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Protein Overview: dkf-1

General Information:
Name(s) found: dkf-1 / CE20167 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00012352 locus:dkf-1 Serine\/threonine-protein kinase dkf-1 status:Partially_confirmed UniProt:Q9XUJ7 protein_id:CAB04940.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 722 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGSQGSTDY GDHVVLRYGG TREMVPLIRH EQMLDMLMER ARQIVQGFGN LDTRNMYLFR  60
   61 HEYNSPTLLY PITSASQITS GSILEIILVD RTEAAVIPHV VEPESYMRPT FCDFCGEMLT 120
  121 GLMRQGVKCK NCNGNFHKRC SNAARNNCGA PGAPGAQPSR PPILPPIPTT PTGFPVAALS 180
  181 TPTGLPHTLI EHSYRQFTVC KVCDHLLVGL VKQGLKCRDC GVNVHRKCAM ELASNCVLSE 240
  241 NAISRVNFTD PEGPGSSSSD NIPLFRLPGQ VGTRATEKKK LEGWMMHFIL SDPERRLKHY 300
  301 WMMQSNAIHL YNEYSEGIGV NPNRVYRIIP LAEITSVVQN NGKSVLAKHP PHCFEIRTTT 360
  361 NTVFCVGEDY HAFSGGPPKK IPRSMSVRPS SNTTMWFQFI KESLQPPSRN EDNAEQALEF 420
  421 ANLYQVLSDK TLGSGQFGTV YSAIQRHSGK EVAVKVISKE RFSKKGSGAE SMRAEVAILQ 480
  481 QTCHPGIVCL EFMCETKDKI FVVMEKMNGD MLEMILSQEL GRLNSRATKF LLVQILCALK 540
  541 YLHDQGIAHC DLKPENVLLS DMGSNFPQTK ICDFGYARFI PESQFRKTVV GTPAYLPPEV 600
  601 LQRKGYNKSL DMWSVGVIIY VTLSGTFPFN EGEEISEQIQ NASFMFPTEP WSEVEPLAVD 660
  661 LIQKLLKVEI EARMSIEQCL DHGWLKGEQL YRDLRDLEVR LNTPRYLTSP QDDILYGTLV 720
  721 NP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] PSI-BLAST 11.522879 THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
    2 View Details [81..241] PSI-BLAST 15.522879 Crystal Structure of the Human Beta2-Chimaerin
    3 View Details [242..411] FFAS03 3.04 Solution structure of the PH domain of protein kinase C, D2 type from human
    4 View Details [412..722] PSI-BLAST 64.30103 No description for 2cn5A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.35732272412639 bayes_pls_golite062009
  • tubulin binding
    		•  2.17448062213288 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.10724980780815 bayes_pls_golite062009
  • microtubule binding
    		•  1.93078273560396 bayes_pls_golite062009
  • protein binding
    		•  1.86841453215444 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.63853240069891 bayes_pls_golite062009
  • kinase activity
    		•  1.62384132584197 bayes_pls_golite062009
  • protein kinase activity
    		•  1.5956463895254 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.51475136357956 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.50825759862682 bayes_pls_golite062009
  • signal transducer activity
    		•  1.50825759862682 bayes_pls_golite062009
  • transferase activity
    		•  1.25776281736571 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.673589832597734 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.599634454232833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.576819726104993 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.562594294957137 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.546422207034767 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.525788464472489 bayes_pls_golite062009
  • DNA binding
    		•  0.422142077605877 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.334601927012824 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.315664702789604 bayes_pls_golite062009
  • receptor binding
    		•  0.298046142314417 bayes_pls_golite062009
  • enzyme binding
    		•  0.240262781026149 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.162163146322721 bayes_pls_golite062009
  • protein tag
    		•  0.00311613478935058 bayes_pls_golite062009
    2
    Term Confidence Notes
  • diacylglycerol kinase activity
    		•  2.62274004397594 bayes_pls_golite062009
  • binding
    		•  2.36195429973813 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.12546774457691 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.80739081420522 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.70650638346167 bayes_pls_golite062009
  • signal transducer activity
    		•  1.70650638346167 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.39167263636091 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.37139209958305 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.19392095748004 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.911061212692491 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.907368864863833 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.746688776397071 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.661240850692236 bayes_pls_golite062009
  • DNA binding
    		•  0.618071969351071 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0701429188109299 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.73312450062269 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.35640415776708 bayes_pls_golite062009
  • actin binding
    		•  2.15139219039706 bayes_pls_golite062009
  • signal transducer activity
    		•  1.97025592796299 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.97025592796299 bayes_pls_golite062009
  • protein binding
    		•  1.95763087285706 bayes_pls_golite062009
  • receptor activity
    		•  1.7532159500599 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.72393003840462 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.71957805451003 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.55414958698765 bayes_pls_golite062009
  • protein kinase activity
    		•  1.53914015577029 bayes_pls_golite062009
  • kinase activity
    		•  1.52393509273639 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.39413069155432 bayes_pls_golite062009
  • transporter activity
    		•  1.29925758003665 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.24159469960645 bayes_pls_golite062009
  • receptor binding
    		•  1.17585427851367 bayes_pls_golite062009
  • transferase activity
    		•  1.09391396934652 bayes_pls_golite062009
  • enzyme binding
    		•  0.986198119454688 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.902696448574164 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.830314446783898 bayes_pls_golite062009
  • kinase binding
    		•  0.829679711601002 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.807688160227952 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.77769334991472 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.650240628628722 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.62326150960884 bayes_pls_golite062009
  • protein kinase binding
    		•  0.557283580441975 bayes_pls_golite062009
  • actin filament binding
    		•  0.516969879010319 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.462744818503729 bayes_pls_golite062009
  • protein complex binding
    		•  0.424439033593144 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.42289557002454 bayes_pls_golite062009
  • DNA binding
    		•  0.362931880290478 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.358136502761366 bayes_pls_golite062009
  • structural molecule activity
    		•  0.332112521019418 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.191468082618045 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.183587483764957 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.174772802535455 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0687306550834211 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0123738509852108 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0042696817373139 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.00109440156897189 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle