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View Structure Prediction Details

Protein: hcp-3
Organism: Caenorhabditis elegans
Length: 288 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hcp-3.

Description E-value Query
Range
Subject
Range
cpar-1 - Histone H3 similarity status:Partially_confirmed UniProt:P34440 protein_id:CAA80154.1
281.0 [0..1] [288..1]
gi|157774451 - gi|157774451|ref|XP_001665291.1| hypothetical protein CBG10032 [Caenorhabditis briggsae AF16]
HCP3L_CAEBR - Histone H3-like centromeric protein cpar-1 OS=Caenorhabditis briggsae GN=cpar-1 PE=3 SV=1
251.0 [0..3] [288..5]
gi|88943485 - gi|88943485|ref|XP_497711.2| PREDICTED: similar to H3 histone, family 2 isoform 2 [Homo sapiens]
220.0 [0..155] [287..44]
gi|109508757, gi... - gi|109508757|ref|XP_001075226.1| PREDICTED: similar to H3 histone, family 3B [Rattus norvegicus], gi...
217.0 [0..151] [287..12]
gi|50728592 - gi|50728592|ref|XP_416193.1| PREDICTED: similar to histone protein Hist2h3c1 [Gallus gallus]
217.0 [0..146] [287..611]
gi|76612880 - gi|76612880|ref|XP_871849.1| PREDICTED: similar to H3 histone, family 2 isoform 2 [Bos taurus]
215.0 [0..148] [287..199]
gi|77548740, gi|... - gi|77548740|gb|ABA91537.1| histone H3 [Oryza sativa (japonica cultivar-group)], gi|62701879|gb|AAX92...
211.0 [0..156] [287..1]
gi|74004208 - gi|74004208|ref|XP_545397.2| PREDICTED: similar to histone 1, H2ai (predicted) [Canis familiaris]
211.0 [0..156] [287..17]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDTPIIEE IAEQNESVTR IMQRLKHDMQ RVTSVPGFNT SAAGVNDLID ILNQYKKELE  60
   61 DDAANDYTEA HIHKIRLVTG KRNQYVLKLK QAEDEYHARK EQARRRASSM DFTVGRNSTN 120
  121 LVDYSHGRHH MPSYRRHDSS DEENYS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [147-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGTNGDGNR AGPSNPDRGN RTGPSSSDRV RMRAGRNRVT KTRRYRPGQK ALEEIRKYQK  60
   61 TEDLLIQKAP FARLVREIMQ TSTPFGADCR IRSDAISALQ EAAEAFLVEM FEGSSLISTH 120
  121 AKRVTLMTTD IQLYRRLCLR HL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.0
Match: 1u35A
Description: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 4.57339366278729 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
centromeric DNA binding 2.60445660474495 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38228606466152 bayes_pls_golite062009
transcription repressor activity 2.3574713307436 bayes_pls_golite062009
transcription corepressor activity 1.30859203490073 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription initiation factor activity 0.725138319268162 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009
transcription coactivator activity 0.0885263144317296 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle