Protein Overview: cul-3

General Information:
Name(s) found:	cul-3 / CE27593 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000838 locus:cul-3 Cullin-3 status:Confirmed UniProt:Q17391 protein_id:CCD74336.1 [WormBase] gi\|32172452\|sp\|Q17391.2\|CUL3_CAEEL RecName: Full=Cullin-3; Short=CUL-3 [NCBI NR] gi\|17566422\|ref\|NP_503151.1\| CULlin family member (cul-3) [Caenorhabditis elegans] [NCBI NR] gi\|14670190\|gb\|AAK72067.1\|AC024744_1 Cullin protein 3 [Caenorhabditis elegans] [NCBI NR] Cullin-3 OS=Caenorhabditis elegans GN=cul-3 PE=1 SV=2 [Swiss-Prot] [wormpep67.fasta] CE27593 WBGene00000838 locus:cul-3 status:Confirmed SW:Q17391 protein_id:AAK72067.1 [wormpep150.fasta] 27593 WBGene00000838 locus:cul-3 status:Confirmed SW:Q17391 protein_id:AAK72067.1 [wormpep130-phg-ecoli-orf-rand.fasta] cullin (90.2 kD) (cul-3) [Caenorhabditis elegans]gi\|14670190\|gb\|AAK72067.1\| Cullin protein 3 [Caenorhabditis elegans]gi\|32172452\|sp\|Q17391\|CUL3_CAEEL Cullin 3 [nrdb_11152004_Chlamydomonas] locus:cul-3 status:Confirmed SW:Q17391 protein_id:AAK72067.1 [wormpep115.fasta.reversed] CE27593 status:Confirmed TR:Q95Y32 protein_id:AAK72067.1 [wormpep80.hongbin] CE27593 WBGene00000838 locus:cul-3 status:Confirmed UniProt:Q17391 protein_id:AAK72067.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE27593 WBGene00000838 locus:cul-3 status:Confirmed UniProt:Q17391 protein_id:AAK72067.1\| [wormORF-contam.fasta] Cullin protein 3 [Caenorhabditis elegans] [nr-271106-contam.fasta] CULlin family member (cul-3) [Caenorhabditis elegans] [nr-271106-contam.fasta] Cullin-3 [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE27593 WBGene00000838 locus:cul-3 status:Confirmed UniProt:Q17391 protein_id:CCD74336.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE27593 WBGene00000838 locus:cul-3 status:Confirmed UniProt:Q17391 protein_id:CCD74336.1 Cullin-3 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	777 amino acids
Gene Ontology:
Cellular Component:	cullin-RING ubiquitin ligase complex [IEA]
Biological Process:	pronuclear migration [IMP] embryonic development ending in birth or egg hatching [IMP ] cell cycle [IEA]
Molecular Function:	ubiquitin protein ligase binding [IEA] protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGRSGNGGQ QKMRIRPFMA TIDEQYVTQT WELLKRAIQE IQRKNNSGLS FEELYRNAYT  60
   61 MVLHKHGERL YNGLKDVIQD HMASVRIRII ESMNSGSFLE TVAESWADHT VAMVMIRDIL 120
  121 MYMDRIYVAQ NNHVLPVYNL GLDAYRTEIL RQNGIGDRIR DALLELIKLD RKSNQINWHG 180
  181 IKNACDMLIS LGIDSRTVYE DEFERPLLKE TSDYYRDVCK NWLSGDNDAC FYLAQVEIAM 240
  241 HDEASRASRY LDKMTEAKIL QVMDDVMVAE HIQTIVYMQN GGVKFMLEHK KIEDLTRIFR 300
  301 IFKRIGDSVT VPGGGLKALL KAVSEYLNET GSNIVKNEDL LKNPVNFVNE LLQLKDYFSS 360
  361 LLTTAFADDR DFKNRFQHDF ETFLNSNRQS PEFVALYMDD MLRSGLKCVS DAEMDNKLDN 420
  421 VMILFRYLQE KDVFEKYFKQ YLAKRLLLDK SCSDDVEKAL LAKLKTECGC QFTQKLENMF 480
  481 RDKELWLTLA TSFRDWREAQ PTKMSIDISL RVLTAGVWPT VQCNPVVLPQ ELSVAYEMFT 540
  541 QYYTEKHTGR KLTINTLLGN ADVKATFYPP PKASMSNEEN GPGPSSSGES MKERKPEHKI 600
  601 LQVNTHQMII LLQFNHHNRI SCQQLMDELK IPERELKRNL QSLALGKASQ RILVRKNKGK 660
  661 DAIDMSDEFA VNDNFQSKLT RVKVQMVTGK VESEPEIRET RQKVEDDRKL EVEAAIVRIM 720
  721 KARKKLNHNN LVAEVTQQLR HRFMPSPIII KQRIETLIER EYLARDEHDH RAYQYIA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
ubiquitin-protein ligase activity	9.47178230940453	bayes_pls_golite062009
small conjugating protein ligase activity	9.15192834197166	bayes_pls_golite062009
acid-amino acid ligase activity	8.12051073361876	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	6.87003086224111	bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity	6.55844152294696	bayes_pls_golite062009
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
transcription repressor activity	3.85678231380989	bayes_pls_golite062009
ligase activity	3.66453881539688	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
binding	2.3219000606044	bayes_pls_golite062009
nucleic acid binding	2.21939548334548	bayes_pls_golite062009
protein binding	2.20237620151495	bayes_pls_golite062009
DNA binding	2.06132216820898	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.70025468248325	bayes_pls_golite062009
structure-specific DNA binding	1.33374581364046	bayes_pls_golite062009
specific transcriptional repressor activity	0.96257232341735	bayes_pls_golite062009
transporter activity	0.891050405674973	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
DNA replication origin binding	0.71823621709622	bayes_pls_golite062009
DNA-dependent ATPase activity	0.697234220778482	bayes_pls_golite062009
transmembrane transporter activity	0.648150681919233	bayes_pls_golite062009
substrate-specific transporter activity	0.368917395770011	bayes_pls_golite062009
transcription corepressor activity	0.322180400748724	bayes_pls_golite062009
DNA helicase activity	0.300899564141452	bayes_pls_golite062009
double-stranded DNA binding	0.286130392009263	bayes_pls_golite062009
structural molecule activity	0.272316540117209	bayes_pls_golite062009
sequence-specific DNA binding	0.257777071965243	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.249771970501337	bayes_pls_golite062009
catalytic activity	0.201606344181603	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.175575779922515	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.107671044044222	bayes_pls_golite062009
structural constituent of ribosome	0.0912115683429473	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.0856082199488197	bayes_pls_golite062009
transferase activity	0.064832527337659	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..777]	PSI-BLAST	1000.0	No description for 2hyeC was found.

Protein Overview: cul-3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: