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Protein Overview: CE06504

General Information:
Name(s) found: CE06504 [WormBase]
Description(s) found:
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  • WBGene00012011 status:Partially_confirmed UniProt:Q22766 protein_id:CAA94373.1 [WormBase]
  • pir||T25258 hypothetical protein T25B9.5 - Caenorhabditis elegans [NCBI NR]
  • gi|3880181|emb|CAA94373.1| C. elegans protein T25B9.5, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17542550|ref|NP_501993.1| hypothetical protein T25B9.5 [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE06504 WBGene00012011 Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Predicted TR:Q22766 protein_id:CAA94373.1 [wormpep150.fasta]
  • 06504 WBGene00012011 Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Predicted TR:Q22766 protein_id:CAA94373.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • tyrosine kinase family member (4L518) [Caenorhabditis elegans]gi|3880181|emb|CAA94373.1| Hypothetical protein T25B9.5 [Caenorhabditis elegans]gi|7508424|pir||T25258 hypothetical protein T25B9.5 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Predicted TR:Q22766 protein_id:CAA94373.1 [wormpep115.fasta.reversed]
  • CE06504 Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Predicted TR:Q22766 protein_id:CAA94373.1 [wormpep80.hongbin]
  • CE06504 WBGene00012011 Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Predicted UniProt:Q22766_CAEEL protein_id:CAA94373.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE06504 WBGene00012011 Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Predicted UniProt:Q22766_CAEEL protein_id:CAA94373.1| [wormORF-contam.fasta]
  • Hypothetical protein T25B9.5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • T25B9.5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE06504 WBGene00012011 Src homology domain 2, protein tyrosine kinase (ABL subfamily) status:Partially_confirmed UniProt:Q22766 protein_id:CAA94373.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE06504 WBGene00012011 status:Partially_confirmed UniProt:Q22766 protein_id:CAA94373.1 [wormpep246-ecoli-contam.fasta]
  • CE06504 WBGene00012011 status:Partially_confirmed UniProt:Q22766 protein_id:CAA94373.1 Non-specific protein-tyrosine kinase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
  • Isoform of A0A061ADQ6, Tyrosine-protein kinase OS=Caenorhabditis elegans GN=CELE_T25B9.5 PE=3 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 541 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSVISSSDF KRNFKIPMAS SDIEASDKNP NEAGADKLES GNKNVSTSMM SNSSSDPEED  60
   61 YIRSHLINLH VYHGVLFGSE AEKLLTWDRA YLVRRAITKP NKFLCISVNW KKKIFHYQLD 120
  121 FNEDGWCCKK LYEKFPTMPN RRFLHIRQLL EAWPQATPFL IPTPRGSNVL IHSTINLDKK 180
  181 LGCGAFGEVF KGQYKAVGST NPPIEVAVKR ILGNAKRKQI QEFCNEAQIM TVLQHENIVA 240
  241 FYGFASLEEP IMVVMELVTG GDLRKYLQTT QNIPKLQILW FAMNVASGMR HLSSKGIIHR 300
  301 DLAARNCLVT QDLKAKISDF GLSLQGTEVT TKNLEKAPIR WLAPESLKSG MFNEKTDVWS 360
  361 YGVFLTELMA RCEHDPLYPK SLKDAKAWIL TEERPHKMEN GDPKELMVLI DACCERNPNE 420
  421 RLNFNTVKRQ ITDIYMEALN KGPQDGRKPE NSAMTVLTSK TSEDRTRISL NRKKSVDRQK 480
  481 IPSSSKRSFF SSLRKKNKDQ VTLPAGMSIS PSTNSAKPPS SETPNTGSSS PNAPTPPPQA 540
  541 K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..445] PSI-BLAST 100.0 No description for 2h8hA was found.
    2 View Details [446..541] PSI-BLAST 51.69897 No description for 2acxA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.91037901281763 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.349343975617553 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle