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Protein Overview: pfs2

General Information:
Name(s) found: pfs2 / SPAC12G12.14c [Sanger Pombe]
Description(s) found:
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  • pir||T37587 hypothetical trp-asp repeats containing protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|5912374|emb|CAB55873.1| WD repeat protein Pfs2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113796|ref|NP_592884.1| WD repeat protein Pfs2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|12644484|sp|Q9UTN4.1|PFS2_SCHPO RecName: Full=Polyadenylation factor subunit 2 [NCBI NR]
  • WD repeat protein Pfs2 [Sanger Pombe]
  • (Q9UTN4) Hypothetical WD-repeat protein C12G12.14c in chromosome I [Swiss-Prot]
  • Polyadenylation factor subunit 2 OS=Schizosaccharomyces pombe GN=pfs2 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE POLYADENYLATION FACTOR I SUBUNIT; MRNA 3'-END PROCESSING; WD REPEAT PROTEIN; SIMILAR TO S. CEREVISIAE PFS2: Q09876;Q9UTN4; [pompepVF.fasta]
  • WD REPEAT PROTEIN: Q09876;Q9UTN4; [pompepV13]
  • Hypothetical WD-repeat protein C12G12.14c in chromosome I [pompep4896]
  • |||putative polyadenylation factor I subunit [pompepnew.fasta]
  • |pfs2||WD repeat protein|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • hypothetical trp-asp repeats containing protein [Schizosaccharomyces pombe]gi|5912374|emb|CAB55873.1| SPAC12G12.14c [Schizosaccharomyces pombe]gi|12644484|sp|Q9UTN4|YAGE_SCHPO Hypothetical WD-repeat protein C12G12.14c in chromosome Igi|7492055|pir||T37 [nrdb_11152004_Chlamydomonas]
  • |pfs2||WD repeat protein Pfs2|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC12G12.14c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Polyadenylation factor subunit 2 [nr-271106-contam.fasta]
  • hypothetical protein SPAC12G12.14c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Polyadenylation factor subunit 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pfs2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 509 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    mRNA cleavage and polyadenylation specificity factor complex [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    [NOT]nucleolus [IDALink to PubMed article]
    Biological Process: G1/S transition of mitotic cell cycle [IMPLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    mRNA 3'-end processing [IMPLink to PubMed article]
    mRNA polyadenylation [ISSLink to PubMed article]
    mRNA cleavage [ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERAENARII QKPMTRRTVD YGSGLSKYIV NRHLRSNRYH IHVPRPNPNQ IINLYPPYEY  60
   61 KYNNTSSLCT KYIHTSANKA RHVINVVRWT PDGRRLLTGS STGEFTLWNG LTFNFELINQ 120
  121 SHDYAVRCAE WSTDGRWLIS GDGGGMVKYF EPNLNNVKIV QAHEMEVRDV AFSPNDSKFV 180
  181 TASDDGSLKV WNFHMSTEEL KLTGHGWDVK TVDWHPSKGL LASGSKDNLV KFWDPRTGTC 240
  241 IATLHGHKNT IMQASFQKNF GSNYLATVSR DSTCRVFDLR AMKDVRVLRG HEKDVNCVTW 300
  301 HPLYPNLLTT GGSDGSVNHY SLDEPPLLSQ QKYHEKHPNV TLSASSYLLY PTAEIPFAHD 360
  361 LGIWSMQYHP LGHLLCTGSN DKTTRFWSRS RPDDKESTMD RHHLGEEQSE AMLSQRKAAI 420
  421 EEDDNYEPDE NPLTETLANA HNPQFSGVLN LPGLGTMPSF PSPYQHGQPQ IPGMLHASLS 480
  481 NSYAEPSTQN SFIPGLTSKS QDGYPQNYR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] PSI-BLAST 69.39794 No description for 2gnqA was found.
    2 View Details [82..143] PSI-BLAST 24.39794 Arp2/3 complex 41 kDa subunit ARPC1
    3 View Details [144..509] PSI-BLAST 50.39794 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • actin binding
    		•  3.31804728298431 bayes_pls_golite062009
  • snoRNA binding
    		•  3.28507672512266 bayes_pls_golite062009
  • GTPase activity
    		•  3.23750443966606 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • dynactin binding
    		•  1.85146647785657 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • actin filament binding
    		•  1.5197243426595 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47097979074281 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.21305848427711 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.11754260203517 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • ligase activity
    		•  0.93058496790047 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.168317261786777 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • kinase activity
    		•  0.127621956173205 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle