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Protein Overview: dpy-31

General Information:
Name(s) found: dpy-31 / CE27200 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00006592 locus:dpy-31 Zinc metalloproteinase dpy-31 status:Confirmed UniProt:P98060 protein_id:CCD70758.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKIFIIFGL LSLCAAHSLR DLSNKDEEDP PSSAPGVRKR RMMSEEDQKT VDYYMDKLNK  60
   61 LADEKHPEEI ERHKNPELVA WDRKRDSVLN PEEQGKFFQG DIVLYPEQAK ALYEQALTEG 120
  121 KTRVKRKFIG SNLRRWDASR PIIYAFDGSH TQREQRIIEL ALEHWHNITC LNFQRNDQAN 180
  181 SGNRIVFTDV DGCASNVGRH PLGEEQLVSL APECIRLGVI AHEVAHALGF WHEQSRPDRD 240
  241 QYVTVRWENI DKDSKGQFLK EDPDDVDNAG VPYDYGSIMH YRSKAFSKFD DLYTISTYVT 300
  301 DYQKTIGQRD QLSFNDIRLM NKIYCSAVCP SKLPCQRGGY TDPRRCDRCR CPDGFTGQYC 360
  361 EQVMPGYGAT CGGKISLTRS TTRISSPGYP REFKEGQECS WLLVAPPGHI VEFQFIGEFE 420
  421 MYCKIRHSLC MDYVEVRNST DFANTGMRYC CYGTPPTRIR SATTDMVVLF RSFYRGGKGF 480
  481 EARARAVPEA GNWNSWSPWT ACSATCGACG SRMRTRTCPP GNACSGEPVE TQICNTQACT 540
  541 GMCAQKREEE GQCGGFLSLL RGVRCRQEKT VMAPCENACC PGFTLQRGRC VR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] deduced N/A No confident structure predictions are available.
    2 View Details [88..298] PSI-BLAST 34.221849 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [299..592] PSI-BLAST 18.522879 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  4.1917763812737 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.85190688399485 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.22757426039234 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.98133341931091 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78513171530601 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  2.54952091441017 bayes_pls_golite062009
  • binding
    		•  0.910292205820092 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • integrin binding
    		•  0.65764952681937 bayes_pls_golite062009
  • protein binding
    		•  0.553658909577001 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.492456025063956 bayes_pls_golite062009
  • receptor activity
    		•  0.332822250208465 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.136560284009247 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.00533877867882504 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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