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Protein Overview: BRCA1_RAT

General Information:
Name(s) found: BRCA1_RAT [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • Breast cancer type 1 susceptibility protein homolog OS=Rattus norvegicus GN=Brca1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1817 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [UNKNOWN][IEA]
    nucleus [UNKNOWN][IEA]
    ribonucleoprotein complex [UNKNOWN]
    cytoplasm [UNKNOWN][IEA]
    mitochondrial matrix [IDA]
    BRCA1-A complex [UNKNOWN]
    protein complex [UNKNOWN]
    BRCA1-BARD1 complex [UNKNOWN]
    intracellular [IEA]
    nucleoplasm [UNKNOWN]
    Biological Process: negative regulation of fatty acid biosynthetic process [UNKNOWN][ISS]
    positive regulation of DNA repair [UNKNOWN]
    DNA repair [TAS]
    chordate embryonic development [UNKNOWN][IEA]
    response to organic substance [IEP]
    response to estrogen stimulus [UNKNOWN][IEP]
    centrosome cycle [UNKNOWN][IEA]
    DNA replication [UNKNOWN][IEA]
    double-strand break repair via homologous recombination [UNKNOWN]
    chromosome segregation [UNKNOWN]
    response to nutrient [IEP]
    DNA damage response, signal transduction resulting in induction of apoptosis [UNKNOWN]
    dosage compensation, by inactivation of X chromosome [UNKNOWN][IEA]
    brain development [IEP]
    postreplication repair [UNKNOWN]
    cell cycle [IEA]
    double-strand break repair [UNKNOWN]
    negative regulation of transcription [UNKNOWN]
    positive regulation of protein ubiquitination [UNKNOWN]
    G2/M transition DNA damage checkpoint [UNKNOWN]
    response to lipid [IEP]
    response to ionizing radiation [UNKNOWN]
    protein ubiquitination [UNKNOWN]
    Molecular Function: ubiquitin-protein ligase activity [UNKNOWN]
    zinc ion binding [IEA]
    identical protein binding [UNKNOWN]
    RNA binding [UNKNOWN]
    protein binding [UNKNOWN][IEA]
    transcription regulator activity [IEA]
    metal ion binding [IEA]
    damaged DNA binding [UNKNOWN][TAS]
    ligase activity [IEA]
    enzyme binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLSAVRIQE VQNVLHAMQK ILECPICLEL IKEPVSTQCD HIFCKFCMLK LLNQKKGPSQ  60
   61 CPLCKNEITK RSLQGSARFS QLVEELLKII DAFELDTGMQ CANGFSFSKK KNSSSELLNE 120
  121 DASIIQSVGY RNRVKKLQQI ESGSATLKDS LSVQLSNLGI VRSMKKNRQT QPQNKSVYIA 180
  181 LESDSSEERV NAPDGCSVRD QELFQIAPGG AGDEGKLNSA KKAACDFSEG IRNIEHHQCS 240
  241 DKDLNPTENH ATERHPEKCP RISVANVHVE PCGTDARASS LQRGTRSLLF TEDRLDAEKA 300
  301 EFCDRSKQSG AAVSQQSRWA DSKETCNGRP VPRTEGKADP NVDSLCGRKQ WNHPKSLCPE 360
  361 NSGATTDVPW ITLNSSIQKV NEWFSRTGEM LTSDNASDRR PASNAEAAVV LEVSNEVDGC 420
  421 FSSSKKIDLV APDPDNAVMC TSGRDFSKPV ENIINDKIFG KTYQRKGSRP HLNHVTEIIG 480
  481 TFTTEPQIIQ EQPFTNKLKR KRSTCLHPED FIKKADLTVV QRISENLNQG TDQMEPNDQA 540
  541 MSITSNGQEN RATGNDLQRG RNAHPIESLR KEPAFTAKAK SISNSISDLE VELNVHSSKA 600
  601 PKKNRLRRKS TRCVLPLEPI SRNPSPPTCA ELQIESCGSS EETKKNNSNQ TPAGHIREPQ 660
  661 LIEDTEPAAD AKKNEPNEHI RKRSASDAFP EEKLMNKAGL LTSCSSPRKP QGPVNPSPER 720
  721 KGIEQLEMCQ MPDNNKELGD LVLGGEPSGK PTEPSEESTS VSLVPDTDYD TQNSVSILEA 780
  781 NTVRYARTGS VQCMTQFVAS ENPKELVHGS NNAGSGSECF KHPLRHELNH NQETIEMEDS 840
  841 ELDTQYLQNT FQVSKRQSFA LFSKLRSPQK DCTLVGARSV PSREPSPKVT SRGEQKERQG 900
  901 QEESEISHVQ AVTVTVGLPV PCQEGKPGAV TMCADVSRLC PSSHYRSCEN GLNTTDKSGI 960
  961 SQNSHFRQSV SPLRSSIKTD NRKTLTEGRF EKHTERGMGN ETAVQSTIHT ISLNNRGDAC1020
 1021 LEASSGSVIE VHSTGENVQG QLDRNRGPKV NTVSLLDSTQ PGVSKQSAPV SDKYLEIKQE1080
 1081 SKAVSADFSP CLFSDHLEKP MRSDKTFQVC SETPDDLLDD VEIQENASFG EGGITEKSAI1140
 1141 FNGSVLRRES SRSPSPVTHA SKSRSLHRGS RKLEFSEESD STEDEDLPCF QHLLSRVSST1200
 1201 PELTRCSSVV TQRVPEKAKG TQAPRKSSIS DCNNEVILGE ASQEYQFSED AKCSGSMFSS1260
 1261 QHSAALGSPA NALSQDPDFN PPSKQRRHQA ENEEAFLSDK ELISDHEDMA ACLEEASDQE1320
 1321 EDSIIPDSVA SGYESEANLS EDCSQSDILT TQQRATMKDN LIKLQQEMAQ LEAVLEQHGS1380
 1381 QPSGHPPCLP ADPCALEDLP DPEQNRSGTA ILTSKNINEN PVSQNPKRAC DDKSQPQPPD1440
 1441 GLPSGDKESG MRRPSPFKSP LTSSRCSARG HSRSLQNRNS TSQEELLQPA XLEKSCEPHN1500
 1501 LTGRSCLPRQ DLEGTPYPES GIRLVSSRDP DSESPKVSAL VCTAPASTSA LKISQGQVAG1560
 1561 SCRSPAAGGA DTAVVEIVSK IKPEVTSPKE RAERDISMVV SGLTPKEVMI VQKFAEKYRL1620
 1621 ALTDVITEET THVIIKTDAE FVCERTLKYF LGIAGGKWIV SYSWVIKSIQ ERKLLSVHEF1680
 1681 EVKGDVVTGS NHQGPRRSRE SQEKLFEGLQ IYCCEPFTNM PKDELERMLQ LCGASVVKEL1740
 1741 PLLTRDTGAH PIVLVQPSAW TEDNDCPDIG QLCKGRLVMW DWVLDSISVY RCRDLDAYLV1800
 1801 QNITCGRDGS EPQDSND

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle