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View Structure Prediction Details

Protein: alh-11
Organism: Caenorhabditis elegans
Length: 687 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for alh-11.

Description E-value Query
Range
Subject
Range
gi|157776880 - gi|157776880|ref|XP_001666506.1| hypothetical protein CBG15207 [Caenorhabditis briggsae AF16]
gi|39586099, gi|... - gi|39586099|emb|CAE69175.1| Hypothetical protein CBG15207 [Caenorhabditis briggsae], gi|187027331|em...
776.0 [0..1] [687..1]

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Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKPGDVVFY SRGTESTDFC DAVEKVVPDN TYYHVAIVSE RGTIVEATGD GVLEYSLQKS  60
   61 IEENRPGCLE ILEVANCCEK VLEAAATWSW TKLGLPYNDL FAADLINSDG KESYYCSQLI 120
  121 TAAFEFAGVD MKWPAHTLNF NDKNVNQISF WNEYFEKRGK SQVPQGEEGS HPAQLRRSPR 180
  181 LLLKMRIFPN LINLNSLTET KLLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.522879
Match: 1tj2A
Description: Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with acetate
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [205-687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSSHFVAGNH VEFPSDRKFE VIEPRSGKPM ATWHYATRDQ VDLTVKEAKK AQKQWAKSSW  60
   61 MERSEILKKT GDLLKTHCND IAYWECISNG KPIAEAKADV LSCVDTFYFY SGIASDLLGQ 120
  121 HVPLDASRYA YTRRLPVGVV AAIGAWNYPI QTCSWKTAPA LACGNAVIYK PSPLSPVTAL 180
  181 ILAEILKSAG LPDGVFNVIQ GDAETAQDLI HHDGVSKVSF TGSIPTGKKI MKACADRNIK 240
  241 PVTLELGGKS ALIVFDDADI DSAVSCAMMA NFYSQGQVCS NASKVLVHKS VLKEFTKKLV 300
  301 DHTQKMKIGD PLKEDTQVGS HISAEHRNKV EGYISTAIAE GATKLCGGDR VAVHGLENGF 360
  361 YLSPCILTGI TPKMTVYREE IFGSVLLIIP FDTEDEAIKI ANDTDMGLAA GLVTKDLSRS 420
  421 YRVSEQLNAG NVYVNTYNDV SPLVPFGGVG ESGFGRENGT AVLEHYTHLK SVFVNTGTCP 480
  481 NPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 155.0
Match: 1a4sA
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.09598561374689 bayes_pls_golite062009
oxidoreductase activity 4.47226217021998 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 4.35175408702761 bayes_pls_golite062009
malonate-semialdehyde dehydrogenase (acetylating) activity 4.2273960318884 bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity 3.87605237828483 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity 3.64672165191647 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 3.37049090049734 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2867555127991 bayes_pls_golite062009
glutamate-5-semialdehyde dehydrogenase activity 3.27180265380824 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.99564252244797 bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity 2.81851373615334 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity 2.71501590413507 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 2.70230501280821 bayes_pls_golite062009
aldehyde dehydrogenase [NAD(P)+] activity 2.43250909158896 bayes_pls_golite062009
aminobutyraldehyde dehydrogenase activity 2.35958138496479 bayes_pls_golite062009
acyl-CoA binding 2.26220696569489 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.6559690223037 bayes_pls_golite062009
retinal dehydrogenase activity 1.42867174920845 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
protein binding 0.894945263794726 bayes_pls_golite062009
retinoid binding 0.801468424891608 bayes_pls_golite062009
isoprenoid binding 0.719034630339067 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009
benzaldehyde dehydrogenase (NAD+) activity 0.23487570676521 bayes_pls_golite062009

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