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Protein Overview: M2K2_ARATH

General Information:
Name(s) found: M2K2_ARATH [Swiss-Prot]
Description(s) found:
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  • pir||T08542 mitogen-activated protein kinase kinase (EC 2.7.1.-) 2 [similarity] - Arabidopsis thaliana [NCBI NR]
  • gi|7269880|emb|CAB79739.1| MAP kinase kinase 2 [Arabidopsis thaliana] [NCBI NR]
  • gi|4914405|emb|CAB43656.1| MAP kinase kinase 2 [Arabidopsis thaliana] [NCBI NR]
  • gi|3219267|dbj|BAA28828.1| MAP kinase kinase 2 [Arabidopsis thaliana] [NCBI NR]
  • gi|18700200|gb|AAL77710.1| AT4g29810/F27B13_50 [Arabidopsis thaliana] [NCBI NR]
  • gi|15233715|ref|NP_194710.1| ATMKK2 (ARABIDOPSIS THALIANA MAP KINASE KINASE 2); MAP kinase kinase/ kinase [Arabidopsis thaliana] [NCBI NR]
  • gi|14326471|gb|AAK60281.1|AF385688_1 AT4g29810/F27B13_50 [Arabidopsis thaliana] [NCBI NR]
  • gi|110279039|sp|Q9S7U9.2|M2K2_ARATH RecName: Full=Mitogen-activated protein kinase kinase 2; Short=MAP kinase kinase 2; Short=AtMKK2; Short=AtMAP2Kbeta [NCBI NR]
  • Mitogen-activated protein kinase kinase 2 OS=Arabidopsis thaliana GN=MKK2 PE=1 SV=2 [Swiss-Prot]
  • (O80395) MAP kinase kinase 2 (AT4g29810/F27B13_50) [athaliana3702.FASTAC.txt]
  • MAP kinase kinase 2 [Arabidopsis thaliana]gi|4914405|emb|CAB43656.1| MAP kinase kinase 2 [Arabidopsis thaliana]gi|7269880|emb|CAB79739.1| MAP kinase kinase 2 [Arabidopsis thaliana]gi|18700200|gb|AAL77710.1| AT4g29810/F27B13_50 [Arabidopsis thaliana]gi [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Mitogen-activated protein kinase kinase (MAPKK) (MKK2) [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: MKK2, MK1, ATMKK2 | ATMKK2 (MAP KINASE KINASE 2); MAP kinase kinase/ kinase | chr4:14593305-14595247 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • AT4g29810/F27B13_50 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • MAP kinase kinase 2 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • ATMKK2 (MAP KINASE KINASE 2); MAP kinase kinase/ kinase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (AtMKK2) (AtMAP2Kbeta) [nr-271106-contam.fasta]
  • | Symbols: ATMKK2, MKK2, MK1 | MAP kinase kinase 2 | chr4:14593299-14595241 REVERSE LENGTH=363 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 363 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    plasma membrane [IDA]
    Biological Process: MAPKKK cascade [IC][IGI]
    response to cold [IDA][IMP]
    defense response, incompatible interaction [IGI]
    response to salt stress [IDA][IGI][IMP]
    cold acclimation [IMP]
    Molecular Function: MAP kinase kinase activity [IDA][ISS][TAS]
    kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKGGFSNNL KLAIPVAGEQ SITKFLTQSG TFKDGDLRVN KDGVRIISQL EPEVLSPIKP  60
   61 ADDQLSLSDL DMVKVIGKGS SGVVQLVQHK WTGQFFALKV IQLNIDEAIR KAIAQELKIN 120
  121 QSSQCPNLVT SYQSFYDNGA ISLILEYMDG GSLADFLKSV KAIPDSYLSA IFRQVLQGLI 180
  181 YLHHDRHIIH RDLKPSNLLI NHRGEVKITD FGVSTVMTNT AGLANTFVGT YNYMSPERIV 240
  241 GNKYGNKSDI WSLGLVVLEC ATGKFPYAPP NQEETWTSVF ELMEAIVDQP PPALPSGNFS 300
  301 PELSSFISTC LQKDPNSRSS AKELMEHPFL NKYDYSGINL ASYFTDAGSP LATLGNLSGT 360
  361 FSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..363] PSI-BLAST 49.69897 X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.19908793854422 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.14496167267281 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.748533008006377 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • protein complex binding
    		•  0.132247221889251 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • tubulin binding
    		•  0.0510156114567444 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle