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Protein Overview: P2C70_ARATH

General Information:
Name(s) found: P2C70_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|2507222|sp|P46014.2|P2C70_ARATH RecName: Full=Protein phosphatase 2C 70; Short=AtPP2C70; AltName: Full=Kinase-associated protein phosphatase [NCBI NR]
  • gi|21436053|gb|AAM51227.1| putative kinase associated protein phosphatase [Arabidopsis thaliana] [NCBI NR]
  • gi|1709236|gb|AAB38148.1| kinase associated protein phosphatase [NCBI NR]
  • gi|15239690|ref|NP_197429.1| KAPP (KINASE ASSOCIATED PROTEIN PHOSPHATASE); phosphoprotein phosphatase/ protein kinase binding / protein serine/threonine phosphatase [Arabidopsis thaliana] [NCBI NR]
  • gi|15027993|gb|AAK76527.1| putative kinase associated protein phosphatase [Arabidopsis thaliana] [NCBI NR]
  • Protein phosphatase 2C 70 OS=Arabidopsis thaliana GN=KAPP PE=1 SV=2 [Swiss-Prot]
  • Kinase-associated protein phosphatase OS=Arabidopsis thaliana GN=KAPP PE=1 SV=2 [Swiss-Prot]
  • (P46014) Kinase associated protein phosphatase (EC 3.1.3.16) [athaliana3702.FASTAC.txt]
  • putative kinase associated protein phosphatase [Arabidopsis thaliana]gi|15027993|gb|AAK76527.1| putative kinase associated protein phosphatase [Arabidopsis thaliana]gi|1709236|gb|AAB38148.1| kinase associated protein phosphatasegi|15239690|ref|NP_19742 [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Kinase associated protein phosphatase [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: RAG1, KAPP | KAPP (Kinase-associated protein phosphatase); protein serine/threonine phosphatase | chr5:6488452-6493184 FORWARD [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • putative kinase associated protein phosphatase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • kinase associated protein phosphatase [nr-271106-contam.fasta]
  • Kinase-associated protein phosphatase [nr-271106-contam.fasta]
  • KAPP; protein phosphatase type 2C [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: KAPP, RAG1 | kinase associated protein phosphatase | chr5:6488450-6493182 FORWARD LENGTH=581 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    Biological Process: signal transduction [IDA]
    regulation of meristem structural organization [IMP]
    Molecular Function: protein serine/threonine phosphatase activity [ISS]
    protein kinase binding [IPI]
    phosphoprotein phosphatase activity [IDA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMIGMNIIG LFMVLMLLLI SLIILFACKP WRYFSRFRSS SRFSSTFKVG DLQRPLISDD  60
   61 GNLIQGQTSE VTREYDLEGA CYQNDGLLHS SLTEGRFYKQ RLPSSSPHFS QGESFVLEVI 120
  121 SEPSDNALVG QTLKLPAEKG SLAEVQTYDW QNNRNENLQY NLEKDRLINL SPRLVEDQRS 180
  181 WLFLEVIAGP AIGLQHAVNS TSSSKLPVKL GRVSPSDLAL KDSEVSGKHA QITWNSTKFK 240
  241 WELVDMGSLN GTLVNSHSIS HPDLGSRKWG NPVELASDDI ITLGTTTKVY VRISSQNEFQ 300
  301 IPFKIGVASD PMAMRRGGRK LPMEDVCHYK WPLPGANKFG LFCVCDGHGG SGAAQSAIKI 360
  361 IPEVLANILS DSLRKEKVLS KRDASDVLRD MFAKTEARLE EHQYEGCTAT VLLVWKDNEE 420
  421 NFFAQCANLG DSACVIHLGG RYIQMTEDHR VVSLSERKRF QEAGLALRDG ETRLFGINLA 480
  481 RMLGDKFPKQ QDSRFSAEPY ISEPLRIDQS SKDVFAVLAS DGLWDVVSPK KAVQLVLQMR 540
  541 DKERGRESSA EKIANGLLNE ARAMRTKDNT SIIYLDFDTS L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] MSA 4.138997 View MSA. No confident structure predictions are available.
    2 View Details [151..300] PSI-BLAST 11.09691 NMR structure of kinase-interacting FHA domain of kinase associated protein phosphatase, KAPP in Arabidopsis
    3 View Details [301..581] PSI-BLAST 66.69897 CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.56127102364169 bayes_pls_golite062009
  • DNA binding
    		•  2.54997876495241 bayes_pls_golite062009
  • protein binding
    		•  2.39508335485646 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.22571769605285 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11320148026734 bayes_pls_golite062009
  • phosphatase activity
    		•  2.086756740043 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.03230917699612 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.01486767944645 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.99648305813116 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.93563385936087 bayes_pls_golite062009
  • hydrolase activity
    		•  1.88990919434676 bayes_pls_golite062009
  • ligase activity
    		•  1.64151662949063 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.45971669654811 bayes_pls_golite062009
  • SMAD binding
    		•  1.43534842779486 bayes_pls_golite062009
  • transcription factor activity
    		•  1.4323861652511 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.2195228488096 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20850094286943 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  1.18788393207503 bayes_pls_golite062009
  • R-SMAD binding
    		•  1.14324880762906 bayes_pls_golite062009
  • histone binding
    		•  1.01074250987871 bayes_pls_golite062009
  • protein kinase activity
    		•  0.956391533542429 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.93464013260959 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • signal transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.702922491069451 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.69092487545226 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.67835173780149 bayes_pls_golite062009
  • kinase activity
    		•  0.657412349276901 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.648647048549737 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.641170666751583 bayes_pls_golite062009
  • transcription factor binding
    		•  0.60299244480433 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  0.59893320281242 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.59302206566387 bayes_pls_golite062009
  • co-SMAD binding
    		•  0.496889433084648 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.495611591196503 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.450721599587006 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.450721599587006 bayes_pls_golite062009
  • RNA binding
    		•  0.403713641965787 bayes_pls_golite062009
  • enzyme binding
    		•  0.34998623523914 bayes_pls_golite062009
  • receptor binding
    		•  0.335261576381845 bayes_pls_golite062009
  • chromatin binding
    		•  0.32553632252601 bayes_pls_golite062009
  • identical protein binding
    		•  0.308066041448081 bayes_pls_golite062009
  • promoter binding
    		•  0.27279056014369 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.258765906761634 bayes_pls_golite062009
  • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
    		•  0.253123566271425 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.29765002420868 bayes_pls_golite062009
  • phosphatase activity
    		•  6.46633224572308 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.25564034681743 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  5.66354576593165 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.62997267604309 bayes_pls_golite062009
  • hydrolase activity
    		•  4.10826723952347 bayes_pls_golite062009
  • binding
    		•  1.74689317666387 bayes_pls_golite062009
  • catalytic activity
    		•  1.53401212718168 bayes_pls_golite062009
  • protein binding
    		•  0.425331902048676 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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