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Protein Overview: dot2

General Information:
Name(s) found: dot2 / SPBC651.05c [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • EAP30 family protein Dot2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 252 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    ESCRT II complex [ISSLink to PubMed article]
    [NOT]spindle pole body [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    extrinsic to membrane [IEA]
    Biological Process: meiotic telomere clustering [IMPLink to PubMed article]
    protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway [IMPLink to PubMed article]
    spindle pole body organization [IMPLink to PubMed article]
    late endosome to vacuole transport [IMPLink to PubMed article]
    meiosis I [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKRIGIGAL NDDEYLKQYE EVGNELIEQQ SDEIASQLST FQEALKTFAR EHATEIKQNS  60
   61 QFRNTFVKLA LKIGLDPFVS GSDESAWAAV GMNEFYYQVA VRVIEVCYAT QMENGGLLSV 120
  121 SQVCRFLNEE NEAFGHEWLR ETDVVRAVDS LAPLGPGFVL EKIAGKQYIR SLPLELNTDQ 180
  181 NVVLEAVEIL GYVTISILRD NYAWERSRCI QVLNDLVSKS LLWIDSQGVE MAYWGASNLI 240
  241 DDQAQRFLYE NF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..252] PSI-BLAST 88.30103 Structure of the ESCRT-II endosomal trafficking complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.48053910222825 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.750801486608713 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • signal transducer activity
    		•  0.574575108509588 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.574575108509588 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle