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Protein Overview: Cyp1-PA

General Information:
Name(s) found: Cyp1-PA / FBpp0074017 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Cyclophilin 1 is referred to in FlyBase by the symbol Dmel\Cyp1 (CG9916, FBgn0004432). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16211706..16214445. It has the cytological map location 14B9-14B12. Based on sequence similarity, it is predicted to have molecular function</span>: peptidyl-prolyl cis-trans isomerase activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 227 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    nuclear cyclin-dependent protein kinase holoenzyme complex [NAS]
    cytosol [ISS]
    positive transcription elongation factor complex b [NAS]
    Biological Process: autophagic cell death [IEP]
    salivary gland cell autophagic cell death [IEP]
    protein folding [IEA][NAS]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [IEA][ISS][NAS]
    cyclin-dependent protein kinase regulator activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSFCATLIR QFRHRSAAAF QIAESAILAN KSITLASSAC SVNRGQLQFG IQIVREYSKA  60
   61 SKMSTLPRVF FDMTADNEPL GRIVMELRSD VVPKTAENFR ALCTGEKGFG YKGSIFHRVI 120
  121 PNFMCQGGDF TNHNGTGGKS IYGNKFPDEN FELKHTGSGI LSMANAGANT NGSQFFICTV 180
  181 KTAWLDNKHV VFGEVVEGLD VVKKIESYGS QSGKTSKKII VANSGSL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..227] PSI-BLAST 73.221849 Cyclophilin (eukaryotic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.46018233647024 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.130251391659493 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle