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Protein Overview: hch-1

General Information:
Name(s) found: hch-1 / CE24964 [WormBase]
Description(s) found:
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  • WBGene00001828 locus:hch-1 Zinc metalloproteinase nas-34 status:Confirmed UniProt:Q21059 protein_id:CAB61002.1 [WormBase]
  • pir||S71630 metalloproteinase (EC 3.4.24.-) hch-1 precursor - Caenorhabditis elegans [NCBI NR]
  • gi|6435513|emb|CAB61002.1| C. elegans protein F40E10.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|57012923|sp|Q21059.1|NAS34_CAEEL RecName: Full=Zinc metalloproteinase nas-34; AltName: Full=Nematode astacin 34; AltName: Full=Defective hatching protein 1; Flags: Precursor [NCBI NR]
  • gi|17568533|ref|NP_510440.1| defective HatCHing family member (hch-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|1374685|dbj|BAA12861.1| HCH-1 [Caenorhabditis elegans] [NCBI NR]
  • Zinc metalloproteinase nas-34 OS=Caenorhabditis elegans GN=hch-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE24964 WBGene00001828 locus:hch-1 metalloprotease status:Confirmed SW:Q21059 protein_id:CAB61002.1 [wormpep150.fasta]
  • 24964 WBGene00001828 locus:hch-1 metalloprotease status:Confirmed TR:Q21059 protein_id:CAB61002.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • defective HatCHing HCH-1, hatching and cell migration factor, Zinc protease of the tolloid / BMP-1 family (66.2 kD) (hch-1) [Caenorhabditis elegans]gi|6435513|emb|CAB61002.1| Hypothetical protein F40E10.1 [Caenorhabditis elegans]gi|7511487|pir||S71630 m [nrdb_11152004_Chlamydomonas]
  • CE24964 WBGene00001828 locus:hch-1 metalloprotease status:Confirmed TR:Q21059 protein_id:CAB61002.1 [wormpep132.fasta]
  • 24964 WBGene00001828 locus:hch-1 metalloprotease status:Confirmed SW:Q21059 protein_id:CAB61002.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:hch-1 metalloprotease status:Confirmed TR:Q21059 protein_id:CAB61002.1 [wormpep115.fasta.reversed]
  • CE24964 locus:hch-1 metalloprotease status:Confirmed TR:Q21059 protein_id:CAB61002.1 [wormpep80.hongbin]
  • CE24964 WBGene00001828 locus:hch-1 metalloprotease status:Confirmed UniProt:Q21059 protein_id:CAB61002.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE24964 WBGene00001828 locus:hch-1 metalloprotease status:Confirmed UniProt:Q21059 protein_id:CAB61002.1| [wormORF-contam.fasta]
  • F40E10.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Zinc metalloproteinase nas-34 precursor (Nematode astacin 34) (Defective hatching protein 1) [nr-271106-contam.fasta]
  • Hypothetical protein F40E10.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • HCH-1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE24964 WBGene00001828 locus:hch-1 status:Confirmed UniProt:Q21059 protein_id:CAB61002.1 Zinc metalloproteinase nas-34 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 605 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSYWPVLIV LCLLPICHAK SYFADFVNGK GPFKQADALK FMDKMTILNK LQADILGIPQ  60
   61 PDEFSALDFE DKIESKPDEI PYLFEGDMVL TDEQMDLIIK NVRDQYWARK SSTNEFLYAI 120
  121 RGKRSMTSFL SERWSFPVPY YIDTSSGVNT NAVLAGVAKW EQETCARFTR LNSYSSSSRQ 180
  181 NALRFISGNG CYSNIGKVSR FPQDVSIGWG CTSLGTVCHE IGHALGFYHE QARYDRDDYV 240
  241 SILTQNIQDM YLSQFTKQSA SSMVDYGVGY DYGSVMHYDQ AAFSSTGGNT IATRDPNFQA 300
  301 TIGQRVAPSF ADVKRINFAY CNSTCSNYLD CQNGGYINPN DCNNCKCPPG FGGQLCDVAG 360
  361 TNSNGCGAGD ITATSSIQTI SASGALTCNY VIKAPVGAKV YFQMTAATFS RYSPCTTNYL 420
  421 EINYGRDFSR VGARFCASYP TISLSETNTL VVIYKGVNGA RFSLNYRYDP VTFSTSAPTT 480
  481 TSTTTTTAPI TVPTVSPTTT TTRQTTTTAR TSTTTTTTQA PPTTTTSTSQ CASWSACSAQ 540
  541 CGGCGTQSRR CGTYVETVYC NTNPCTGGYC CRPFFYVTSF GTGYCRRPGA DTPAAPQRYV 600
  601 EQRKG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] deduced N/A No confident structure predictions are available.
    2 View Details [72..263] PSI-BLAST 40.0 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [264..605] PSI-BLAST 5.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  4.1917763812737 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.85190688399485 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.22757426039234 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.98133341931091 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78513171530601 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  2.54952091441017 bayes_pls_golite062009
  • transporter activity
    		•  1.28982382930122 bayes_pls_golite062009
  • binding
    		•  1.19918194301835 bayes_pls_golite062009
  • integrin binding
    		•  1.14306661858478 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.0688261398267 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.798767221679673 bayes_pls_golite062009
  • protein binding
    		•  0.553658909577001 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.543737159152136 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.492456025063956 bayes_pls_golite062009
  • receptor activity
    		•  0.332822250208465 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.241890854867053 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.136560284009247 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.00533877867882504 bayes_pls_golite062009
    3
    Term Confidence Notes
  • ErbB-2 class receptor binding
    		•  2.43291483229075 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.40375706430672 bayes_pls_golite062009
  • receptor binding
    		•  2.19335005546698 bayes_pls_golite062009
  • binding
    		•  2.19152785302602 bayes_pls_golite062009
  • protein binding
    		•  1.99839937208979 bayes_pls_golite062009
  • transcription factor binding
    		•  0.89765738417424 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.82506902766668 bayes_pls_golite062009
  • growth factor activity
    		•  0.473340802107115 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.225989825753998 bayes_pls_golite062009
  • pattern binding
    		•  0.0196006376432096 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle