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Protein Overview: hcp-3

General Information:
Name(s) found: hcp-3 / CE00219 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00001831 locus:hcp-3 Histone H3-like centromeric protein hcp-3 status:Confirmed UniProt:P34470 protein_id:CAA80160.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 288 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    condensed chromosome, centromeric region [IDALink to PubMed article]
    nucleosome [IEALink to PubMed article]
    Biological Process: mitotic spindle organization [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    kinetochore assembly [IMPLink to PubMed article]
    nucleosome assembly [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDTPIIEE IAEQNESVTR IMQRLKHDMQ RVTSVPGFNT SAAGVNDLID ILNQYKKELE  60
   61 DDAANDYTEA HIHKIRLVTG KRNQYVLKLK QAEDEYHARK EQARRRASSM DFTVGRNSTN 120
  121 LVDYSHGRHH MPSYRRHDSS DEENYSMDGT NGDGNRAGPS NPDRGNRTGP SSSDRVRMRA 180
  181 GRNRVTKTRR YRPGQKALEE IRKYQKTEDL LIQKAPFARL VREIMQTSTP FGADCRIRSD 240
  241 AISALQEAAE AFLVEMFEGS SLISTHAKRV TLMTTDIQLY RRLCLRHL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] deduced N/A No confident structure predictions are available.
    2 View Details [147..288] PSI-BLAST 52.0 Crystal structure of the nucleosome core particle containing the histone domain of macroH2A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  4.57339366278729 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • centromeric DNA binding
    		•  2.60445660474495 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38228606466152 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.3574713307436 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.30859203490073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • protein binding
    		•  1.07873333188144 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  0.725138319268162 bayes_pls_golite062009
  • histone binding
    		•  0.218942897869955 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0885263144317296 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0852726470007639 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle