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Protein Overview: shk2

General Information:
Name(s) found: shk2 / SPAC1F5.09c [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • PAK-related kinase Shk2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 589 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: MAPKKK cascade [IGILink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    regulation of conjugation with cellular fusion by signal transduction [NAS]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    protein serine/threonine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLSVRGVPV EIPSLKDTKK SKGIIRSGWV MLKEDKMKYL PWTKKWLVLS SNSLSIYKGS  60
   61 KSESAQVTLL LKDIQKVERS KSRTFCFKLR FKSSTKNFEI QACELSVADN MECYEWMDLI 120
  121 SSRALASKVS SPMNPKHQVH VGIDNEGNYV GLPKEWILLL QSSSITKQEC MEEPKAVIQA 180
  181 LDFYSKQLDT TSETKDSFSF CKETLPRSST TSYSIRDADK HHKLTTSGVT KMNITERCKP 240
  241 KTTIQTDKKH IIRPFIEDKS HVESIMTGKV TKVPVKADSK NTLSRRMTDR QALAMLKDSV 300
  301 TSHDPVEYFN VKHKLGQGAS GSVYLAKVVG GKQLGIFDSV AIKSIDLQCQ TRKELILNEI 360
  361 TVMRESIHPN IVTYLDSFLV RERHLWVVME YMNAGSLTDI IEKSKLTEAQ IARICLETCK 420
  421 GIQHLHARNI IHRDIKSDNV LLDNSGNIKI TDFGFCARLS NRTNKRVTMV GTPYWMAPEV 480
  481 VKQNEYGTKV DIWSLGIMII EMIENEPPYL REDPIRALYL IAKNGTPTLK KPNLVSKNLK 540
  541 SFLNSCLTID TIFRATAAEL LTHSFLNQAC PTEDLKSIIF SRKANTHIN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 3.69897 Fibroblast growth factor receptor, FGFR
    2 View Details [185..302] deduced N/A No confident structure predictions are available.
    3 View Details [303..589] PSI-BLAST 78.0 pak1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • telethonin binding
    		•  4.65477965121932 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.13965049450794 bayes_pls_golite062009
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • alpha-actinin binding
    		•  3.78238468811253 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.59139016029428 bayes_pls_golite062009
  • actin binding
    		•  2.2974991205682 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • tubulin binding
    		•  2.08792429244614 bayes_pls_golite062009
  • actinin binding
    		•  1.66611153821577 bayes_pls_golite062009
  • antigen binding
    		•  1.63189745559168 bayes_pls_golite062009
  • actin filament binding
    		•  1.60525682912279 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.52958974617075 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.47807703678891 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46196700012641 bayes_pls_golite062009
  • kinase activity
    		•  1.39954632432505 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • DNA binding
    		•  1.30832040941913 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.30657787244536 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30604420685085 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.24730237107473 bayes_pls_golite062009
  • growth factor binding
    		•  1.21242049144353 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.20218845204373 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.17845072849922 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.965431415167831 bayes_pls_golite062009
  • peptide antigen binding
    		•  0.90772544726282 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • transferase activity
    		•  0.756515665570446 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • transcription factor activity
    		•  0.65158151382396 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.610042878900289 bayes_pls_golite062009
  • structural molecule activity
    		•  0.567620977360967 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • IgG binding
    		•  0.39706457466099 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  0.236289246965336 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.20101044847022 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.0972287515196089 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle