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Protein Overview: hst4

General Information:
Name(s) found: hst4 / SPAC1783.04c [Sanger Pombe]
Description(s) found:
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  • gi|6714824|emb|CAB66167.1| Sir2 family histone deacetylase Hst4 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|5833950|gb|AAD53752.1|AF173939_1 Hst4p [Schizosaccharomyces pombe] [NCBI NR]
  • gi|46396036|sp|Q9UR39.1|HST4_SCHPO RecName: Full=NAD-dependent deacetylase hst4; AltName: Full=Homologous to SIR2 protein 4 [NCBI NR]
  • gi|19114571|ref|NP_593659.1| Sir2 family histone deacetylase Hst4 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • pir||T50106 hst4p [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • Sir2 family histone deacetylase Hst4 [Sanger Pombe]
  • NAD-dependent deacetylase hst4 OS=Schizosaccharomyces pombe GN=hst4 PE=2 SV=1 [Swiss-Prot]
  • SIR2-LIKE HISTONE DEACETYLASE; INVOLVED IN CHROMATIN SILENCING; INVOLVED IN CENTROMERIC FUNCTIONS; MOST SIMILAR TO S. CEREVISIAE HST4: Q9UR39; [pompepVF.fasta]
  • SIR2 HOMOLOGUE WITH SILENCING AND CENTROMERIC FUNCTIONS: Q9UR39; [pompepV13]
  • HST4P [pompep4896]
  • |hst4||SIR2-like histone deacetylase [pompepnew.fasta]
  • NAD-dependent deacetylase hst4 (EC 3.5.1.-) (Homologous to SIR2 protein 4) [4896.FASTAC]
  • |hst4||Sir2p family|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • hst4p [Schizosaccharomyces pombe]gi|6714824|emb|CAB66167.1| SPAC1783.04c [Schizosaccharomyces pombe]gi|5833950|gb|AAD53752.1| Hst4p [Schizosaccharomyces pombe]gi|11359064|pir||T50106 hst4p [imported] - fission yeast (Schizosaccharomyces pombe)gi|46396 [nrdb_11152004_Chlamydomonas]
  • |hst4||Sir2 family histone deacetylase|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9UR39) HST4P [pompep4896_normal_reversed]
  • |hst4||Sir2 family histone deacetylase Hst4|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPAC1783.04c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Hst4p [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC1783.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • NAD-dependent deacetylase hst4 (Homologous to SIR2 protein 4) [nr-271106-contam.fasta]
  • NAD-dependent protein deacetylase hst4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hst4 PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 415 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    chromatin remodeling complex [ISSLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: DNA damage checkpoint [IMPLink to PubMed article]
    chromatin remodeling [ISSLink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    histone deacetylation [IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    regulation of nucleosome density [IEPLink to PubMed article]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [IEPLink to PubMed article]
    histone H3 deacetylation [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    transcription corepressor activity [IEPLink to PubMed article]
    transcription regulator activity [ICLink to PubMed article]
    NAD-dependent histone deacetylase activity [TASLink to PubMed article]
    specific transcriptional repressor activity [IEPLink to PubMed article]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVEEHVPLI QESRKRKCQS SENASKRQQL LSKLPLRLHT GNENVDLSPL VSAIRKAKRI  60
   61 VVVTGAGISC DAGIPDFRSS EGLFSSLRAE YKLNCSGKEL FDGSVYRDLK SVNIFHAMIR 120
  121 KLHMLSNNAR PTDFHLFLSQ LAQESKLLRL YTQNIDFLET RLEGLQTCIP LPQSAPWPTT 180
  181 IPLHGTLEVV SCTRCSFLKK FNPDIFDRNG VTVCPDCKTE NEVRRIAGKR SVIEGCLRPR 240
  241 IVLYNEIHPD SESIGSVCSQ DLKSRPDCLI VAGTSCKIPG VKRIIKEMSN CVHKQKGNVI 300
  301 WLNYDEPTKD FLNLCDLVVQ GDLQIAIRRL KPLLDAPSWK LKSHSAKRTS KQKSSEQTKI 360
  361 TSSTKITKAI GLNTKSNDSS KKDNTSFQLH QVLNSIEIPK VEIKQEVEYA TPSPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..415] PSI-BLAST 64.221849 Structure and autoregulation of the yeast Hst2 homolog of Sir2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  4.76068488405318 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  4.76068488405318 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  4.51070381823692 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  2.82468859281133 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  1.11434618720209 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.877271524804045 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  0.0099486881187274 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle