Protein Overview: FAT1

General Information:
Name(s) found:	FAT1 / YBR041W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|51704276\|sp\|P38225.2\|FAT1_YEAST RecName: Full=Very long-chain fatty acid transport protein [NCBI NR] gi\|41629676\|ref\|NP_009597.2\| Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids; Fat1p [Saccharomyces cerevisiae] [NCBI NR] gi\|3152696\|gb\|AAC17118.1\| very long-chain fatty acyl-CoA synthetase [Saccharomyces cerevisiae] [NCBI NR] Very long-chain fatty acid transport protein OS=Saccharomyces cerevisiae GN=FAT1 PE=1 SV=2 [Swiss-Prot] FAT1 Very long-chain fatty acyl-CoA synthetase [mips] Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids [SGD] FAT1 SGDID:S0000245, Chr II from 318228-320237, Verified ORF [yeastflysequest.fasta] FAT1 SGDID:S0000245, Chr II from 318266-320275, Verified ORF [10112005cervSGD.fasta] Fat1p [Saccharomyces cerevisiae]gi\|3152696\|gb\|AAC17118.1\| very long-chain fatty acyl-CoA synthetase [Saccharomyces cerevisiae]gi\|51704276\|sp\|P38225\|FAT1_YEAST Very long-chain fatty acid transport protein [nrdb_11152004_Chlamydomonas] (P38225) Very long-chain fatty acid transport protein [cerv4932.FASTAC] FAT1 SGDID:S000000245, Chr II from 318266-320275, Verified ORF, "Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Very long-chain fatty acid transport protein [nr-271106-contam.fasta] very long-chain fatty acyl-CoA synthetase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids; Fat1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Very long-chain fatty acid transport protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FAT1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] FAT1 SGDID:S000000245, Chr II from 318266-320275, Genome Release 64-1-1, Verified ORF, "Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids" [yeast-030211-contam.fasta] FAT1 SGDID:S000000245, Chr II from 318266-320275, Genome Release 64-2-1, Verified ORF, "Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids" [20141208_orf_trans.fasta] YBR041W SGDID:S000000245, Chr II from 318266-320275, Genome Release 64-1-1, Verified ORF, "Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	669 amino acids
Gene Ontology:
Cellular Component:	lipid particle [IDA] peroxisome [IDA] microsome [IDA] plasma membrane [IMP][ISS]
Biological Process:	lipid transport [IMP][ISS] very long-chain fatty acid metabolic process [IMP]
Molecular Function:	long-chain fatty acid-CoA ligase activity [IMP][ISS] long-chain fatty acid transporter activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY KEDWYIIPYF  60
   61 LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP MAEKGEFQLE TFTYIETYNI 120
  121 VLRLSHILHF DYNVQAGDYV AIDCTNKPLF VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL 180
  181 KISNITQVFI DPDASNPIRE SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV 240
  241 RTPLGLTDFK PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF 300
  301 HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR YLLHTPISKY 360
  361 EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA PFATTTFQKG DFGIGACRNY 420
  421 GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK GFCEVAPVGE PGEMLMRIFF PKKPETSFQG 480
  481 YLGNAKETKS KVVRDVFRRG DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV 540
  541 EDQLTASNKE QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP 600
  601 SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR YEVLTAADWE 660
  661 AIDAQTIKL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		CDC50 CSR1 DNF1 FAA1 FAA2 FAA4 FAT1 PDR16

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ARG1	FAT1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	FAT1	Huh WK, et al. (2003)
View Data	FAT1 and ERG6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..669]	PSI-BLAST	118.0	Acetyl-CoA synthetase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.25

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2