0
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [743-915]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLDESNILDA LPINLKTDIA ISVHIQTLSK VQLFADCEEA LLRDLVLKLR AVTFLPGDFV  60
   61 CRKGEVGREM YIVKLGQVQV MGGPSSDVVL ATLTEGSVFG EISLLGINGA DRRTADVRSK 120
  121 GYSNLFVLSK SDLNEVIAYY PTAQAILKKR ARQLMRKNAA REREEERERA RSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.522879
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic nucleotide-gated ion channel activity 10.1422916734545 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 10.1422916734545 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 9.72053268940283 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
ion channel activity 8.54258173089828 bayes_pls_golite062009
gated channel activity 8.40583491856766 bayes_pls_golite062009
channel activity 8.39905773163311 bayes_pls_golite062009
passive transmembrane transporter activity 8.39905773163311 bayes_pls_golite062009
substrate-specific channel activity 8.39470084162975 bayes_pls_golite062009
cation channel activity 8.37340171056317 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
ligand-gated channel activity 7.41584542512987 bayes_pls_golite062009
ligand-gated ion channel activity 7.41584542512987 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
metal ion transmembrane transporter activity 7.27305202954784 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
voltage-gated ion channel activity 4.92543918512794 bayes_pls_golite062009
voltage-gated channel activity 4.90247452112447 bayes_pls_golite062009
intracellular cAMP activated cation channel activity 3.95109938608832 bayes_pls_golite062009
voltage-gated cation channel activity 3.17407714154852 bayes_pls_golite062009
potassium channel activity 3.16645830461177 bayes_pls_golite062009
ion transmembrane transporter activity 2.68223244325599 bayes_pls_golite062009
cation transmembrane transporter activity 2.45301353888223 bayes_pls_golite062009
voltage-gated potassium channel activity 2.42821009576643 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.29036912617062 bayes_pls_golite062009
substrate-specific transporter activity 2.1888705807099 bayes_pls_golite062009
binding 1.39247933044015 bayes_pls_golite062009
protein binding 0.71319432010926 bayes_pls_golite062009
molecular transducer activity 0.685020633246238 bayes_pls_golite062009
signal transducer activity 0.685020633246238 bayes_pls_golite062009
enzyme regulator activity 0.362412435891451 bayes_pls_golite062009
transporter activity 0.0214385136840991 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [916-1040]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQADVVIGNP KTPETAPKLL QTVIQALPFE SPAVVLITRG SKRMRRKRQS VQMETIVEPK  60
   61 MEVTGAAETQ DQKGLKTGRC SPDLLSSIQQ ELKSKHKFIN LTDSEKALIS QSANNSLEDM 120
  121 KVVDL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle