Protein Overview: nas-8

General Information:
Name(s) found:	nas-8 / CE31327 [WormBase]
Description(s) found: Found 20 descriptions. SHOW ALL	WBGene00003527 locus:nas-8 Zinc metalloproteinase nas-8 status:Confirmed UniProt:Q18439 protein_id:CCD66603.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	403 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [IEA]
Biological Process:	proteolysis [IEA]
Molecular Function:	zinc ion binding [IEA] astacin activity [IEA] metallopeptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRNDLLNNK ITIFLSSLSL FVIIIPIYAA EKDLLPPSTS SETFLTDEDF LRPLNDDETF  60
   61 LTEKDFKNGE KLGEDHVPAG SILWKQVYKK GDIRGKAAWK LDPKNSESLR RNGVITGTRK 120
  121 WPNGRIPYVI SNQYNDRERA VLARSFQAYH DKTCVRFVPR TAVDNDYLYI GKIDGCYSDV 180
  181 GRAGGRQELS LDNGCLQYDT AIHELMHSVG FYHEHERWDR DEHITILWHN IDREAYDQFG 240
  241 KVDLAESSYY GQLYDYYSIM HYDSLAFSKN GFETMVAKQS EMTAVIGAAI DFSPIDILKM 300
  301 NLMYQCSDVK LPPTVVGTTD KTIVPVPAPS VTVVEDDCRD RTNLCWRWID RCKSFFFEQI 360
  361 MKEFCSLSCG YCTPKALQTA KASPPNYSNT LLTKSSTSYL QHG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..255]	PSI-BLAST	13.39794	CRYSTAL STRUCTURE OF FIBROBLAST STROMELYSIN-1: THE C-TRUNCATED HUMAN PROENZYME
2	View Details	[256..309]	PSI-BLAST	38.39794	STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
3	View Details	[310..403]	PSI-BLAST	14.39794	Mannose-binding protein associated serine protease 2, MASP2

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
binding	1.14857991858078	bayes_pls_golite062009
protein binding	0.430901196209551	bayes_pls_golite062009
signal transducer activity	0.430096231919693	bayes_pls_golite062009
molecular transducer activity	0.430096231919693	bayes_pls_golite062009
receptor binding	0.26922218944514	bayes_pls_golite062009
hydrolase activity	0.26760389419911	bayes_pls_golite062009
receptor activity	0.233571796352905	bayes_pls_golite062009
protein complex binding	0.171282539150091	bayes_pls_golite062009
peptidase activity	0.129618523753667	bayes_pls_golite062009
transmembrane receptor activity	0.0544613856966465	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
receptor binding	2.52744864351239	bayes_pls_golite062009
ErbB-3 class receptor binding	2.14752073450101	bayes_pls_golite062009
binding	2.14092582858845	bayes_pls_golite062009
protein binding	1.87564165872234	bayes_pls_golite062009
ErbB-2 class receptor binding	1.86357079348628	bayes_pls_golite062009
growth factor activity	0.683947903955495	bayes_pls_golite062009
signal transducer activity	0.673391983395207	bayes_pls_golite062009
molecular transducer activity	0.673391983395207	bayes_pls_golite062009
transcription factor binding	0.5559753867952	bayes_pls_golite062009
epidermal growth factor receptor binding	0.49319143757878	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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