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Protein Overview: FHLA_ECOLI

General Information:
Name(s) found: FHLA_ECOLI [Swiss-Prot]
Description(s) found:
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  • pir||S12079 transcription activator fhlA - Escherichia coli (strain K-12) [NCBI NR]
  • gi|882624|gb|AAA69241.1| transcriptional activator of the formate hydrogenlyase system [NCBI NR]
  • gi|41437|emb|CAA36476.1| unnamed protein product [Escherichia coli] [NCBI NR]
  • gi|120053|sp|P19323.1|FHLA_ECOLI RecName: Full=Formate hydrogenlyase transcriptional activator [NCBI NR]
  • Formate hydrogenlyase transcriptional activator - Escherichia coli [Swiss-Prot]
  • formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons; transcriptional activator for induction of formate hydrogen-lyase (EBP family) [Escherichia coli K12]gi|1789087|gb|AAC75773.1| formate hydrogen-lyase transcriptional activato [nrdb_11152004_Chlamydomonas]
  • Formate hydrogenlyase transcriptional activator [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • unnamed protein product [Escherichia coli] [nr-271106-contam.fasta]
  • Formate hydrogenlyase transcriptional activator OS=Escherichia coli (strain K12) GN=fhlA PE=1 SV=1 [uniprot-Ecoli-reviewed-110511.fasta]
    • Organism: Escherichia coli
    Length: 692 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYTPMSDLG QQGLFDITRT LLQQPDLASL CEALSQLVKR SALADNAAIV LWQAQTQRAS  60
   61 YYASREKDTP IKYEDETVLA HGPVRSILSR PDTLHCSYEE FCETWPQLDA GGLYPKFGHY 120
  121 CLMPLAAEGH IFGGCEFIRY DDRPWSEKEF NRLQTFTQIV SVVTEQIQSR VVNNVDYELL 180
  181 CRERDNFRIL VAITNAVLSR LDMDELVSEV AKEIHYYFDI DDISIVLRSH RKNKLNIYST 240
  241 HYLDKQHPAH EQSEVDEAGT LTERVFKSKE MLLINLHERD DLAPYERMLF DTWGNQIQTL 300
  301 CLLPLMSGDT MLGVLKLAQC EEKVFTTTNL NLLRQIAERV AIAVDNALAY QEIHRLKERL 360
  361 VDENLALTEQ LNNVDSEFGE IIGRSEAMYS VLKQVEMVAQ SDSTVLILGE TGTGKELIAR 420
  421 AIHNLSGRNN RRMVKMNCAA MPAGLLESDL FGHERGAFTG ASAQRIGRFE LADKSSLFLD 480
  481 EVGDMPLELQ PKLLRVLQEQ EFERLGSNKI IQTDVRLIAA TNRDLKKMVA DREFRSDLYY 540
  541 RLNVFPIHLP PLRERPEDIP LLAKAFTFKI ARRLGRNIDS IPAETLRTLS NMEWPGNVRE 600
  601 LENVIERAVL LTRGNVLQLS LPDIVLPEPE TPPAATVVAL EGEDEYQLIV RVLKETNGVV 660
  661 AGPKGAAQRL GLKRTTLLSR MKRLGIDKSA LI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 21.30103 3',5'-cyclic nucleotide phosphodiesterase 2A, GAF A and GAF B domains
    2 View Details [220..628] PSI-BLAST 91.39794 Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
    3 View Details [629..692] PSI-BLAST 89.69897 Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  2.80545151006505 bayes_pls_golite062009
  • DNA binding
    		•  2.12853183689157 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.06466906422115 bayes_pls_golite062009
  • transcription factor activity
    		•  2.00805912336419 bayes_pls_golite062009
  • binding
    		•  1.3234252548847 bayes_pls_golite062009
  • two-component response regulator activity
    		•  1.13458435530855 bayes_pls_golite062009
  • protein histidine kinase activity
    		•  1.10591382238785 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  1.05257897401701 bayes_pls_golite062009
  • catalytic activity
    		•  0.319188290441009 bayes_pls_golite062009
  • two-component sensor activity
    		•  0.213200223299938 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein histidine kinase activity
    		•  2.35011582062573 bayes_pls_golite062009
  • two-component sensor activity
    		•  2.32303301074957 bayes_pls_golite062009
  • phosphotransferase activity, nitrogenous group as acceptor
    		•  2.28838869071567 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.95073642969863 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.91141407779641 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.9017593265179 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.90014393273511 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  1.82370030183942 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.79922369980544 bayes_pls_golite062009
  • transporter activity
    		•  1.55572428045529 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.52217781539459 bayes_pls_golite062009
  • ATPase activity
    		•  1.48474288797022 bayes_pls_golite062009
  • two-component response regulator activity
    		•  1.45919623810582 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  1.4031990658196 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.38483976298883 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.37457738689583 bayes_pls_golite062009
  • catalytic activity
    		•  1.37148167194523 bayes_pls_golite062009
  • binding
    		•  1.30574971150356 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.24278046928678 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.2014318795788 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.19670408144267 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.17063957238561 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.16918853509059 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.16885789920943 bayes_pls_golite062009
  • hydrolase activity
    		•  1.09839981963412 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.900561861643259 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.530058973650498 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.5127850474754 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.51230334374838 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.50688037036449 bayes_pls_golite062009
  • nucleotide binding
    		•  0.49473184426584 bayes_pls_golite062009
  • DNA binding
    		•  0.460315660888175 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.32754685224555 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  0.128277449580549 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.109938795198381 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0838665746103899 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle