Protein Overview: gab-1

General Information:
Name(s) found:	gab-1 / CE33742 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00001512 locus:gab-1 Gamma-aminobutyric acid receptor subunit beta status:Confirmed UniProt:O18276 protein_id:CAB07719.3 [WormBase] gi\|74958176\|sp\|O18276.3\|GBRB_CAEEL RecName: Full=Gamma-aminobutyric acid receptor subunit beta; AltName: Full=GABA(A) receptor subunit beta; Flags: Precursor [NCBI NR] gi\|71996759\|ref\|NP_499661.2\| GABa receptor subunit family member (gab-1) [Caenorhabditis elegans] [NCBI NR] gi\|29603354\|emb\|CAB07719.3\| C. elegans protein ZC482.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] Gamma-aminobutyric acid receptor subunit beta OS=Caenorhabditis elegans GN=gab-1 PE=2 SV=3 [Swiss-Prot] [wormpep104.fasta] Hypothetical protein ZC482.1 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas] CE33742 WBGene00001512 locus:gab-1 GABA receptor status:Confirmed TR:O18276 protein_id:CAB07719.3 [wormpep150.fasta] 33742 WBGene00001512 locus:gab-1 GABA receptor status:Confirmed TR:O18276 protein_id:CAB07719.3 [wormpep130-phg-ecoli-orf-rand.fasta] locus:gab-1 GABA receptor status:Confirmed TR:O18276 protein_id:CAB07719.3 [wormpep115.fasta.reversed] CE33742 WBGene00001512 locus:gab-1 GABA receptor status:Confirmed UniProt:O18276 protein_id:CAB07719.3 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE33742 WBGene00001512 locus:gab-1 GABA receptor status:Confirmed UniProt:O18276 protein_id:CAB07719.3\| [wormORF-contam.fasta] Gamma-aminobutyric-acid receptor subunit beta precursor (GABA(A) receptor subunit beta) [nr-271106-contam.fasta] GABa receptor subunit family member (gab-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] CE33742 WBGene00001512 locus:gab-1 GABA receptor status:Confirmed SW:O18276 protein_id:CAB07719.3 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE33742 WBGene00001512 locus:gab-1 status:Confirmed UniProt:O18276 protein_id:CAB07719.3 Gamma-aminobutyric acid receptor subunit beta [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	550 amino acids
Gene Ontology:
Cellular Component:	postsynaptic membrane [IEA] membrane [IEA] integral to membrane [IEA] synapse [IC]
Biological Process:	ion transport [IDA][IEA] synaptic transmission [ISS] transport [IEA]
Molecular Function:	GABA-A receptor activity [IDA] neurotransmitter receptor activity [IEA] extracellular ligand-gated ion channel activity [IDA][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRSKTRRIF HVSITLLLVS TIFCQNGTKP HNNSTSDQMS SSWSNRSQTM YSNASSLLSD  60
   61 LLLDYDIRLR PGFGGDALLL TMDIIIASFD SISEVDMDYT LTMYLHQYWT DERLRWSNEI 120
  121 PIDEMTLSGE FSQNIWVPDT FLANDKHSYL HEVTERNKML RINVDGKVAY GMRLTSTLSC 180
  181 SMNLRNFPLD SQNCTVEIES YGYTTSEVLM KWNYPLAVHG VEQADVPQFT ITGFHTEDSI 240
  241 VSTATGSYQR LSLVFQLRRS VGYFIFQTYL PCVLIVMLSW VSFWINHEAT SARVALGITT 300
  301 VLTMTTISTG VRQSLPRISY VKSIDIYLVM CFVFVFAALL EYAAVNYSYW GRERGKGGGG 360
  361 NEWPVNGANK EDRESAVNVQ KWVPSGLMDG VPQPQDRRVE ALEEAMSTSN TAAQNNNFES 420
  421 TSKPKKRSSS PIPPLCRAGN TISEESESPD YPRYSTTSLK GARPHASLNH KTHHLKGRSS 480
  481 ARAKRRMTLA RMNVSMKQSI SGIGRRARKV IPTIRVRDVN LIDKYSRVVF PVCFIVFNLF 540
  541 YWSYYMMVPS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
nicotinic acetylcholine-activated cation-selective channel activity	8.81308536112942	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	7.54118453174502	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	7.54118453174502	bayes_pls_golite062009
ion transmembrane transporter activity	7.22265353460749	bayes_pls_golite062009
passive transmembrane transporter activity	7.15153709132033	bayes_pls_golite062009
channel activity	7.15153709132033	bayes_pls_golite062009
ion channel activity	7.1489450300492	bayes_pls_golite062009
gated channel activity	7.07040350691167	bayes_pls_golite062009
metal ion transmembrane transporter activity	7.06843378380114	bayes_pls_golite062009
cation channel activity	7.05528966701307	bayes_pls_golite062009
substrate-specific channel activity	7.02602175506525	bayes_pls_golite062009
acetylcholine binding	6.82207267193568	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	6.7875346065164	bayes_pls_golite062009
cation transmembrane transporter activity	6.75385972663331	bayes_pls_golite062009
acetylcholine receptor activity	6.5970757722697	bayes_pls_golite062009
ligand-gated ion channel activity	6.32442846604167	bayes_pls_golite062009
ligand-gated channel activity	6.32442846604167	bayes_pls_golite062009
neurotransmitter binding	6.11782125343012	bayes_pls_golite062009
neurotransmitter receptor activity	5.97698567435878	bayes_pls_golite062009
amine binding	5.5479469647168	bayes_pls_golite062009
transmembrane receptor activity	5.4080353535498	bayes_pls_golite062009
receptor activity	5.11329651194787	bayes_pls_golite062009
transporter activity	5.11262082564788	bayes_pls_golite062009
transmembrane transporter activity	5.03439798256257	bayes_pls_golite062009
substrate-specific transporter activity	4.91314874981447	bayes_pls_golite062009
molecular transducer activity	4.12549692767753	bayes_pls_golite062009
signal transducer activity	4.12549692767753	bayes_pls_golite062009
G-protein coupled receptor activity	3.09231388867595	bayes_pls_golite062009
chloride channel regulator activity	2.86219582948074	bayes_pls_golite062009
binding	2.4916526322278	bayes_pls_golite062009
G-protein coupled amine receptor activity	1.37431949258757	bayes_pls_golite062009
serotonin binding	1.33584589886834	bayes_pls_golite062009
serotonin-activated cation-selective channel activity	1.31324203158511	bayes_pls_golite062009
	1.15330735898282	bayes_pls_golite062009
channel regulator activity	1.13923307634251	bayes_pls_golite062009
toxin binding	0.91098263903324	bayes_pls_golite062009
drug binding	0.64715018605883	bayes_pls_golite062009
beta-amyloid binding	0.62979601863874	bayes_pls_golite062009
protein binding	0.406954670483187	bayes_pls_golite062009
serotonin receptor activity	0.0879353619248899	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..359]	PSI-BLAST	65.0	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
2	View Details	[360..550]	PSI-BLAST	28.39794	Acetylcholine receptor protein, gamma chain

Protein Overview: gab-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: