Protein Overview: cul-6

General Information:
Name(s) found:	cul-6 / CE11928 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000841 locus:cul-6 Cullin-6 status:Partially_confirmed UniProt:Q21346 protein_id:CAB01230.1 [WormBase] pir\|\|T23474 hypothetical protein K08E7.7 - Caenorhabditis elegans [NCBI NR] gi\|3878416\|emb\|CAB01230.1\| C. elegans protein K08E7.7, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|2493905\|sp\|Q21346.1\|CUL6_CAEEL RecName: Full=Cullin-6 [NCBI NR] gi\|17539492\|ref\|NP_502412.1\| CULlin family member (cul-6) [Caenorhabditis elegans] [NCBI NR] Cullin-6 OS=Caenorhabditis elegans GN=cul-6 PE=1 SV=1 [Swiss-Prot] [wormpep67.fasta] CE11928 WBGene00000841 locus:cul-6 LIN-19 like protein status:Partially_confirmed SW:Q21346 protein_id:CAB01230.1 [wormpep150.fasta] 11928 WBGene00000841 locus:cul-6 LIN-19 like protein status:Partially_confirmed SW:Q21346 protein_id:CAB01230.1 [wormpep130-phg-ecoli-orf-rand.fasta] cullin (cul-6) [Caenorhabditis elegans]gi\|3878416\|emb\|CAB01230.1\| Hypothetical protein K08E7.7 [Caenorhabditis elegans]gi\|7505557\|pir\|\|T23474 hypothetical protein K08E7.7 - Caenorhabditis elegansgi\|2493905\|sp\|Q21346\|CUL6_CAEEL Cullin 6 [nrdb_11152004_Chlamydomonas] locus:cul-6 LIN-19 like protein status:Partially_confirmed SW:Q21346 protein_id:CAB01230.1 [wormpep115.fasta.reversed] CE11928 locus:cul-6 LIN-19 like protein status:Partially_confirmed SW:Q21346 protein_id:CAB01230.1 [wormpep80.hongbin] CE11928 WBGene00000841 locus:cul-6 LIN-19 like protein status:Partially_confirmed UniProt:Q21346 protein_id:CAB01230.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE11928 WBGene00000841 locus:cul-6 LIN-19 like protein status:Partially_confirmed UniProt:Q21346 protein_id:CAB01230.1\| [wormORF-contam.fasta] Hypothetical protein K08E7.7 [Caenorhabditis elegans] [nr-271106-contam.fasta] Cullin-6 [nr-271106-contam.fasta] CULlin family member (cul-6) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE11928 WBGene00000841 locus:cul-6 status:Partially_confirmed UniProt:Q21346 protein_id:CAB01230.1 Cullin-6 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	729 amino acids
Gene Ontology:
Cellular Component:	cullin-RING ubiquitin ligase complex [IEA]
Biological Process:	DNA repair [IMP] positive regulation of growth rate [IMP] embryonic development ending in birth or egg hatching [IMP] cell cycle [IEA]
Molecular Function:	ubiquitin protein ligase binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIEAVWGTL QDGLNLLYRR EHMSKKYYMM LYDAVYNICT TTTLANSNNN SPEFASEFLY  60
   61 KQLENYIRTY VIAIRDRISA CSGDELLGKC TIEWDNFKFS TRICNCIFQY LNRNFVSKKV 120
  121 EDKNGEIVEI YKLALDIWKA EFFDNFKVKT IDAILELILL ERCGSTINST HISSVVECLT 180
  181 ELDIYKVSFE PQFLDATKLF YKQEVLNSKE TVIEYMITVE NRLFQEEYRS RRYLGPSTND 240
  241 LLIDSCESIL ISDRLKFLHS EFERLLEARK DEHLTRMYSL CRRVTHGLED LRVYLEKRIL 300
  301 KEGHETLQRL AKDSGLKTTP KEYITKLLEV HEIYFNLINK AFDRNALFMQ SLDKASKDFI 360
  361 EANAVTMLAP EKHRSTRSAD YLARYCDQLL KKNSKVQDET ALDKALTVLK YISEKDVFQL 420
  421 YYQNWFSERI INNSSASDDA EEKFITNLTA TEGLEYTRNL VKMVEDAKIS KDLTTEFKDI 480
  481 KTEKSIDFNV ILQTTGAWPS LDQIKIILPR ELSTILKEFD TFYNASHNGR RLNWAYSQCR 540
  541 GEVNSKAFEK KYVFIVTASQ LCTLYLFNEQ DSFTIEQISK AIEMTAKSTS AIVGSLNPVI 600
  601 DPVLVVDKGN EKDGYPPDAV VSLNTKYANK KVRVDLTTAI KKATADRETD AVQNTVESDR 660
  661 KYEIKACIVR IMKTRKSLTH TLLINEIISQ LKSRFTPNVQ MIKICIEILI EQLYIRRSEN 720
  721 EHNVYEYLA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
ubiquitin-protein ligase activity	9.95820721075934	bayes_pls_golite062009
small conjugating protein ligase activity	9.63704265478699	bayes_pls_golite062009
acid-amino acid ligase activity	8.59660059921406	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	7.32718329074249	bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity	6.69190468636718	bayes_pls_golite062009
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
ligase activity	4.08678005991666	bayes_pls_golite062009
transcription repressor activity	3.85678231380989	bayes_pls_golite062009
binding	2.45185337633142	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
protein binding	2.34145982999922	bayes_pls_golite062009
nucleic acid binding	2.21939548334548	bayes_pls_golite062009
DNA binding	2.06132216820898	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.70025468248325	bayes_pls_golite062009
structure-specific DNA binding	1.33374581364046	bayes_pls_golite062009
specific transcriptional repressor activity	0.96257232341735	bayes_pls_golite062009
transporter activity	0.891050405674973	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
DNA replication origin binding	0.71823621709622	bayes_pls_golite062009
DNA-dependent ATPase activity	0.697234220778482	bayes_pls_golite062009
transmembrane transporter activity	0.648150681919233	bayes_pls_golite062009
substrate-specific transporter activity	0.368917395770011	bayes_pls_golite062009
catalytic activity	0.351553138703956	bayes_pls_golite062009
transcription corepressor activity	0.322180400748724	bayes_pls_golite062009
DNA helicase activity	0.300899564141452	bayes_pls_golite062009
double-stranded DNA binding	0.286130392009263	bayes_pls_golite062009
structural molecule activity	0.272316540117209	bayes_pls_golite062009
sequence-specific DNA binding	0.257777071965243	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.249771970501337	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.175575779922515	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.107671044044222	bayes_pls_golite062009
structural constituent of ribosome	0.0912115683429473	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.0856082199488197	bayes_pls_golite062009
transferase activity	0.064832527337659	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..729]	PSI-BLAST	1000.0	Crystal Structure of The Cand1-Cul1-Roc1 Complex

Protein Overview: cul-6

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: