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Protein Overview: alh-11

General Information:
Name(s) found: alh-11 / CE07233 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000117 locus:alh-11 status:Confirmed UniProt:Q20352 protein_id:CCD61886.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 687 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    Biological Process: cellular aldehyde metabolic process [IEALink to PubMed article]
    proline metabolic process [IEALink to PubMed article]
    negative regulation of transcription [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    10-formyltetrahydrofolate catabolic process [IEALink to PubMed article]
    proline biosynthetic process [IEALink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    betaine biosynthetic process [IEALink to PubMed article]
    one-carbon metabolic process [IEALink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    betaine-aldehyde dehydrogenase activity [IEALink to PubMed article]
    proline dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    aldehyde dehydrogenase [NAD(P)+] activity [IEALink to PubMed article]
    methylmalonate-semialdehyde dehydrogenase (acylating) activity [IEALink to PubMed article]
    glutamate-5-semialdehyde dehydrogenase activity [IEALink to PubMed article]
    formyltetrahydrofolate dehydrogenase activity [IEALink to PubMed article]
    transcription repressor activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKPGDVVFY SRGTESTDFC DAVEKVVPDN TYYHVAIVSE RGTIVEATGD GVLEYSLQKS  60
   61 IEENRPGCLE ILEVANCCEK VLEAAATWSW TKLGLPYNDL FAADLINSDG KESYYCSQLI 120
  121 TAAFEFAGVD MKWPAHTLNF NDKNVNQISF WNEYFEKRGK SQVPQGEEGS HPAQLRRSPR 180
  181 LLLKMRIFPN LINLNSLTET KLLELSSHFV AGNHVEFPSD RKFEVIEPRS GKPMATWHYA 240
  241 TRDQVDLTVK EAKKAQKQWA KSSWMERSEI LKKTGDLLKT HCNDIAYWEC ISNGKPIAEA 300
  301 KADVLSCVDT FYFYSGIASD LLGQHVPLDA SRYAYTRRLP VGVVAAIGAW NYPIQTCSWK 360
  361 TAPALACGNA VIYKPSPLSP VTALILAEIL KSAGLPDGVF NVIQGDAETA QDLIHHDGVS 420
  421 KVSFTGSIPT GKKIMKACAD RNIKPVTLEL GGKSALIVFD DADIDSAVSC AMMANFYSQG 480
  481 QVCSNASKVL VHKSVLKEFT KKLVDHTQKM KIGDPLKEDT QVGSHISAEH RNKVEGYIST 540
  541 AIAEGATKLC GGDRVAVHGL ENGFYLSPCI LTGITPKMTV YREEIFGSVL LIIPFDTEDE 600
  601 AIKIANDTDM GLAAGLVTKD LSRSYRVSEQ LNAGNVYVNT YNDVSPLVPF GGVGESGFGR 660
  661 ENGTAVLEHY THLKSVFVNT GTCPNPF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 39.522879 Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with acetate
    2 View Details [205..687] PSI-BLAST 155.0 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  4.35175408702761 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  4.2273960318884 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  3.27180265380824 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.99564252244797 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  2.70230501280821 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • acyl-CoA binding
    		•  2.26220696569489 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  1.6559690223037 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • binding
    		•  1.06673666884196 bayes_pls_golite062009
  • protein binding
    		•  0.894945263794726 bayes_pls_golite062009
  • retinoid binding
    		•  0.801468424891608 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.719034630339067 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.258030369394064 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle