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Protein Overview: HDAC4_RAT

General Information:
Name(s) found: HDAC4_RAT [Swiss-Prot]
Description(s) found:
Found 4 descriptions.
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  • Histone deacetylase 4 OS=Rattus norvegicus GN=Hdac4 PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1077 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    Z disc [IDA]
    cytoplasm [UNKNOWN][IDA]
    transcriptional repressor complex [UNKNOWN][IEA]
    histone deacetylase complex [UNKNOWN][IEA]
    cytosol [UNKNOWN][IEA]
    neuromuscular junction [UNKNOWN][IEA]
    A band [IDA]
    actomyosin [UNKNOWN][IEA]
    sarcomere [IDA]
    Biological Process: negative regulation of cell proliferation [UNKNOWN][IEA]
    positive regulation of cell proliferation [UNKNOWN][IEA]
    negative regulation of glycolysis [IEA]
    regulation of transcription [IEA]
    positive regulation of transcription factor activity [UNKNOWN][IEA]
    negative regulation of osteoblast differentiation [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    chromatin remodeling [UNKNOWN][IEA]
    skeletal system development [UNKNOWN][IEA]
    negative regulation of transcription, DNA-dependent [UNKNOWN]
    regulation of skeletal muscle fiber development [UNKNOWN][IEA]
    regulation of protein binding [UNKNOWN][IEA]
    positive regulation of protein sumoylation [UNKNOWN][IEA]
    peptidyl-lysine deacetylation [UNKNOWN][IEA]
    negative regulation of myotube differentiation [UNKNOWN][IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    histone deacetylation [UNKNOWN][IEA]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    response to denervation involved in regulation of muscle adaptation [IEA]
    negative regulation of transcription factor activity [UNKNOWN][IEA]
    osteoblast development [UNKNOWN][IEA]
    response to drug [IDA]
    regulation of striated muscle cell differentiation [UNKNOWN]
    response to interleukin-1 [UNKNOWN][IEA]
    regulation of cardiac muscle contraction by calcium ion signaling [UNKNOWN][IEA]
    Molecular Function: zinc ion binding [UNKNOWN][IEA]
    histone deacetylase binding [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN]
    transcription factor binding [UNKNOWN][IEA]
    molecular_function [ND]
    DNA binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    potassium ion binding [UNKNOWN][IEA]
    transcription repressor binding [UNKNOWN][IEA]
    histone deacetylase activity [UNKNOWN][IEA]
    transcription corepressor activity [UNKNOWN][IEA]
    promoter binding [UNKNOWN][IEA]
    transcription activator activity [IEA]
    transcription repressor activity [UNKNOWN]
    protein deacetylase activity [UNKNOWN]
    transcription activator binding [UNKNOWN][IEA]
    specific transcriptional repressor activity [UNKNOWN][IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPAAVPMD LRLDHQFSLP  60
   61 LEPALREQQL QQELLALKQK QQIQRQILIA EFQRQHEQLS RQHEAQLHEH IKQQQEMLAM 120
  121 KHQQELLEHQ RKLERHRQEQ ELEKQHREQK LQQLKNKEKG KESAVASTEV KMKLQEFVLN 180
  181 KKKALAHRNL NHCMSSDPRY WYGKTQHSSL DQSSPPQSGV SASYNHPVLG MYDAKDDFPL 240
  241 RKTASEPNLK LRSRLKQKVA ERRSSPLLRR KDGPVATALK KRPLDVTDSA CSSAPGSGPS 300
  301 SPNSSSGNVS TENGIAPTVP STPAETSLAH RLVTREGSVA PLPLYTSPSL PNITLGLPAT 360
  361 GPAAGAAGQQ DAERLALPAL QQRISLFPGT HLTPYLSTSP LERDGGAAHN PLLQHMVLLE 420
  421 QPPTQTPLVT GLGALPLHTQ SLVGADRVSP SIHKLRQHRP LGRTQSAPLP QNAQALQHLV 480
  481 IQQQHQQFLE KHKQQFQQQQ LHLSKMISKP SEPPRQPESH PEETEEELRE HQALLDEPYL 540
  541 DRLPGQKEPS LAGVQVKQEP IESEEEEVEA TREAEPSQRP ATEQELLFRQ QALLLEQQRI 600
  601 HQLRNYQASM EAAGIPVSFG SHRPLSRAQS SPASATFPMS VQEPPTKPRF TTGLVYDTLM 660
  661 LKHQCTCGNT NSHPEHAGRI QSIWSRLQET GLRGKCECIR GRKATLEELQ TVHSEAHTLL 720
  721 YGTNPLNRQK LDSSLTSVFV RLPCGGVGVD SDTIWNEVHS SGAARLAVGC VVELVFKVAT 780
  781 GELKNGFAVV RPPGHHAEES TPMGFCYFNS VAIAAKLLQQ RLNVSKILIV DWDVHHGNGT 840
  841 QQAFYNDPNV LYMSLHRYDD GNFFPGSGAP DEVGTGPGVG FNVNMAFTGG LDPPMGDAEY 900
  901 LAAFRTVVMP IANEFAPDVV LVSSGFDAVE GHPTPLGGYN LSAKCFGYLT KQLMGLAGGR 960
  961 IVLALEGGHD LTAICDASEA CVSALLGNEL EPLPEKVLHQ RPNANAVHSM EKVMGIHSEY1020
 1021 WRCLQRLSPT VGHSLIEAQK CENEEAETVT AMASLSVGVK PAEKRSEEEP MEEEPPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle