YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA. A cascade of processes induced by the detection of DNA damage within a cell. The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. Any cell cycle checkpoint that blocks entry into M phase. A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage. The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure. A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: G2/M transition DNA damage checkpoint
Acc: GO:0031572
Aspect: Biological Process
Desc: A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage.
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 28 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031572 - G2/M transition DNA damage checkpoint (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle