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Protein Overview: tra-3

General Information:
Name(s) found: tra-3 / CE16260 [WormBase]
Description(s) found:
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  • WBGene00006606 locus:tra-3 Calpain-5 status:Confirmed UniProt:Q22036 protein_id:CAB05248.1 [WormBase]
  • pir||S71885 sex-determining protein transformer-3 - Caenorhabditis elegans [NCBI NR]
  • gi|595493|gb|AAB60256.1| sex determination [Caenorhabditis elegans] [NCBI NR]
  • gi|54035686|sp|Q22036.1|CAN5_CAEEL RecName: Full=Calpain-5; AltName: Full=Sex-determining transformer protein 3 [NCBI NR]
  • gi|3878546|emb|CAB05248.1| C. elegans protein LLC1.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17542636|ref|NP_502751.1| TRAnsformer : XX animals transformed into males family member (tra-3) [Caenorhabditis elegans] [NCBI NR]
  • Calpain-5 OS=Caenorhabditis elegans GN=tra-3 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Partially_confirmed SW:Q22036 protein_id:CAB05248.1 [wormpep150.fasta]
  • 16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Partially_confirmed TR:Q22036 protein_id:CAB05248.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • TRAnsformer : XX animals transformed into males TRA-3, CaLPain family member (73.6 kD) (tra-3) [Caenorhabditis elegans]gi|3878546|emb|CAB05248.1| Hypothetical protein LLC1.1 [Caenorhabditis elegans]gi|595493|gb|AAB60256.1| TRA-3gi|7451287|pir||S71885 s [nrdb_11152004_Chlamydomonas]
  • CE16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Partially_confirmed TR:Q22036 protein_id:CAB05248.1 [wormpep132.fasta]
  • 16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Partially_confirmed SW:Q22036 protein_id:CAB05248.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:tra-3 calpain (TRA-3) status:Partially_confirmed TR:Q22036 protein_id:CAB05248.1 [wormpep115.fasta.reversed]
  • CE16260 locus:tra-3 calpain (TRA-3) status:Partially_confirmed TR:Q22036 protein_id:CAB05248.1 [wormpep80.hongbin]
  • CE16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Partially_confirmed UniProt:Q22036 protein_id:CAB05248.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Partially_confirmed UniProt:Q22036 protein_id:CAB05248.1| [wormORF-contam.fasta]
  • TRAnsformer : XX animals transformed into males family member (tra-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Calpain-5 (Sex-determining transformer protein 3) [nr-271106-contam.fasta]
  • Hypothetical protein LLC1.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • sex determination [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE16260 WBGene00006606 locus:tra-3 calpain (TRA-3) status:Confirmed UniProt:Q22036 protein_id:CAB05248.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE16260 WBGene00006606 locus:tra-3 status:Confirmed UniProt:Q22036 protein_id:CAB05248.1 Calpain-5 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 648 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    membrane protein intracellular domain proteolysis [IDALink to PubMed article]
    proteolysis [IEALink to PubMed article][ISSLink to PubMed article]
    protein autoprocessing [IDALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IDALink to PubMed article][IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRSEKTRHF GNQNYEKLRK ICIKKKQPFV DTLFPPTNQS LFLEQRQSSD IVWKRPGELH  60
   61 PDPHLFVEGA SPNDVTQGIL GNCWFVSACS ALTHNFKLLA QVIPDADDQE WSTKHAYAGI 120
  121 FRFRFWRFGK WVEVVIDDLL PTRDGKLLFA RSKTPNEFWS ALLEKAFAKL YGCYENLVGG 180
  181 HLSDALQDVS GGVAETLHVR KFLKDDPNDT ELKLFNDLKT AFDKGALVVA AIAARTKEEI 240
  241 EESLDCGLVK GHAYAVSAVC TIDVTNPNER SFTSFIMGSK RKQNLIRLQN PWGEKEWNGA 300
  301 WSDDSPEWQN VSASQLSTMG VQPANSDSDD GDFWMPWESF VHYFTDISLC QLFNTSVFSF 360
  361 SRSYDEQIVF SEWTTNGKKS GAPDDRAGGC HNFKATFCNN PQYIFDIPSP NCSVMFALIQ 420
  421 NDPSEGLKKR EPFVTIGMHV MKVENNRQYR VHTAMHPIAI SDYASGRSVY LHLQSLPRGR 480
  481 YLLIPTTFAP KEQTLFMLRV YSDEHIHFSP LTKHAPKLGL LKCKSAQSVT RLTIHGVDFN 540
  541 SASTGTHNVY AILKDSRKSF RTKTLSGVKS IQWDEQFLFH KSKNRQQYKI EVWEDRKMAR 600
  601 DHLLAQSVII ALIDNENRDT TLQLTDPRGT VIGTVSVTVS AFDDPMYL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..648] PSI-BLAST 148.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.19059336788201 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.93596559605971 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.91734319991078 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43328552376748 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • protein binding
    		•  1.92445772322782 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.30577051923353 bayes_pls_golite062009
  • transporter activity
    		•  1.21845572420504 bayes_pls_golite062009
  • actin binding
    		•  1.1967948958876 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19670958990587 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11706264292297 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11706264292297 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00091316610003 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • motor activity
    		•  0.68020805045422 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.515693296786409 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.484449686814032 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.354062437867002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • DNA binding
    		•  0.306964954191276 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.246369226539662 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.193338880082314 bayes_pls_golite062009
  • tubulin binding
    		•  0.11107511867058 bayes_pls_golite062009
  • protein complex binding
    		•  0.0676093357928913 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle