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Protein Overview: lin-2

General Information:
Name(s) found: lin-2 / CE27132 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00002991 locus:lin-2 Protein lin-2 status:Partially_confirmed UniProt:P54936 protein_id:CAA90759.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 620 amino acids

    Gene Ontology:
    Cellular Component: cell junction [IDALink to PubMed article]
    Biological Process: positive regulation of vulval development [IMPLink to PubMed article]
    post-embryonic development [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSAATPPPM EHTSSEDSTT APLQTPSSSS CLDVTVAVGT SVSYLKASPL VSSPTSLVVD  60
   61 ITESSSTLLY DKIKALPCEP VVTEVDTSTL RKETLNQIDG LLGPSPEALE LRQLLNSPHL 120
  121 ASCVQALDVV VCEIRDPKNE ASGSGDKEGN CVSSDPAPAY LNGGVLPLGA QRAGTSFEHF 180
  181 NQSAVHTSYD EEEEELYDCM SRLRLVQFQK DTQEPMGITL KVNEDGRCFV ARIMHGGMIH 240
  241 RQATLHVGDE IREINGMSVA NRSVESLQEM LRDARGQVTF KIIPSYRSAP PACEIFVRAQ 300
  301 FDYEPSQDDL IPCPQAGIPF KTGDILQVIS KDDHNWWQAR FVSSFPSIGN SSNAQRSNQQ 360
  361 QVAGLIPSPE LQEWRTACLA MERSKNTCNT HCMWFNKKKK YYTTKYLQKH SALFDQLDLV 420
  421 TYEEVMRLSQ YRRKTLVLLG AHGVGRRHIK NTLIHRHPNR FAYPIPHTTR PPRKDEVDGK 480
  481 HYYFVTNEQM MADIQNNEYL EYGTHEESMY GTKLETIRNI HKSGKIAILD VEPQALKVLR 540
  541 TAEYSPFVVF IAAPNLQGMQ DPDGSLEKLL NESDVLRQAF GHLFDFIITN SDIDDTIAQL 600
  601 ERLVEKLPAY PQWLPVTWVY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..194] Pfam 14.568636 No description for PF02828.7 was found. No confident structure predictions are available.
    3 View Details [195..292] PSI-BLAST 17.69897 Cask/Lin-2
    4 View Details [293..414] FFAS03 3.88 beta3 subunit complexed with aid
    5 View Details [415..620] PSI-BLAST 37.0 Guanylate kinase-like domain of Cask

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.2595117613307 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  3.03529700765506 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.83180079733297 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.39826531242265 bayes_pls_golite062009
  • protein binding
    		•  2.35875654816667 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.22344653950083 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  1.79696347300128 bayes_pls_golite062009
  • guanylate kinase activity
    		•  1.70730560221787 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  1.69528181005421 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51162321843898 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51162321843898 bayes_pls_golite062009
  • PDZ domain binding
    		•  1.4161955255054 bayes_pls_golite062009
  • actin binding
    		•  0.734175820477621 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.64214865642772 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.387065538161985 bayes_pls_golite062009
  • receptor binding
    		•  0.359972518335054 bayes_pls_golite062009
  • structural molecule activity
    		•  0.339803285888713 bayes_pls_golite062009
    4
    Term Confidence Notes
  • binding
    		•  2.96288334076272 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.90420281193896 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.82087628734305 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.51719769231912 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.42590326752843 bayes_pls_golite062009
  • protein binding
    		•  1.92580716027275 bayes_pls_golite062009
  • signal transducer activity
    		•  1.78618922267834 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.78618922267834 bayes_pls_golite062009
  • actin binding
    		•  1.78444456344995 bayes_pls_golite062009
  • actin filament binding
    		•  0.697156220996695 bayes_pls_golite062009
  • structural molecule activity
    		•  0.367876817922396 bayes_pls_golite062009
    5
    Term Confidence Notes
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  4.94368959158184 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.00431985024242 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.98749135039029 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.88411242531695 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  3.66392587433723 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4124368949006 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.212476179089 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.0687919953843 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.01973954110645 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  2.24094813695083 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  1.96697952975573 bayes_pls_golite062009
  • motor activity
    		•  1.55763083999583 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.08697924060619 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.03255157977314 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • guanylate kinase activity
    		•  0.98934362137863 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.84931691607013 bayes_pls_golite062009
  • DNA binding
    		•  0.702147676354075 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.489050800152752 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.485303203507997 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.482413717607895 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.457886666766291 bayes_pls_golite062009
  • adenylate kinase activity
    		•  0.447752711852745 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.442941451960958 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.440672169804309 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.440612929099368 bayes_pls_golite062009
  • nucleotide binding
    		•  0.433111366205869 bayes_pls_golite062009
  • receptor activity
    		•  0.381142123108547 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.355770151889237 bayes_pls_golite062009
  • actin binding
    		•  0.351722091343607 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  0.20818362273204 bayes_pls_golite062009
  • GTPase activity
    		•  0.20128275658561 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  0.0871526397126998 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle