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Protein Overview: cul-6

General Information:
Name(s) found: cul-6 / CE11928 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00000841 locus:cul-6 Cullin-6 status:Partially_confirmed UniProt:Q21346 protein_id:CAB01230.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 729 amino acids

    Gene Ontology:
    Cellular Component: cullin-RING ubiquitin ligase complex [IEALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    cell cycle [IEALink to PubMed article]
    Molecular Function: ubiquitin protein ligase binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIEAVWGTL QDGLNLLYRR EHMSKKYYMM LYDAVYNICT TTTLANSNNN SPEFASEFLY  60
   61 KQLENYIRTY VIAIRDRISA CSGDELLGKC TIEWDNFKFS TRICNCIFQY LNRNFVSKKV 120
  121 EDKNGEIVEI YKLALDIWKA EFFDNFKVKT IDAILELILL ERCGSTINST HISSVVECLT 180
  181 ELDIYKVSFE PQFLDATKLF YKQEVLNSKE TVIEYMITVE NRLFQEEYRS RRYLGPSTND 240
  241 LLIDSCESIL ISDRLKFLHS EFERLLEARK DEHLTRMYSL CRRVTHGLED LRVYLEKRIL 300
  301 KEGHETLQRL AKDSGLKTTP KEYITKLLEV HEIYFNLINK AFDRNALFMQ SLDKASKDFI 360
  361 EANAVTMLAP EKHRSTRSAD YLARYCDQLL KKNSKVQDET ALDKALTVLK YISEKDVFQL 420
  421 YYQNWFSERI INNSSASDDA EEKFITNLTA TEGLEYTRNL VKMVEDAKIS KDLTTEFKDI 480
  481 KTEKSIDFNV ILQTTGAWPS LDQIKIILPR ELSTILKEFD TFYNASHNGR RLNWAYSQCR 540
  541 GEVNSKAFEK KYVFIVTASQ LCTLYLFNEQ DSFTIEQISK AIEMTAKSTS AIVGSLNPVI 600
  601 DPVLVVDKGN EKDGYPPDAV VSLNTKYANK KVRVDLTTAI KKATADRETD AVQNTVESDR 660
  661 KYEIKACIVR IMKTRKSLTH TLLINEIISQ LKSRFTPNVQ MIKICIEILI EQLYIRRSEN 720
  721 EHNVYEYLA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..729] PSI-BLAST 1000.0 Crystal Structure of The Cand1-Cul1-Roc1 Complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.95820721075934 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.63704265478699 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.59660059921406 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.32718329074249 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  6.69190468636718 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • ligase activity
    		•  4.08678005991666 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • binding
    		•  2.45185337633142 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21939548334548 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.70025468248325 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.33374581364046 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • DNA replication origin binding
    		•  0.71823621709622 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.697234220778482 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • catalytic activity
    		•  0.351553138703956 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.300899564141452 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.286130392009263 bayes_pls_golite062009
  • structural molecule activity
    		•  0.272316540117209 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.257777071965243 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.175575779922515 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0912115683429473 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.0856082199488197 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle