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Protein Overview: nhr-115

General Information:
Name(s) found: nhr-115 / CE35785 [WormBase]
Description(s) found:
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  • WBGene00003705 locus:nhr-115 Nuclear hormone receptor family member nhr-115 status:Confirmed UniProt:O16662 protein_id:CCD74245.1 [WormBase]
  • gi|72000740|ref|NP_503629.2| Nuclear Hormone Receptor family member (nhr-115) [Caenorhabditis elegans] [NCBI NR]
  • gi|45477009|sp|O16662.3|NH115_CAEEL RecName: Full=Nuclear hormone receptor family member nhr-115 [NCBI NR]
  • gi|37515207|gb|AAF02171.2|AF016675_3 Nuclear hormone receptor family protein 115, isoform a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|28396085|gb|AAO39204.1| nuclear receptor NHR-115 [Caenorhabditis elegans] [NCBI NR]
  • Nuclear hormone receptor family member nhr-115 OS=Caenorhabditis elegans GN=nhr-115 PE=2 SV=3 [Swiss-Prot]
  • (O16662) Nuclear hormone receptor family member nhr-115 [Swiss-Prot]
  • [wormpep111.fasta]
  • Nuclear hormone receptor family protein 115 [Caenorhabditis elegans]gi|28396085|gb|AAO39204.1| nuclear receptor NHR-115 [Caenorhabditis elegans]gi|45477009|sp|O16662|N115_CAEEL Nuclear hormone receptor family member nhr-115 [nrdb_11152004_Chlamydomonas]
  • CE35785 WBGene00003705 locus:nhr-115 zinc finger protein status:Confirmed SW:O16662 protein_id:AAF02171.2 [wormpep150.fasta]
  • 35785 WBGene00003705 locus:nhr-115 zinc finger protein status:Confirmed SW:O16662 protein_id:AAF02171.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • locus:nhr-115 zinc finger protein status:Confirmed TN:AAF02171 protein_id:AAF02171.2 [wormpep115.fasta.reversed]
  • CE35785 WBGene00003705 locus:nhr-115 zinc finger protein status:Confirmed UniProt:O16662 protein_id:AAF02171.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE35785 WBGene00003705 locus:nhr-115 zinc finger protein status:Confirmed UniProt:O16662 protein_id:AAF02171.2| [wormORF-contam.fasta]
  • Nuclear hormone receptor family member nhr-115 [nr-271106-contam.fasta]
  • Nuclear Hormone Receptor family member (nhr-115) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • nuclear receptor NHR-115 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Nuclear hormone receptor family protein 115 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE35785 WBGene00003705 locus:nhr-115 zinc finger protein status:Confirmed UniProt:O16662 protein_id:CCD74245.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE35785 WBGene00003705 locus:nhr-115 status:Confirmed UniProt:O16662 protein_id:CCD74245.1 Nuclear hormone receptor family member nhr-115 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 391 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKVLFPCQI CGQNSHGTHF GIVSCRACAA FFRRSVNSKW ARKGCLTNFK DKGSCFCKPC  60
   61 RLRKCVEIGM DASKFQYDRD AISAIKHPKI FPSVSYYVGR PEFLMFSDSN VTSQKTFIDV 120
  121 QNLVFEVSRY LDHGCETPIY AENQLKKLTL GFKLMQFDYQ NVKFFDKIGK AEFIDIIEYY 180
  181 FLTVAKWIAH FDEFRKLDQS LQIKLLQAIW HVWSKIHKCA STAFYRKSNP NAKPTQKILR 240
  241 NVCMDRMHVH KLDTSWMSDY PTEHVTRFML THHVYDFKIV ESLLKLDPTD VELTFMFAQL 300
  301 CFEYAGKRFQ GEILKITDHF QQVLSNDLHH YYITDQRRER YFQRLTDLMK VNNLIQRSIW 360
  361 ETRPHRELGR VFEISKLEFS HPEMFDDSGF C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 16.69897 No description for 2hanB was found.
    2 View Details [87..391] PSI-BLAST 34.0 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • receptor activity
    		•  3.23961300660788 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.55186574506963 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.3211572231948 bayes_pls_golite062009
  • signal transducer activity
    		•  2.3211572231948 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.91348392022358 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • hormone receptor binding
    		•  1.8288193687002 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  1.72196998170947 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • androgen receptor binding
    		•  1.48596869620742 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  1.28090460550476 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.525229083081488 bayes_pls_golite062009
  • structural molecule activity
    		•  0.281585397269403 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2
    Term Confidence Notes
  • receptor activity
    		•  5.63850766931612 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  4.81441024181511 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.63434910389609 bayes_pls_golite062009
  • signal transducer activity
    		•  4.63434910389609 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.91470119037087 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.79647267365529 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription activator binding
    		•  2.98235973123409 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.27959329058894 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.79803787243894 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • estrogen response element binding
    		•  1.56094639526803 bayes_pls_golite062009
  • estrogen receptor activity
    		•  1.47290778095383 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  1.35110271601538 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • promoter binding
    		•  1.28787959668198 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.06874057850256 bayes_pls_golite062009
  • receptor binding
    		•  1.04943671621651 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.754240851368212 bayes_pls_golite062009
  • lipid binding
    		•  0.74826259948949 bayes_pls_golite062009
  • hormone binding
    		•  0.70374209842132 bayes_pls_golite062009
  • retinoic acid binding
    		•  0.676688935879073 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.47826452126899 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.42652610679613 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle