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Protein Overview: CE17558

General Information:
Name(s) found: CE17558 [WormBase]
Description(s) found:
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  • WBGene00008117 locus:gsr-1 status:Confirmed UniProt:Q93379 protein_id:CAB03763.1 [WormBase]
  • pir||T19972 glutathione-disulfide reductase (EC 1.8.1.7) C46F11.2 [similarity] - Caenorhabditis elegans [NCBI NR]
  • gi|71983419|ref|NP_001021220.1| hypothetical protein C46F11.2 [Caenorhabditis elegans] [NCBI NR]
  • gi|3874994|emb|CAB03763.1| C. elegans protein C46F11.2a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_497740.1| glutathione reductase (51.5 kD) (3E741) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE17558 WBGene00008117 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed TR:Q93379 protein_id:CAB03763.1 [wormpep150.fasta]
  • 17558 WBGene00008117 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed TR:Q93379 protein_id:CAB03763.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • glutathione reductase (51.5 kD) (3E741) [Caenorhabditis elegans]gi|3874994|emb|CAB03763.1| Hypothetical protein C46F11.2a [Caenorhabditis elegans]gi|7497499|pir||T19972 glutathione-disulfide reductase (EC 1.8.1.7) C46F11.2 [similarity] - Caenorhabditis [nrdb_11152004_Chlamydomonas]
  • pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed TR:Q93379 protein_id:CAB03763.1 [wormpep115.fasta.reversed]
  • CE17558 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed TR:Q93379 protein_id:CAB03763.1 [wormpep80.hongbin]
  • CE17558 WBGene00008117 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed UniProt:Q93379_CAEEL protein_id:CAB03763.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE17558 WBGene00008117 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed UniProt:Q93379_CAEEL protein_id:CAB03763.1| [wormORF-contam.fasta]
  • C46F11.2a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein C46F11.2a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE17558 WBGene00008117 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed UniProt:Q93379 protein_id:CAB03763.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE17558 WBGene00008117 locus:gsr-1 pyridine nucleotide-disulphide oxidoreductases class-I status:Confirmed UniProt:Q93379 protein_id:CAB03763.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE17558 WBGene00008117 locus:gsr-1 status:Confirmed UniProt:Q93379 protein_id:CAB03763.1 [wormpep246-ecoli-contam.fasta]
  • Glutathione diSulfide Reductase OS=Caenorhabditis elegans GN=gsr-1 PE=1 SV=2 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    removal of superoxide radicals [IEALink to PubMed article]
    glutathione metabolic process [IEALink to PubMed article]
    cell redox homeostasis [IEALink to PubMed article]
    detoxification of mercury ion [IEALink to PubMed article]
    Molecular Function: disulfide oxidoreductase activity [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    FAD binding [IEALink to PubMed article]
    mercury ion binding [IEALink to PubMed article]
    mercury (II) reductase activity [IEALink to PubMed article]
    thioredoxin-disulfide reductase activity [IEALink to PubMed article]
    glutathione-disulfide reductase activity [IEALink to PubMed article]
    dihydrolipoyl dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFRCILST SRSIMSGVKE FDYLVIGGGS GGIASARRAR EFGVSVGLIE SGRLGGTCVN  60
   61 VGCVPKKVMY NCSLHAEFIR DHADYGFDVT LNKFDWKVIK KSRDEYIKRL NGLYESGLKG 120
  121 SSVEYIRGRA TFAEDGTVEV NGAKYRGKNT LIAVGGKPTI PNIKGAEHGI DSDGFFDLED 180
  181 LPSRTVVVGA GYIAVEIAGV LANLGSDTHL LIRYDKVLRT FDKMLSDELT ADMDEETNPL 240
  241 HLHKNTQVTE VIKGDDGLLT IKTTTGVIEK VQTLIWAIGR DPLTKELNLE RVGVKTDKSG 300
  301 HIIVDEYQNT SAPGILSVGD DTGKFLLTPV AIAAGRRLSH RLFNGETDNK LTYENIATVV 360
  361 FSHPLIGTVG LTEAEAVEKY GKDEVTLYKS RFNPMLFAVT KHKEKAAMKL VCVGKDEKVV 420
  421 GVHVFGVGSD EMLQGFAVAV TMGATKKQFD QTVAIHPTSA EELVTMRGGV KPE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..473] PSI-BLAST 100.0 HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  8.42473605174108 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  8.07008457237017 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  7.86778387378753 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  7.84550673347799 bayes_pls_golite062009
  • lipoamide binding
    		•  7.21320397413054 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  6.68894387221662 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.56425883527182 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  6.2758493127081 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  6.2758493127081 bayes_pls_golite062009
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
    		•  5.32373368820399 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  4.48151296542899 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.19923051777224 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.05603184984386 bayes_pls_golite062009
  • antioxidant activity
    		•  3.99666840824738 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.78622758776028 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.68406278988218 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.50748163367583 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  3.23754178295825 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
    		•  3.15456908604913 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  3.04300775355641 bayes_pls_golite062009
  • glutathione binding
    		•  2.84679371365652 bayes_pls_golite062009
  • glutathione-disulfide reductase activity
    		•  2.72350669229836 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions
    		•  2.49798084628282 bayes_pls_golite062009
  • tubulin binding
    		•  2.40546880499445 bayes_pls_golite062009
  • catalytic activity
    		•  2.35839632763616 bayes_pls_golite062009
  • microtubule binding
    		•  2.30064869971937 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.23446140524739 bayes_pls_golite062009
  • peptide disulfide oxidoreductase activity
    		•  2.13269617402519 bayes_pls_golite062009
  • glutathione disulfide oxidoreductase activity
    		•  2.13269617402519 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.87417564758524 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  1.71836807554864 bayes_pls_golite062009
  • binding
    		•  1.50672625307126 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.42994468012845 bayes_pls_golite062009
  • protein binding
    		•  1.21627488765992 bayes_pls_golite062009
  • transporter activity
    		•  1.16027171869703 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.04563737396213 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.992020263296138 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.886337714694097 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.795364404071999 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.718226588475577 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • transferase activity
    		•  0.649374189439191 bayes_pls_golite062009
  • electron carrier activity
    		•  0.511623955786613 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
  • coenzyme binding
    		•  0.10945648874523 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle