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View Structure Prediction Details

Protein: hcp-3
Organism: Caenorhabditis elegans
Length: 288 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hcp-3.

Description E-value Query
Range
Subject
Range
cpar-1 - Histone H3 similarity status:Partially_confirmed UniProt:P34440 protein_id:CAA80154.1
281.0 [0..1] [288..1]
gi|157774451 - gi|157774451|ref|XP_001665291.1| hypothetical protein CBG10032 [Caenorhabditis briggsae AF16]
HCP3L_CAEBR - Histone H3-like centromeric protein cpar-1 OS=Caenorhabditis briggsae GN=cpar-1 PE=3 SV=1
251.0 [0..3] [288..5]
gi|88943485 - gi|88943485|ref|XP_497711.2| PREDICTED: similar to H3 histone, family 2 isoform 2 [Homo sapiens]
220.0 [0..155] [287..44]
gi|109508757, gi... - gi|109508757|ref|XP_001075226.1| PREDICTED: similar to H3 histone, family 3B [Rattus norvegicus], gi...
217.0 [0..151] [287..12]
gi|50728592 - gi|50728592|ref|XP_416193.1| PREDICTED: similar to histone protein Hist2h3c1 [Gallus gallus]
217.0 [0..146] [287..611]
gi|76612880 - gi|76612880|ref|XP_871849.1| PREDICTED: similar to H3 histone, family 2 isoform 2 [Bos taurus]
215.0 [0..148] [287..199]
gi|77548740, gi|... - gi|77548740|gb|ABA91537.1| histone H3 [Oryza sativa (japonica cultivar-group)], gi|62701879|gb|AAX92...
211.0 [0..156] [287..1]
gi|74004208 - gi|74004208|ref|XP_545397.2| PREDICTED: similar to histone 1, H2ai (predicted) [Canis familiaris]
211.0 [0..156] [287..17]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDTPIIEE IAEQNESVTR IMQRLKHDMQ RVTSVPGFNT SAAGVNDLID ILNQYKKELE  60
   61 DDAANDYTEA HIHKIRLVTG KRNQYVLKLK QAEDEYHARK EQARRRASSM DFTVGRNSTN 120
  121 LVDYSHGRHH MPSYRRHDSS DEENYS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [147-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGTNGDGNR AGPSNPDRGN RTGPSSSDRV RMRAGRNRVT KTRRYRPGQK ALEEIRKYQK  60
   61 TEDLLIQKAP FARLVREIMQ TSTPFGADCR IRSDAISALQ EAAEAFLVEM FEGSSLISTH 120
  121 AKRVTLMTTD IQLYRRLCLR HL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.0
Match: 1u35A
Description: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 4.57339366278729 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
centromeric DNA binding 2.60445660474495 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38228606466152 bayes_pls_golite062009
transcription repressor activity 2.3574713307436 bayes_pls_golite062009
transcription corepressor activity 1.30859203490073 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription initiation factor activity 0.725138319268162 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009
transcription coactivator activity 0.0885263144317296 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle