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Protein Overview: rfc1

General Information:
Name(s) found: rfc1 / SPBC23E6.07c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • DNA replication factor C complex subunit Rfc1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 934 amino acids

    Gene Ontology:
    Cellular Component: Ctf18 RFC-like complex [TASLink to PubMed article]
    Elg1 RFC-like complex [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    nuclear replication fork [IC]
    nucleolus [IEA]
    DNA replication factor C complex [TASLink to PubMed article]
    Rad17 RFC-like complex [TASLink to PubMed article]
    Biological Process: DNA repair [ISSLink to PubMed article]
    DNA-dependent DNA replication [IGILink to PubMed article]
    leading strand elongation [ISSLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    DNA clamp loader activity [ICLink to PubMed article]
    protein binding [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSDIRSFF GGGNAQKKPK VSPTPTSPKP KRSLKKKRIV LSDDEDGTIE NSKVPASKSK  60
   61 VQKRNESEDI SHSLPSIVHE DDKLVGSDGV STTPDEYFEQ QSTRSRSKPR IISNKETTTS 120
  121 KDVVHPVKTE NFANDLDTTS DSKPVVHQTR ATRKPAQPKA EKSTTSKSKS HTTTATTHTS 180
  181 RSSKSKGLPR FSDEVSQALK NVPLIDVDSM GVMAPGTFYE RAATTQTPGS KPVPEGNSDC 240
  241 LSGISFVITG ILETLTRQEA TDLIKQYGGK VTGAPSVRTD FILLGENAGP RKVETIKQHK 300
  301 IPAINEDGLF YLITHLPASG GTGAAAQAAQ QKKEQEEKKI LETVARMDDS NKKESQPSQI 360
  361 WTSKYAPTSL KDICGNKGVV QKLQKWLQDY HKNRKSNFNK PGPDGLGLYK AVLLSGPPGI 420
  421 GKTTAAHLVA KLEGYDVLEL NASDTRSKRL LDEQLFGVTD SQSLAGYFGT KANPVDMAKS 480
  481 RLVLIMDEID GMSSGDRGGV GQLNMIIKKS MIPIICICND RAHPKLRPLD RTTFDLRFRR 540
  541 PDANSMRSRI MSIAYREGLK LSPQAVDQLV QGTQSDMRQI INLLSTYKLS CSEMTPQNSQ 600
  601 AVIKNSEKHI VMKPWDICSR YLHGGMFHPS SKSTINDKLE LYFNDHEFSY LMVQENYLNT 660
  661 TPDRIRQEPP KMSHLKHLEL ISSAANSFSD SDLVDSMIHG PQQHWSLMPT HALMSCVRPA 720
  721 SFVAGSGSRQ IRFTNWLGNN SKTNKLYRML REIQVHMRLK VSANKLDLRQ HYIPILYESL 780
  781 PVKLSTGHSD VVPEIIELMD EYYLNREDFD SITELVLPAD AGEKLMKTIP TAAKSAFTRK 840
  841 YNSSSHPIAF FGSSDVLPMK GSAQREVPDV EDAIEAEDEM LEEASDSEAA NEEDIDLSKD 900
  901 KFISVPKKPK KRTKAKAEAS SSSSTSRRSR KKTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..606] PSI-BLAST 20.0 N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
    2 View Details [607..700] PSI-BLAST 41.69897 Replication factor C
    3 View Details [701..850] PSI-BLAST 60.0 Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA)
    4 View Details [851..934] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  6.51495346697904 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  6.40748863504898 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.51625633651862 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
    		• 1.85506769032946 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  1.69026972999845 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  1.68890613599528 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.30090199952739 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • motor activity
    		•  1.03253378953548 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  0.629563765934841 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  0.0136229525922795 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle