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Protein Overview: MCM3_ARATH

General Information:
Name(s) found: MCM3_ARATH [Swiss-Prot]
Description(s) found:
Found 13 descriptions.
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  • DNA replication licensing factor MCM3 OS=Arabidopsis thaliana GN=MCM3 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 776 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA replication initiation [ISS]
    DNA unwinding involved in replication [TAS]
    Molecular Function: nucleotide binding [IEA]
    DNA binding [IEA][ISS]
    ATP binding [IEA][ISS]
    DNA-dependent ATPase activity [ISS]
    nucleoside-triphosphatase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVPEETRLR HKRDFIQFLD SMYMEEIKAL VHQKRHRLII NISDIHHHFR EVASRILKNP  60
   61 NEYMQSFCDA ATEATRAIDP KYLKEGELVL VGFEGYFVSR VVTPRELLSD FIGSMVCVEG 120
  121 IVTKCSLVRP KVVKSVHFCP STGEFTNRDY RDITSHAGLP TGSVYPTRDD KGNLLVTEYG 180
  181 LCKYKDHQTL SIQEVPENAA PGQLPRSVDV IAEDDLVDSC KPGDRVSVFG IYKALPGKSK 240
  241 GSVNGVFRTI LIANNIALLN KEANAPIYTK QDLDNIKNIA RRDDAFDLLA RSLAPSIYGH 300
  301 AWIKKAVVLL MLGGVEKNLK NGTHLRGDIN MMMVGDPSVA KSQLLRAIMN IAPLAISTTG 360
  361 RGSSGVGLTA AVTSDQETGE RRLEAGAMVL ADKGIVCIDE FDKMNDQDRV AIHEVMEQQT 420
  421 VTIAKAGIHA SLNARCSVVA AANPIYGTYD RSLTPTKNIG LPDSLLSRFD LLFIVLDQMD 480
  481 AGIDSMISEH VLRMHRYKND RGEAGPDGSL PYAREDNAES EMFVKYNQTL HGKKKRGQTH 540
  541 DKTLTIKFLK KYIHYAKHRI TPKLTDEASE RIAEAYADLR NAGSDTKTGG TLPITARTLE 600
  601 TIIRLATAHA KMKLSSEVTK ADAEAALKLM NFAIYHQELT EMDDREQEER QREQAEQERT 660
  661 PSGRRGNQRR NNEDGAENDT ANVDSETADP MEVDEPSVEQ FSGTVSAARI ETFERVFGQH 720
  721 MRTHRLDDIS IADIETVVNN NGVGASRYSA DEIMALLEKL QDDNKVMISD GKVHII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..293] PSI-BLAST 45.045757 DNA replication initiator (cdc21/cdc54) N-terminal domain
    2 View Details [294..776] PSI-BLAST 75.69897 No description for 2dhrA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  4.29626483284963 bayes_pls_golite062009
  • DNA binding
    		•  3.71771169141041 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.48139490984491 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.43027351695641 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  2.77979101622935 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.51555240517937 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  2.42617682290608 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.13063800565247 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10110937001387 bayes_pls_golite062009
  • structural molecule activity
    		•  1.9177190829469 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.84819558112187 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.12203697857261 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.85691075793641 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.638831894247026 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.635129001787169 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.325774164899685 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.31769813397725 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.314881439089948 bayes_pls_golite062009
  • translation regulator activity
    		•  0.31332179848255 bayes_pls_golite062009
  • exonuclease activity
    		•  0.28313884527829 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.263197317040851 bayes_pls_golite062009
  • transferase activity
    		•  0.249054945579328 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.2080607201312 bayes_pls_golite062009
  • RNA binding
    		•  0.18502033889261 bayes_pls_golite062009
  • protein binding
    		•  0.152645195799531 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.125256208482441 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.109774918833391 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.0954216620147701 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.0179535526984695 bayes_pls_golite062009
  • helicase activity
    		•  0.0121541775159524 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle