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Protein Overview: tax-2

General Information:
Name(s) found: tax-2 / CE17780 [WormBase]
Description(s) found:
Found 32 descriptions.
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  • WBGene00006525 locus:tax-2 status:Confirmed UniProt:G5EEE2 protein_id:CAB04328.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 800 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    cAMP-dependent protein kinase complex [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    neuron projection morphogenesis [IMPLink to PubMed article]
    regulation of neuron differentiation [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ion channel activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    cAMP-dependent protein kinase regulator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQVPKRAKT NLAREIRKRE FSYVDRQKAS KPTQLSEKEW KSPRSEDSFD LLDPANASKE  60
   61 PSASTRPLPY PPTRPPEVVI QIDEVESPIL GLIDETDDHE LDGRLDPASS FDANSLSATR 120
  121 ASSIIEDDVR SQISFIMRER LHSIAKEVHR RTSAVREDLI RETPEDTVSM ASNVPKQNEH 180
  181 RPSLMSLIGL QNRSESPTVD TVKNCFGFSL KGTFHPYGRF YMTWLSLVTL CFLFNAFCIP 240
  241 LRSSYPYQTA DNWMYWFIVD YSCDLVYVID MLLIKPRLRF TRGGIQVKIY KDTQRHYLMT 300
  301 RTFKLDILSI LPTDLMYFFF GKMPIWRINR VLKINSFWLL FDMLDNSFAN PYAIRIARTL 360
  361 SYMIYIIHCN SCVYYKLSAL QAFGQIAYLE NGKWYLNKWV YNNQGNAYIR CFYFTAAVAT 420
  421 STGNNPAPTN VIEYIYMTCS WMMGVFVFAL LLGQIRDIVS NANRNREEFQ RKMDLALGEC 480
  481 KKLGLKMETT NRVRDWFIYT WQQQKTLDEK KLIEKLPLKL QTDLALSVHY TTLSKVQLFQ 540
  541 DCDRALLRDL VLKLRPVIFL PGDMICLKGD VGKEMYIINQ GILQVVGGDH NEKIFAELAQ 600
  601 GAVFGEISLL AIGGNNRRTA SIRAKGYCTL FVLAKEDLND VIRYYPQAQT ILRRKAAAML 660
  661 KNDKKSDEKT EKIKAQAELE DRCKINPRQV PKLITLIANM TEMNENKGVQ ELKKVIEEET 720
  721 EKSRRQSIYY PWSTLQRDDD DEEEWNDEED LSDVGEDFDL DPTNHSDDED PMEDVDLAPE 780
  781 VHDDDWDQPG TSGTQKLHAD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..484] PSI-BLAST 25.522879 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [485..674] PSI-BLAST 23.39794 HCN2J 443-645 in the presence of cGMP
    3 View Details [675..800] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • ion channel activity
    		•  8.54258173089828 bayes_pls_golite062009
  • gated channel activity
    		•  8.40583491856766 bayes_pls_golite062009
  • channel activity
    		•  8.39905773163311 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  8.39905773163311 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  8.39470084162975 bayes_pls_golite062009
  • cation channel activity
    		•  8.37340171056317 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.27305202954784 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.92543918512794 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.90247452112447 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  3.17407714154852 bayes_pls_golite062009
  • potassium channel activity
    		•  3.16645830461177 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.45301353888223 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.42821009576643 bayes_pls_golite062009
  • protein binding
    		•  1.86347494944834 bayes_pls_golite062009
  • binding
    		•  1.59096092728475 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.52941414851886 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33862527414723 bayes_pls_golite062009
  • DNA binding
    		•  1.17942022803543 bayes_pls_golite062009
  • signal transducer activity
    		•  0.900388370232708 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.900388370232708 bayes_pls_golite062009
  • transcription factor activity
    		•  0.720377542376114 bayes_pls_golite062009
  • transcription activator activity
    		•  0.659469524274627 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.477325600303481 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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