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View Structure Prediction Details

Protein: tax-2
Organism: Caenorhabditis elegans
Length: 800 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tax-2.

Description E-value Query
Range
Subject
Range
gi|25143142, gi|... - ref|NP_492427.2| abnormal ThermoTaXis TAX-2, cyclic nucleotide-gated channel (92.4 kD) (tax-2) [Caen...
415.0 [0..1] [800..1]

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Predicted Domain #1
Region A:
Residues: [1-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQVPKRAKT NLAREIRKRE FSYVDRQKAS KPTQLSEKEW KSPRSEDSFD LLDPANASKE  60
   61 PSASTRPLPY PPTRPPEVVI QIDEVESPIL GLIDETDDHE LDGRLDPASS FDANSLSATR 120
  121 ASSIIEDDVR SQISFIMRER LHSIAKEVHR RTSAVREDLI RETPEDTVSM ASNVPKQNEH 180
  181 RPSLMSLIGL QNRSESPTVD TVKNCFGFSL KGTFHPYGRF YMTWLSLVTL CFLFNAFCIP 240
  241 LRSSYPYQTA DNWMYWFIVD YSCDLVYVID MLLIKPRLRF TRGGIQVKIY KDTQRHYLMT 300
  301 RTFKLDILSI LPTDLMYFFF GKMPIWRINR VLKINSFWLL FDMLDNSFAN PYAIRIARTL 360
  361 SYMIYIIHCN SCVYYKLSAL QAFGQIAYLE NGKWYLNKWV YNNQGNAYIR CFYFTAAVAT 420
  421 STGNNPAPTN VIEYIYMTCS WMMGVFVFAL LLGQIRDIVS NANRNREEFQ RKMDLALGEC 480
  481 KKLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.522879
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [485-674]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKMETTNRVR DWFIYTWQQQ KTLDEKKLIE KLPLKLQTDL ALSVHYTTLS KVQLFQDCDR  60
   61 ALLRDLVLKL RPVIFLPGDM ICLKGDVGKE MYIINQGILQ VVGGDHNEKI FAELAQGAVF 120
  121 GEISLLAIGG NNRRTASIRA KGYCTLFVLA KEDLNDVIRY YPQAQTILRR KAAAMLKNDK 180
  181 KSDEKTEKIK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.39794
Match: 1q3eA
Description: HCN2J 443-645 in the presence of cGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic nucleotide-gated ion channel activity 10.1422916734545 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 10.1422916734545 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 9.72053268940283 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
ion channel activity 8.54258173089828 bayes_pls_golite062009
gated channel activity 8.40583491856766 bayes_pls_golite062009
channel activity 8.39905773163311 bayes_pls_golite062009
passive transmembrane transporter activity 8.39905773163311 bayes_pls_golite062009
substrate-specific channel activity 8.39470084162975 bayes_pls_golite062009
cation channel activity 8.37340171056317 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
ligand-gated ion channel activity 7.41584542512987 bayes_pls_golite062009
ligand-gated channel activity 7.41584542512987 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
metal ion transmembrane transporter activity 7.27305202954784 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
voltage-gated ion channel activity 4.92543918512794 bayes_pls_golite062009
voltage-gated channel activity 4.90247452112447 bayes_pls_golite062009
intracellular cAMP activated cation channel activity 3.95109938608832 bayes_pls_golite062009
voltage-gated cation channel activity 3.17407714154852 bayes_pls_golite062009
potassium channel activity 3.16645830461177 bayes_pls_golite062009
cation transmembrane transporter activity 2.45301353888223 bayes_pls_golite062009
voltage-gated potassium channel activity 2.42821009576643 bayes_pls_golite062009
protein binding 1.86347494944834 bayes_pls_golite062009
binding 1.59096092728475 bayes_pls_golite062009
transcription regulator activity 1.52941414851886 bayes_pls_golite062009
nucleic acid binding 1.33862527414723 bayes_pls_golite062009
DNA binding 1.17942022803543 bayes_pls_golite062009
signal transducer activity 0.900388370232708 bayes_pls_golite062009
molecular transducer activity 0.900388370232708 bayes_pls_golite062009
transcription factor activity 0.720377542376114 bayes_pls_golite062009
transcription activator activity 0.659469524274627 bayes_pls_golite062009
enzyme regulator activity 0.477325600303481 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [675-800]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQAELEDRCK INPRQVPKLI TLIANMTEMN ENKGVQELKK VIEEETEKSR RQSIYYPWST  60
   61 LQRDDDDEEE WNDEEDLSDV GEDFDLDPTN HSDDEDPMED VDLAPEVHDD DWDQPGTSGT 120
  121 QKLHAD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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